2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine
- Product Name
- 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine
- CAS No.
- 179687-79-7
- Chemical Name
- 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine
- Synonyms
- Neratinib Impurity 35;2-((4-chloro-3-nitrophenoxy)methyl)pyridine;2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine;Pyridine, 2-[(2-chloro-4-nitrophenoxy)methyl]-;3-Chloro-4-(2-pyridinylmethoxy)-1-nitrobenzene
- CBNumber
- CB4855383
- Molecular Formula
- C12H9ClN2O3
- Formula Weight
- 264.66
- MOL File
- 179687-79-7.mol
2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine Property
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- Light brown to brown Powder
N-Bromosuccinimide Price
- Product number
- CS-M0296
- Product name
- 2-((2-chloro-4-nitrophenoxy)methyl)pyridine
- Packaging
- 250mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- P372
- Product name
- 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine
- Packaging
- 250mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- FC147747
- Product name
- 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine
- Packaging
- 500mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- FC147747
- Product name
- 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine
- Packaging
- 1g
- Price
- $260
- Updated
- 2021/12/16
- Product number
- FC147747
- Product name
- 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine
- Packaging
- 2g
- Price
- $340
- Updated
- 2021/12/16
2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine Chemical Properties,Usage,Production
Uses
3-Chloro-4-(2-pyridylmethyloxy)nitrobenzene was used to synthesize aniline ''headgroups'' and incorporat them into an alkynyl thienopyrimidine series of EGFR and ErbB-?2 inhibitors.
Synthesis
619-08-9
6959-47-3
179687-79-7
General procedure for the synthesis of 2-((2-chloro-4-nitrophenoxy)methyl)pyridine from 2-chloro-4-nitrophenol and 2-chloromethylpyridine hydrochloride: 2-chloromethylpyridine hydrochloride (16.4 g, 0.1 mol) and potassium carbonate (K2CO3, 27.6 g, 0.2 mol) were suspended in N,N-dimethylformamide (DMF, 100 mL). stirred for 30 min at room temperature. Subsequently, 2-chloro-4-nitrophenol (17.4 g, 0.1 mol) and potassium iodide (KI, 0.83 g, 5 mol%) were added, and the reaction mixture was stirred for 12 hours at 60 °C. After completion of the reaction, the reaction mixture was diluted with water (400 mL), the resulting solid was collected by filtration, washed with water and dried to afford 2-((2-chloro-4-nitrophenoxy)methyl)pyridine (26 g, 98% yield) as a white solid. The melting point of the product was 149.2-149.9 °C; mass spectra (MS-EI) m/z: 92, 229, 263 (M+).
References
[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 11, p. 3090 - 3104
[2] Patent: US2016/214964, 2016, A1. Location in patent: Paragraph 0138
[3] Patent: WO2005/10008, 2005, A1. Location in patent: Page/Page column 114-115
[4] Patent: WO2006/23843, 2006, A2. Location in patent: Page/Page column 64
[5] Patent: US2010/298297, 2010, A1. Location in patent: Page/Page column 14
2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine manufacturers
- Product
- 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine 179687-79-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 2000
- Release date
- 2025-04-29
- Product
- 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine 179687-79-7
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-07-31