3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine

Product Name: 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
CAS No.: 486460-20-2
Chemical Name: 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
Synonyms: 3-(TRIFLUOROMETHYL)-1,2,4-TRIAZOLO[4,3-A]-PYRAZINE;1,2,4-Triazolo[4,3-a]pyrazine, 3-(trifluoromethyl)-;3-(TRIFLUOROMETHYL)-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE,95% MIN(HPLC)
CBNumber: CB4838863
Molecular Formula: C6H3F3N4
Formula Weight: 188.11
MOL File: 486460-20-2.mol

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3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Property

Density: 1.69±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -2.40±0.30(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: T792455
Product name: 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine
Packaging: 10mg
Price: $660
Updated: 2021/12/16

TRC

Product number: T792455
Product name: 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine
Packaging: 5mg
Price: $345
Updated: 2021/12/16

AK Scientific

Product number: X6641
Product name: 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine
Packaging: 10g
Price: $1616
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0011921
Product name: 3-(TRIFLUOROMETHYL)-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE
Purity: 95.00%
Packaging: 5G
Price: $1668.98
Updated: 2021/12/16

Matrix Scientific

Product number: 097620
Product name: 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine
Purity: 95+%
Packaging: 250mg
Price: $435
Updated: 2021/12/16

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3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Chemical Properties,Usage,Production

Uses

3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine can be used as reactant/reagent in synthetic preparation of 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for treatment or prevention of diabetes.

Synthesis

1447800-65-8

486460-20-2

General method: 10 mmol of compound 3 (CAS:1447800-65-8) was dissolved in 50 mL of toluene and 20 mmol of triethylamine was slowly added to the reaction system at room temperature with continuous stirring for 1 hour. The reaction process was monitored by thin layer chromatography (TLC). After the reaction was complete, the reaction mixture was slowly poured into 25 g of ice-water mixture, stirred thoroughly and left to stratify. The organic phase was separated and washed with 2 x 10 mL of cold water, followed by drying the organic phase with anhydrous sodium sulfate. Finally, the organic phase was concentrated under reduced pressure to give compound 4 in good yield.

References

[1] Letters in Organic Chemistry, 2013, vol. 10, # 5, p. 348 - 352

3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution Polyphosphoric acid Trifluoroacetic anhydride 2-Chloropyrazine

Preparation Products

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3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Suppliers

China 68 India 3 United Kingdom 1 United States 9 Global 81

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View Lastest Price from 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3-(Trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine 486460-20-2
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Career Henan Chemical Co

Product: 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine 486460-20-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-03

486460-20-2, 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazineRelated Search:

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3-(TRIFLUOROMETHYL)-1,2,4-TRIAZOLO[4,3-A]-PYRAZINE

3-(TRIFLUOROMETHYL)-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE,95% MIN(HPLC)

1,2,4-Triazolo[4,3-a]pyrazine, 3-(trifluoromethyl)-

486460-20-2

486460-53-7

C6H3F3N4