4-(4,6-Dichloropyrimidin-2-yl)morpholine

Product Name: 4-(4,6-Dichloropyrimidin-2-yl)morpholine
CAS No.: 10397-13-4
Chemical Name: 4-(4,6-Dichloropyrimidin-2-yl)morpholine
Synonyms: 2-Morpholine-4,6-dichloropyriMidine;2-Morpholino-4,6-dichloropyrimidine;4,6-dichloro-2-MorpholinopyriMidine;2-Morpholinyl-4,6-dichloropyrimidine;4-(4,6-Dichlorpyrimidin-2-yl)morpholin;4-(4,6-Dichloro-2-pyriMidyl)Morpholine;2-(4-Morpholino)-4,6-dichloropyrimidine;4-(4,6-Dichloropyrimidin-2-yl)morpholine;4-(4,6-Dichloro-2-pyrimidinyl)morpholine;4-(4,6-Dichloro-2-pyrimidyl)morpholine>
CBNumber: CB51041054
Molecular Formula: C8H9Cl2N3O
Formula Weight: 234.08
MOL File: 10397-13-4.mol

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4-(4,6-Dichloropyrimidin-2-yl)morpholine Property

Melting point:: 139.0 to 143.0 °C
Boiling point:: 392.9±52.0 °C(Predicted)
Density: 1.435±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Toluene
form: powder to crystal
pka: -1.07±0.50(Predicted)
color: White to Almost white
InChIKey: OXCOCPRVQUEIOL-UHFFFAOYSA-N

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Safety

HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4069
Product name: 4-(4,6-Dichloro-2-pyrimidyl)morpholine
Purity: >98.0%(GC)
Packaging: 1g
Price: $53
Updated: 2025/07/31

TCI Chemical

Product number: D4069
Product name: 4-(4,6-Dichloro-2-pyrimidyl)morpholine
Purity: >98.0%(GC)
Packaging: 5g
Price: $193
Updated: 2025/07/31

TRC

Product number: D435403
Product name: 4-(4,6-Dichloropyrimidin-2-yl)morpholine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 071110
Product name: 4-(4,6-Dichloropyrimidin-2-yl)morpholine
Purity: 97%
Packaging: 1g
Price: $43
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD153979
Product name: 4-(4,6-Dichloropyrimidin-2-yl)morpholine
Packaging: 1g
Price: $103
Updated: 2021/12/16

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4-(4,6-Dichloropyrimidin-2-yl)morpholine Chemical Properties,Usage,Production

Synthesis

110-91-8

3764-01-0

10397-13-4

52127-83-0

2,4,6-Trichloropyrimidine (5) (3.158 g, 17.22 mmol) was mixed with acetone (60 mL) and the mixture was cooled to 0 °C. Morpholine (7) (1.05 equiv, 1.576 g, 18.09 mmol) was slowly added at 0 °C, followed by stirring of the reaction mixture at 0 °C for 15 min, then warmed up to room temperature and continued stirring for 15 min. The progress of the reaction was monitored by thin layer chromatography (TLC, the unfolding agent was a hexane solution of 20% ethyl acetate). After completion of the reaction, the reaction mixture was concentrated by rotary evaporator and further dried under high vacuum. The crude product was purified by silica gel column chromatography using hexane solution of 20% ethyl acetate as eluent to afford the major regional isomer 2-morpholino-4,6-dichloropyrimidine (10) (3.183 g, 13.6 mmol, 79% yield). Elemental analysis (C8H9N3OCl2) Calculated values: C, 41.05; H, 3.88; measured values: C, 42.27; H, 4.06. 1H-NMR (300 MHz, CDCl3) δ 6.40 (s, 1H), 3.82-3.70 (m, 4H), 3.65 (m, 4H). High Resolution Mass Spectrometry (HRMS) [M]+ Calculated value: C8H9N3OCl2, 234.0201; Measured value: 234.0196. secondary regioisomer 4-(2,6-dichloropyrimidin-4-yl)morpholine (11) (0.806 g, 3.444 mmol, 20% yield). 1H-NMR (300 MHz, CDCl3) δ 6.56 (s, 1H), 3.85-3.60 (m, 8H). 13C-NMR (101MHz, CDCl3) δ 161.75, 160.55, 108.31, 66.59, 44.39. HRMS [M]+ calculated value: C8H9N3OCl2, 234.0201; measured value: 234.0196.

References

[1] Molecules, 2018, vol. 23, # 7, p. 1 - 13
[2] Patent: WO2015/49369, 2015, A1. Location in patent: Page/Page column 48; 49
[3] Patent: WO2016/75130, 2016, A1. Location in patent: Page/Page column 124-125
[4] Patent: WO2017/198347, 2017, A1. Location in patent: Page/Page column 88; 89
[5] Patent: WO2017/198346, 2017, A1. Location in patent: Page/Page column 77; 78

4-(4,6-Dichloropyrimidin-2-yl)morpholine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4,6-Dichloropyrimidin-2-yl)morpholine Suppliers

Americas 1 China 157 Europe 1 Germany 1 India 3 Japan 1 United Kingdom 3 United States 11 Global 178

SiChuang NanBu Honesty Technology Co., Ltd.

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View Lastest Price from 4-(4,6-Dichloropyrimidin-2-yl)morpholine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-(4,6-Dichloropyrimidin-2-yl)morpholine 10397-13-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(4,6-Dichloro-pyriMidin-2-yl)-Morpholine 10397-13-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

Career Henan Chemical Co

Product: 4-(4,6-Dichloropyrimidin-2-yl)morpholine 10397-13-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 500kg
Release date: 2018-08-16

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10397-13-4

C8H9Cl2N3O