3-chloro-4-(pyridin-2-ylmethoxy)aniline

ChemicalBook > CAS DataBase List > 3-chloro-4-(pyridin-2-ylmethoxy)aniline

3-chloro-4-(pyridin-2-ylmethoxy)aniline

Product Name: 3-chloro-4-(pyridin-2-ylmethoxy)aniline
CAS No.: 524955-09-7
Chemical Name: 3-chloro-4-(pyridin-2-ylmethoxy)aniline
Synonyms: 3-Chloro-4-[(pyridin-2-yl)Methyloxy]aniline;3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-BENZENAMINE;AKOS B033273;methoxy)aniL;oro-4-(2-pyridyL;ART-CHEM-BB B033273;Neratinib Impurity 41;UKRORGSYN-BB BBV-019513;Neratinib Intermediate1;AKOS B033273(524955-09-7)
CBNumber: CB4801557
Molecular Formula: C12H11ClN2O
Formula Weight: 234.68
MOL File: 524955-09-7.mol

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3-chloro-4-(pyridin-2-ylmethoxy)aniline Property

Melting point:: 91.0 to 95.0 °C
Boiling point:: 402.5±35.0 °C(Predicted)
Density: 1.292±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: powder to crystal
pka: 3.88±0.10(Predicted)
color: White to Light yellow to Light orange

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3150
Product name: 3-Chloro-4-(2-pyridylmethoxy)aniline
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $152
Updated: 2024/03/01

TCI Chemical

Product number: C3150
Product name: 3-Chloro-4-(2-pyridylmethoxy)aniline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $456
Updated: 2024/03/01

TRC

Product number: C429263
Product name: 3-Chloro-4-(2-pyridylmethoxy)aniline
Packaging: 5g
Price: $70
Updated: 2021/12/16

TRC

Product number: C429263
Product name: 3-Chloro-4-(2-pyridylmethoxy)aniline
Packaging: 10g
Price: $110
Updated: 2021/12/16

TRC

Product number: C429263
Product name: 3-Chloro-4-(2-pyridylmethoxy)aniline
Packaging: 1g
Price: $45
Updated: 2021/12/16

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3-chloro-4-(pyridin-2-ylmethoxy)aniline Chemical Properties,Usage,Production

Uses

3-Chloro-4-(2-pyridylmethoxy)aniline was used for preparation of disubstituted (arylamino)quinolinecarbonitriles as orally active irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents.

Synthesis

3-chloro-4-(pyridin-2-ylmethoxy)aniline is synthesised using 2-((2-Chloro-4-nitrophenoxy)methyl)pyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
The 2-((2-chloro-4-nitrophenoxy)methyl)pyridine (3.9 g, 15 mmol), zinc powder (5.8 g, 88 mmol) and ammonium chloride (2.4 g, 44 mmol) were added into a mixed solution of ethanol (60 mL) and H2O (10 mL). The mixture was stirred at 60° C. overnight. Then the reaction mixture was poured into 200 mL of H2O, extracted with ethyl acetate. The organic phase was separated, washed with saturated brine and dried. The solvent was removed in vacuo, and the compound shown in the title (3.4 g, 98percent) was obtained. 1H NMR (CDCl3): δ 8.57 (1H, d, J=4.8 Hz), 7.75-7.70 (1H, m), 7.65-7.63 (1H, m), 7.23-7.20 (1H, m), 6.81 (1H, d, J=9.2 Hz), 6.77 (1H, d, J=2.8 Hz), 5.18 (2H, s), 3.48 (2H, br).

3-chloro-4-(pyridin-2-ylmethoxy)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-chloro-4-(pyridin-2-ylmethoxy)aniline manufacturers

Nanjing Fred Technology Co., Ltd

Product: 3-chloro-4-(pyridin-2-ylmethoxy)aniline 524955-09-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-22

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3-chloro-4-(pyridin-3-ylMethoxy)aniline 524955-09-7
Price: US $0.00-0.00/Kg/Bag
Min. Order: 100g
Purity: 98%min
Supply Ability: 100kg
Release date: 2021-12-01

Henan Aochuang Chemical Co.,Ltd.

Product: 3-chloro-4-(pyridin-3-ylMethoxy)aniline 524955-09-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

524955-09-7, 3-chloro-4-(pyridin-2-ylmethoxy)anilineRelated Search:

n-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl) acetamide 6-amino-4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-7-ethoxyquinoline-3-carbonitrile 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine Neratinib 2-(CHLOROMETHYL)ALLYLTRICHLOROSILANE 3-Bromofuran 6-AMino-4-((3-chloro-4-(pyridin-2-ylMethoxy)phenyl)aMino)-7-ethoxyquinoline-3-carbonitrile (Hydrochloride) 2-(4-Nitro-2-ethoxyphenyl)pthaliMide N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide 2-(4-AMino-2-ethoxyphenyl)pthaliMide 6-AMINO-4-CHLORO-7-ETHOXYQUINOLINE-3-CARBONITRILE 6-fluoroquinoline-3-carbonitrile 3-METHOXYPYRIDINE 4-Chloro-3-cyano-7-ethoxy-6-nitroquinoline 2-Amino-5-chloropyridine-3-carboxylic acid 4-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)-2-Pyridinamine 3-chloro-4-(pyridin-2-ylmethoxy)aniline 3-chloro-4-(pyridin-2-ylmethoxy)aniline

AKOS B033273

3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-BENZENAMINE

3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-PHENYLAMINE

ART-CHEM-BB B033273

UKRORGSYN-BB BBV-019513

3-chloro-4-(2-pyridinylMethoxy)- BenzenaMine

3-Chloro-4-[(pyridin-2-yl)Methoxy]benzenaMine [3-Chloro-4-(pyridin-2-ylMethoxy)phenyl]aMine

BenzenaMine, 3-chloro-4-(2-pyridinylMethoxy)-

3-Chloro-4-[(pyridin-2-yl)Methyloxy]aniline

Neratinib Intermediate1

3-Chloro-4-(pyridin-2-ylmethoxy)

3-Chloro-4-(2-pyridylmethoxy)aniline

3-Chloro-4-(pyridine-2-ylmethoxy)aniline

AKOS B033273(524955-09-7)

4-((pyridin-2-yl)methoxy)-3-chlorobenzenamine

methoxy)aniL

oro-4-(2-pyridyL

AKOS B033273 ISO 9001：2015 REACH

Neratinib Impurity 41

524955-09-7 AKOS B033273

3-Chloro-4-(pyridin-2-ylmethoxy)aniline (Neratinib Impurity)

3-chloro-4-(pyridin-2-ylmethoxy)aniline

524955-09-7