ChemicalBook > CAS DataBase List > Avdoralimab
Avdoralimab
- Product Name
- Avdoralimab
- CAS No.
- 2226393-85-5
- Chemical Name
- Avdoralimab
- Synonyms
- Avdoralimab;Avdoralimab (anti-C5AR1);Research Grade Avdoralimab;Research Grade Avdoralimab (DHD47201)
- CBNumber
- CB48081160
- Formula Weight
- 0
- MOL File
- Mol file
More
Less
Avdoralimab Property
- form
- Liquid
- color
- Colorless to light yellow
More
Less
Avdoralimab Chemical Properties,Usage,Production
Uses
Avdoralimab (IPH 5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1 (C5aR1) that prevents its binding to C5a. Avdoralimab can be used for complement-driven inflammatory diseases and solid tumours research[1].
in vivo
In mice with a knock in for human C5aR1 (HuC5aR1 KI mice), Avdoralimab blocks the infiltration of neutrophils and monocytes, prevents albumin release in broncho-alveolar lavage fluid (BALF) and limits C5a-induced acute lung injury (ALI) histopathological features[1].
References
[1] Julien Carvelli, et al. Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis. Nature. 2020 Dec;588(7836):146-150. DOI:10.1038/s41586-020-2600-6
Avdoralimab Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Avdoralimab Suppliers
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
2226393-85-5, AvdoralimabRelated Search:
Depemokimab
Befovacimab
Research Grade Clivatuzumab (DHD14205)
Laprituximab
Tuvirumab
Alsevalimab
Ebdarokimab
Rosmantuzumab
Iscalimab
Siplizumab