Penicillin G potassium salt Property

Melting point:

214-217 C

alpha 

D22 +285° (c = 0.748 in water)

refractive index 

294 ° (C=1, H2O)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

H₂O: 100 mg/mL

form 

powder

color 

Needles from butanol (aq)

PH

pH (10g/L, 25℃) : 5.0～7.5

Water Solubility 

Soluble in water (100 mg/ml), methanol, ethanol (sparingly), and alcohol. Insoluble in chloroform.

Merck 

14,7094

BRN 

3832841

Stability:

Hygroscopic

InChIKey

IYNDLOXRXUOGIU-LQDWTQKMSA-M

SMILES

N12C([C@@H](NC(=O)CC3=CC=CC=C3)[C@@]1([H])SC(C)(C)[C@@H]2C([O-])=O)=O.[K+] |&1:2,13,19,r|

EPA Substance Registry System

Penicillin G Potassium (113-98-4)

Safety

Hazard Codes 

Xn,C,F

Risk Statements 

42/43-34-11

Safety Statements 

36/37-45-36/37/39-26-16-60-37-24-22

WGK Germany 

2

RTECS 

XH9700000

F 

10-23

TSCA 

Yes

HS Code 

29411000

Toxicity

LD50 oral in rabbit: 5848mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

Penicillin G potassium salt Chemical Properties,Usage,Production

Description

Benzylpenicillin potassiumwas the first crystalline penicillin produced on an industrial scale , . It is produced in the pure state by the addition of phenylacetate to a culture of Penicillium chrysogenum. The crystalline benzylpenicillin potassium contains 1598 U/mg.

Chemical Properties

Penicillin G potassium salt is also known as Potassium benzylpenicillin, it is white crystalline powder, odorless or slightly specific odor, hygroscopic. Soluble in water, physiological saline, glucose solution. The aqueous solution of it is easy to fail when placed at room temperature, and it will fail rapidly in the presence of acid, alkali, oxidant, etc. Penicillin G potassium salt has good antibacterial effect on Streptococcus such as Streptococcus hemolyticus, Streptococcus pneumoniae and Staphylococcus without penicillinase.

Uses

Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. Penicillin G potassium salt is used as a cell culture additive as an antibiotics. Use to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans.

Preparation

Penicillin G potassium salt is a highly effective and low toxicity antibiotic, which is obtained by salt formation of Chlorpheniramine maleate and maleic acid.

Definition

ChEBI: Penicillin G potassium salt is organic potassium salt of benzylpenicillin. It is an antibiotic substance produced by Penicillium sp. Antibacterial. It contains a benzylpenicillin(1-).

brand name

Pentids (Apothecon); Pfizerpen (Pfizer).

General Description

Penicillin G Potassium is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic. Penicillin G potassium binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, which is a critical component of the bacterial cell wall. This leads to the interruption of cell wall synthesis, consequently leading to bacterial cell growth inhibition and cell lysis.

Biochem/physiol Actions

Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.
Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.

Safety Profile

Poison by intracerebral andintravenous routes. Moderately toxic by intraperitonealroute. Mutation data reported. See other penicillin entries.When heated to decomposition it emits toxic fumes ofNOx and SOx.