ChemicalBook > CAS DataBase List > (5-Chloro-3-pyridinyl)methanol

(5-Chloro-3-pyridinyl)methanol

Product Name: (5-Chloro-3-pyridinyl)methanol
CAS No.: 22620-34-4
Chemical Name: (5-Chloro-3-pyridinyl)methanol
Synonyms: 5-Chloro-3-pyridinemethanol;3-Pyridinemethanol, 5-chloro-;(5-Chloro-3-pyridinyl)methanol;(5-Chloro-pyridin-3-yl)-methanol;(5-Chloro-3-pyridinyl)methanol ISO 9001：2015 REACH
CBNumber: CB4947868
Molecular Formula: C6H6ClNO
Formula Weight: 143.57
MOL File: 22620-34-4.mol

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(5-Chloro-3-pyridinyl)methanol Property

Boiling point:: 258.8±25.0 °C(Predicted)
Density: 1.324±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: solid
pka: 13.32±0.10(Predicted)
color: Yellow
InChIKey: ALUCWNPKIRQBEF-UHFFFAOYSA-N

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: MNO000182
Product name: (5-Chloro-3-pyridinyl)methanol
Packaging: 1g
Price: $308
Updated: 2023/01/07

TRC

Product number: C381658
Product name: (5-Chloro-3-pyridinyl)methanol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR480255
Product name: (5-Chloro-3-pyridinyl)methanol
Purity: 97%
Packaging: 250mg
Price: $67
Updated: 2021/12/16

AK Scientific

Product number: V0671
Product name: (5-Chloro-3-pyridinyl)methanol
Packaging: 250mg
Price: $131
Updated: 2021/12/16

Apolloscientific

Product number: OR480255
Product name: (5-Chloro-3-pyridinyl)methanol
Purity: 97%
Packaging: 1g
Price: $132
Updated: 2021/12/16

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(5-Chloro-3-pyridinyl)methanol Chemical Properties,Usage,Production

Uses

(5-Chloro-3-Pyridinyl)Methanol is used in preparation of piperidines or piperidones substituted with urea and heteroaryl as FPR2 modulators.

Synthesis

51269-81-9

22620-34-4

General procedure for the synthesis of 5-chloro-3-pyridinemethanol from 5-chloronicotinic acid methyl ester: Sodium borohydride (16.4 g, 434 mmol) was slowly added to a mixed solution of 5-chloronicotinic acid methyl ester (17.2 g, 101 mmol) in methanol (230 mL) and dichloromethane (230 mL) at 0 °C. The reaction mixture was stirred continuously for 18 hours at room temperature. Upon completion of the reaction, the mixture was concentrated under reduced pressure and subsequently diluted with deionized water (300 mL) and extracted with ethyl acetate (3 x 300 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford the target product 5-chloro-3-pyridinemethanol (7.8 g, 54% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.45-8.52 (m, 2H), 7.83 (s, 1H), 5.45 (t, J = 5.8 Hz, 1H), 4.55 (t, J = 5.7 Hz, 2H). Mass spectral analysis showed m/z of 144.1 [M+H]+.

References

[1] Patent: US2014/107340, 2014, A1. Location in patent: Paragraph 0124
[2] Patent: WO2009/6370, 2009, A1. Location in patent: Page/Page column 28

(5-Chloro-3-pyridinyl)methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (5-Chloro-3-pyridinyl)methanol manufacturers

Henan Fengda Chemical Co., Ltd

Product: (5-Chloro-3-pyridinyl)methanol 22620-34-4
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-02

Shanghai Rlavie Technology Co ltd

Product: (5-Chloro-3-pyridinyl)methanol 22620-34-4
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: (5-Chloro-3-pyridinyl)methanol
Release date: 2021-11-27

Dideu Industries Group Limited

Product: (5-Chloro-3-pyridinyl)methanol 22620-34-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-28

22620-34-4, (5-Chloro-3-pyridinyl)methanolRelated Search:

Clopidol 2-Chloro-5-chloromethylpyridine Chloroacetaldehyde dimethyl acetal 3-Pyridinemethanol Methanol 2-(Hydroxymethyl)pyridine 4-Pyridylcarbinol Pentachloropyridine 2-Chloro-3-hydroxypyridine 5-Chloro-6-hydroxy-3-pyridinecarboxylic acid 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester 5-Chloronicotinic acid 5-Chloro-2-hydroxynicotinic acid 5,6-Dichloronicotinic acid pyridinium Chlorochromate Difluorochloromethane (2-CHLORO-4-PYRIDINYL)METHANOL (4-chloro-2-pyridinyl)methanol

(5-Chloro-3-pyridinyl)methanol

(5-Chloro-pyridin-3-yl)-methanol

5-Chloro-3-pyridinemethanol

3-Pyridinemethanol, 5-chloro-

(5-Chloro-3-pyridinyl)methanol ISO 9001：2015 REACH

22620-34-4

Heterocyclic Compounds

Pyridine