4-(4,6-Dichloropyrimidin-2-yl)morpholine
- Product Name
- 4-(4,6-Dichloropyrimidin-2-yl)morpholine
- CAS No.
- 10397-13-4
- Chemical Name
- 4-(4,6-Dichloropyrimidin-2-yl)morpholine
- Synonyms
- 2-Morpholine-4,6-dichloropyriMidine;2-Morpholino-4,6-dichloropyrimidine;4,6-dichloro-2-MorpholinopyriMidine;2-Morpholinyl-4,6-dichloropyrimidine;4-(4,6-Dichlorpyrimidin-2-yl)morpholin;4-(4,6-Dichloro-2-pyriMidyl)Morpholine;2-(4-Morpholino)-4,6-dichloropyrimidine;4-(4,6-Dichloropyrimidin-2-yl)morpholine;4-(4,6-Dichloro-2-pyrimidinyl)morpholine;4-(4,6-Dichloro-2-pyrimidyl)morpholine>
- CBNumber
- CB51041054
- Molecular Formula
- C8H9Cl2N3O
- Formula Weight
- 234.08
- MOL File
- 10397-13-4.mol
4-(4,6-Dichloropyrimidin-2-yl)morpholine Property
- Melting point:
- 139.0 to 143.0 °C
- Boiling point:
- 392.9±52.0 °C(Predicted)
- Density
- 1.435±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Toluene
- form
- powder to crystal
- pka
- -1.07±0.50(Predicted)
- color
- White to Almost white
- InChIKey
- OXCOCPRVQUEIOL-UHFFFAOYSA-N
Safety
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D4069
- Product name
- 4-(4,6-Dichloro-2-pyrimidyl)morpholine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $53
- Updated
- 2025/07/31
- Product number
- D4069
- Product name
- 4-(4,6-Dichloro-2-pyrimidyl)morpholine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $193
- Updated
- 2025/07/31
- Product number
- D435403
- Product name
- 4-(4,6-Dichloropyrimidin-2-yl)morpholine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 071110
- Product name
- 4-(4,6-Dichloropyrimidin-2-yl)morpholine
- Purity
- 97%
- Packaging
- 1g
- Price
- $43
- Updated
- 2021/12/16
- Product number
- FD153979
- Product name
- 4-(4,6-Dichloropyrimidin-2-yl)morpholine
- Packaging
- 1g
- Price
- $103
- Updated
- 2021/12/16
4-(4,6-Dichloropyrimidin-2-yl)morpholine Chemical Properties,Usage,Production
Synthesis
110-91-8
3764-01-0
10397-13-4
52127-83-0
2,4,6-Trichloropyrimidine (5) (3.158 g, 17.22 mmol) was mixed with acetone (60 mL) and the mixture was cooled to 0 °C. Morpholine (7) (1.05 equiv, 1.576 g, 18.09 mmol) was slowly added at 0 °C, followed by stirring of the reaction mixture at 0 °C for 15 min, then warmed up to room temperature and continued stirring for 15 min. The progress of the reaction was monitored by thin layer chromatography (TLC, the unfolding agent was a hexane solution of 20% ethyl acetate). After completion of the reaction, the reaction mixture was concentrated by rotary evaporator and further dried under high vacuum. The crude product was purified by silica gel column chromatography using hexane solution of 20% ethyl acetate as eluent to afford the major regional isomer 2-morpholino-4,6-dichloropyrimidine (10) (3.183 g, 13.6 mmol, 79% yield). Elemental analysis (C8H9N3OCl2) Calculated values: C, 41.05; H, 3.88; measured values: C, 42.27; H, 4.06. 1H-NMR (300 MHz, CDCl3) δ 6.40 (s, 1H), 3.82-3.70 (m, 4H), 3.65 (m, 4H). High Resolution Mass Spectrometry (HRMS) [M]+ Calculated value: C8H9N3OCl2, 234.0201; Measured value: 234.0196. secondary regioisomer 4-(2,6-dichloropyrimidin-4-yl)morpholine (11) (0.806 g, 3.444 mmol, 20% yield). 1H-NMR (300 MHz, CDCl3) δ 6.56 (s, 1H), 3.85-3.60 (m, 8H). 13C-NMR (101MHz, CDCl3) δ 161.75, 160.55, 108.31, 66.59, 44.39. HRMS [M]+ calculated value: C8H9N3OCl2, 234.0201; measured value: 234.0196.
References
[1] Molecules, 2018, vol. 23, # 7, p. 1 - 13
[2] Patent: WO2015/49369, 2015, A1. Location in patent: Page/Page column 48; 49
[3] Patent: WO2016/75130, 2016, A1. Location in patent: Page/Page column 124-125
[4] Patent: WO2017/198347, 2017, A1. Location in patent: Page/Page column 88; 89
[5] Patent: WO2017/198346, 2017, A1. Location in patent: Page/Page column 77; 78
4-(4,6-Dichloropyrimidin-2-yl)morpholine Preparation Products And Raw materials
Raw materials
Preparation Products
4-(4,6-Dichloropyrimidin-2-yl)morpholine Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
View Lastest Price from 4-(4,6-Dichloropyrimidin-2-yl)morpholine manufacturers
- Product
- 4-(4,6-Dichloropyrimidin-2-yl)morpholine 10397-13-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- 4-(4,6-Dichloro-pyriMidin-2-yl)-Morpholine 10397-13-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
- Product
- 4-(4,6-Dichloropyrimidin-2-yl)morpholine 10397-13-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 500kg
- Release date
- 2018-08-16