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3-chloro-4-(pyridin-2-ylmethoxy)aniline

Product Name
3-chloro-4-(pyridin-2-ylmethoxy)aniline
CAS No.
524955-09-7
Chemical Name
3-chloro-4-(pyridin-2-ylmethoxy)aniline
Synonyms
3-Chloro-4-[(pyridin-2-yl)Methyloxy]aniline;3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-BENZENAMINE;AKOS B033273;methoxy)aniL;oro-4-(2-pyridyL;ART-CHEM-BB B033273;Neratinib Impurity 41;UKRORGSYN-BB BBV-019513;Neratinib Intermediate1;AKOS B033273(524955-09-7)
CBNumber
CB4801557
Molecular Formula
C12H11ClN2O
Formula Weight
234.68
MOL File
524955-09-7.mol
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3-chloro-4-(pyridin-2-ylmethoxy)aniline Property

Melting point:
91.0 to 95.0 °C
Boiling point:
402.5±35.0 °C(Predicted)
Density 
1.292±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
3.88±0.10(Predicted)
color 
White to Light yellow to Light orange
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3150
Product name
3-Chloro-4-(2-pyridylmethoxy)aniline
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$152
Updated
2024/03/01
TCI Chemical
Product number
C3150
Product name
3-Chloro-4-(2-pyridylmethoxy)aniline
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$456
Updated
2024/03/01
TRC
Product number
C429263
Product name
3-Chloro-4-(2-pyridylmethoxy)aniline
Packaging
5g
Price
$70
Updated
2021/12/16
TRC
Product number
C429263
Product name
3-Chloro-4-(2-pyridylmethoxy)aniline
Packaging
10g
Price
$110
Updated
2021/12/16
TRC
Product number
C429263
Product name
3-Chloro-4-(2-pyridylmethoxy)aniline
Packaging
1g
Price
$45
Updated
2021/12/16
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3-chloro-4-(pyridin-2-ylmethoxy)aniline Chemical Properties,Usage,Production

Uses

3-Chloro-4-(2-pyridylmethoxy)aniline was used for preparation of disubstituted (arylamino)quinolinecarbonitriles as orally active irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents.

Synthesis

3-chloro-4-(pyridin-2-ylmethoxy)aniline is synthesised using 2-((2-Chloro-4-nitrophenoxy)methyl)pyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
The 2-((2-chloro-4-nitrophenoxy)methyl)pyridine (3.9 g, 15 mmol), zinc powder (5.8 g, 88 mmol) and ammonium chloride (2.4 g, 44 mmol) were added into a mixed solution of ethanol (60 mL) and H2O (10 mL). The mixture was stirred at 60° C. overnight. Then the reaction mixture was poured into 200 mL of H2O, extracted with ethyl acetate. The organic phase was separated, washed with saturated brine and dried. The solvent was removed in vacuo, and the compound shown in the title (3.4 g, 98percent) was obtained. 1H NMR (CDCl3): δ 8.57 (1H, d, J=4.8 Hz), 7.75-7.70 (1H, m), 7.65-7.63 (1H, m), 7.23-7.20 (1H, m), 6.81 (1H, d, J=9.2 Hz), 6.77 (1H, d, J=2.8 Hz), 5.18 (2H, s), 3.48 (2H, br).

3-chloro-4-(pyridin-2-ylmethoxy)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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3-chloro-4-(pyridin-2-ylmethoxy)aniline Suppliers

Americas 1 Canada 1 China 224 Europe 1 Germany 1 India 11 Japan 1 United Kingdom 4 United States 16 Global 260
Toronto Research Chemicals Inc.
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6668
Advantage
58
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View Lastest Price from 3-chloro-4-(pyridin-2-ylmethoxy)aniline manufacturers

Nanjing Fred Technology Co., Ltd
Product
3-chloro-4-(pyridin-2-ylmethoxy)aniline 524955-09-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-22
WUHAN FORTUNA CHEMICAL CO., LTD
Product
3-chloro-4-(pyridin-3-ylMethoxy)aniline 524955-09-7
Price
US $0.00-0.00/Kg/Bag
Min. Order
100g
Purity
98%min
Supply Ability
100kg
Release date
2021-12-01
Henan Aochuang Chemical Co.,Ltd.
Product
3-chloro-4-(pyridin-3-ylMethoxy)aniline 524955-09-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30

524955-09-7, 3-chloro-4-(pyridin-2-ylmethoxy)anilineRelated Search:

n-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl) acetamide 6-amino-4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-7-ethoxyquinoline-3-carbonitrile 2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine Neratinib 2-(CHLOROMETHYL)ALLYLTRICHLOROSILANE 3-Bromofuran 6-AMino-4-((3-chloro-4-(pyridin-2-ylMethoxy)phenyl)aMino)-7-ethoxyquinoline-3-carbonitrile (Hydrochloride) 2-(4-Nitro-2-ethoxyphenyl)pthaliMide N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide 2-(4-AMino-2-ethoxyphenyl)pthaliMide 6-AMINO-4-CHLORO-7-ETHOXYQUINOLINE-3-CARBONITRILE 6-fluoroquinoline-3-carbonitrile 3-METHOXYPYRIDINE 4-Chloro-3-cyano-7-ethoxy-6-nitroquinoline 2-Amino-5-chloropyridine-3-carboxylic acid 4-(4-amino-2-fluorophenoxy)-3-chloro-N-(diphenylmethylene)-2-Pyridinamine 3-chloro-4-(pyridin-2-ylmethoxy)aniline 3-chloro-4-(pyridin-2-ylmethoxy)aniline

  • AKOS B033273
  • 3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-BENZENAMINE
  • 3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-PHENYLAMINE
  • ART-CHEM-BB B033273
  • UKRORGSYN-BB BBV-019513
  • 3-chloro-4-(2-pyridinylMethoxy)- BenzenaMine
  • 3-Chloro-4-[(pyridin-2-yl)Methoxy]benzenaMine [3-Chloro-4-(pyridin-2-ylMethoxy)phenyl]aMine
  • BenzenaMine, 3-chloro-4-(2-pyridinylMethoxy)-
  • 3-Chloro-4-[(pyridin-2-yl)Methyloxy]aniline
  • Neratinib Intermediate1
  • 3-Chloro-4-(pyridin-2-ylmethoxy)
  • 3-Chloro-4-(2-pyridylmethoxy)aniline
  • 3-Chloro-4-(pyridine-2-ylmethoxy)aniline
  • AKOS B033273(524955-09-7)
  • 4-((pyridin-2-yl)methoxy)-3-chlorobenzenamine
  • methoxy)aniL
  • oro-4-(2-pyridyL
  • AKOS B033273 ISO 9001：2015 REACH
  • Neratinib Impurity 41
  • 524955-09-7 AKOS B033273
  • 3-Chloro-4-(pyridin-2-ylmethoxy)aniline (Neratinib Impurity)
  • 3-chloro-4-(pyridin-2-ylmethoxy)aniline
  • 3-chloro-4-(2-pyridinylmethoxy) benzeneamine
  • 524955-09-7
  • 524955-09-7