4-Benzothiazolol

Product Name: 4-Benzothiazolol
CAS No.: 7405-23-4
Chemical Name: 4-Benzothiazolol
Synonyms: NSC 403244;4-Benzothiazolol;Benzothiazol-4-ol;benzo[d]thiazol-4-ol;1,3-benzothiazol-4-ol;4-hydroxy-benzothiazol;4-hydroxybenzothiazole;4-Benzothiazolol(6CI,8CI,9CI);4-Benzothiazolol(saMeasBTA-4-0651)
CBNumber: CB51040815
Molecular Formula: C7H5NOS
Formula Weight: 151.19
MOL File: 7405-23-4.mol

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4-Benzothiazolol Property

Melting point:: 143℃
Boiling point:: 312℃
Density: 1.444
Flash point:: 142℃
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 7.71±0.40(Predicted)
color: Light green to green
InChI: InChI=1S/C7H5NOS/c9-5-2-1-3-6-7(5)8-4-10-6/h1-4,9H
InChIKey: NZFKDDMHHUEVPI-UHFFFAOYSA-N
SMILES: S1C2=CC=CC(O)=C2N=C1

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Safety

HS Code: 2934208090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B410608
Product name: Benzo[d]thiazol-4-ol
Packaging: 100mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B410608
Product name: Benzo[d]thiazol-4-ol
Packaging: 500mg
Price: $220
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140775
Product name: Benzo[d]thiazol-4-ol
Packaging: 500mg
Price: $260
Updated: 2021/12/16

Matrix Scientific

Product number: 119028
Product name: Benzo[d]thiazol-4-ol
Purity: 95+%
Packaging: 250mg
Price: $324
Updated: 2021/12/16

AK Scientific

Product number: Z5086
Product name: Benzo[d]thiazol-4-ol
Packaging: 5g
Price: $398
Updated: 2021/12/16

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4-Benzothiazolol Chemical Properties,Usage,Production

Uses

Benzo[d]thiazol-4-ol is a constituent of pheomelanin; a polymeric skin-?centered pigment which acts as a natural photoprotector against harmful solar-?UV radiation.

Synthesis

3048-46-2

7405-23-4

General procedure for the synthesis of 4-hydroxybenzothiazole from 4-methoxybenzothiazole: Boron bromide (3.09 mL, 1M DCM solution, 3.09 mmol) was slowly added dropwise to a stirring solution of 4-methoxybenzothiazole (510 mg, 3.09 mmol) in anhydrous dichloromethane (30 mL) at 0 °C. The reaction mixture was gradually warmed to 40 °C and stirred continuously overnight. Upon completion of the reaction, the solution was concentrated under vacuum and subsequently diluted with water and 2N hydrochloric acid. The aqueous phase was neutralized to pH 7 with sodium bicarbonate and then extracted with ethyl acetate (3 x 100 mL). The organic extracts were combined, dried with magnesium sulfate, and the solvent was removed under vacuum. The resulting oil was purified by fast chromatography on a silica gel column with the eluent ratio tapered from hexane:ethyl acetate [4:1] to hexane:ethyl acetate [7:3], resulting in 4-hydroxybenzothiazole as a brown solid (730 mg, 80% yield). The NMR hydrogen spectrum (300 MHz, CDCl3) data were as follows: δ 7.59 (1H, s, hydrogen on the thiazole ring), 7.46 (1H, dd, aromatic hydrogen), 7.36 (1H, t, aromatic hydrogen), 7.02 (1H, dd, aromatic hydrogen).

References

[1] Patent: WO2004/43903, 2004, A1. Location in patent: Page 68 - 69
[2] Patent: WO2004/43904, 2004, A1. Location in patent: Page 64 - 65
[3] Patent: WO2004/43931, 2004, A1. Location in patent: Page 42-43
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 21, p. 6199 - 6202
[5] Helvetica Chimica Acta, 1938, vol. 21, p. 709

4-Benzothiazolol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Benzothiazolol Suppliers

China 86 Europe 1 Germany 1 India 3 United Kingdom 2 United States 8 Global 101

Alchem Pharmtech,Inc.

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Aladdin Scientific

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Combi-Blocks Inc.

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Frontier Scientific, Inc.

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Matrix Scientific

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Fragmenta

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Sinova Inc.

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Rintech, Inc.

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ProdList: 3416
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View Lastest Price from 4-Benzothiazolol manufacturers

Career Henan Chemical Co

Product: 4-Benzothiazolol 7405-23-4
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g;1kg； 25kg
Release date: 2020-01-09

7405-23-4, 4-BenzothiazololRelated Search:

4-Methoxy-2-aminobenzothiazole 4-Benzothiazolol,2-amino-(6CI,7CI,9CI) 6-Benzothiazolol,2-methyl-(6CI,7CI,9CI) 6-Benzothiazolol(7CI,8CI,9CI) 2-AMINO-6-BENZOTHIAZOLOL HCL,2-AMINO-6-BENZOTHIAZOLOL HYDROCHLORIDE 5-Benzothiazolol,2-methyl-(6CI,9CI) 4-acetoxy-2-(4-methylphenyl)benzothiazole Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI) 4-METHOXY-6-NITRO-BENZOTHIAZOL-2-YLAMINE 2-AMINO-6-CHLORO-4,7-DIMETHOXYBENZOTHIAZOLE 4-METHOXY-BENZOTHIAZOLE-2,6-DIAMINE 2-Benzothiazolamine,4-ethoxy-(9CI) 2(3H)-Benzothiazolone,4-methoxy-,hydrazone(9CI) Benzothiazole, 4-methoxy-2-methyl- (7CI,8CI,9CI) 2-AMINO-6-NITRO-BENZOTHIAZOL-4-OL 6-Benzothiazolol,2-(methylthio)-(9CI) 4-Benzothiazolol,2,6-diamino-(9CI) 4-Benzothiazolol,2-amino-6-nitro-(9CI)

4-Benzothiazolol

Benzothiazol-4-ol

4-Benzothiazolol(6CI,8CI,9CI)

4-hydroxybenzothiazole

benzo[d]thiazol-4-ol

4-Benzothiazolol(saMeasBTA-4-0651)

1,3-benzothiazol-4-ol

4-hydroxy-benzothiazol

NSC 403244

7405-23-4

BENZOTHIAZOLE