ChemicalBook > CAS DataBase List > 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione

Product Name
3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
CAS No.
827026-45-9
Chemical Name
3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
Synonyms
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione;6-Piperidinedione;4-Nitro LenalidoMide;Lenalidomide Impurity B;Lenalidomide Impurities05;Lenalidomide EP Impurity B;Lenalidomide 4-Nitro Impurity;3-(4-Nitro-1-oxo-1, 3-dihydro-isoindol-;3-dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)-;3-(4-Nitro-1-oxoisoindolin-2-yl)piperidin-2,6-dione
CBNumber
CB51075415
Molecular Formula
C13H11N3O5
Formula Weight
289.24
MOL File
827026-45-9.mol
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3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Property

Melting point:
>250°C (dec.)
Boiling point:
616.6±55.0 °C(Predicted)
Density 
1.546±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
form 
Solid
pka
10.55±0.40(Predicted)
color 
Beige to Brown
InChI
InChI=1S/C13H11N3O5/c17-11-5-4-10(12(18)14-11)15-6-8-7(13(15)19)2-1-3-9(8)16(20)21/h1-3,10H,4-6H2,(H,14,17,18)
InChIKey
JKPJLYIGKKDZDT-UHFFFAOYSA-N
SMILES
N1C(=O)CCC(N2CC3=C(C2=O)C=CC=C3[N+]([O-])=O)C1=O
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Safety

HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
N496395
Product name
4-NitroLenalidomide
Packaging
10mg
Price
$205
Updated
2021/12/16
TRC
Product number
N496395
Product name
4-NitroLenalidomide
Packaging
100mg
Price
$1620
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0079673
Product name
3-(4-NITRO-1-OXO-1,3-DIHYDROISOINDOL-2-YL)PIPERIDINE-2,6-DIONE
Purity
95.00%
Packaging
1G
Price
$2194.5
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
47895
Product name
4-NitroLenalidomide
Packaging
1g
Price
$2400
Updated
2021/12/16
ChemScene
Product number
CS-M1824
Product name
3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
Purity
99.97%
Packaging
10g
Price
$561
Updated
2021/12/16
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3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Chemical Properties,Usage,Production

Chemical Properties

White crystalline

Uses

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione, also known as 4-Nitro Lenalidomide, is a Lenalidomide (L328000) analog. It is an impurity and intermediate of Lenalidomide.

Preparation

3-aminopiperidine-2,6-dione hydrochloride (III) (25 g, 0.15 mol) and dimethyl sulfoxide (150 mL) were charged into 500 mL 3N RBF. Triethylamine (62 g, 0.61 mol) was added slowly to the above reaction mixture under nitrogen over 10 min. Methyl 2-(bromomethyl)-3-nitrobenzoate (II) (45.8 g, 0.16 mol) of example 3 dissolved in dimethyl sulfoxide (50 mL) was added to the reaction mixture under nitrogen over 20 min and heated to 50-55 °C. 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione was obtained by purification.

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Suppliers

Canada 1 China 229 Germany 1 India 22 United Kingdom 1 United States 11 Global 265
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View Lastest Price from 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione manufacturers

SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.
Product
3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione 827026-45-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
9000
Release date
2023-09-07
Henan Aochuang Chemical Co.,Ltd.
Product
3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione 827026-45-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione 827026-45-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

827026-45-9, 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dioneRelated Search:

Lenalidomide Impurity 11 Lenalidomide Impurity 14 Lenalidomide Impurity 3 Methyl 2-bromomethyl-3-nitrobenzoate 2-BROMOMETHYL-4-NITRO-BENZOIC ACID METHYL ESTER Lenalidomide Impurity 13 METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE Lenalidomide Impurity 7 Hydroxy Lenalidomide Methyl 2-methyl-3-nitrobenzoate Lenalidomide Impurity 12 Lenalidomide Impurity 22 Lenalidomide Impurity 17 Methyl 2-(chloromethyl)-3-nitrobenzoate N-Acetyl Lenalidomide Methyl 3-amino-2-methylbenzoate Lenalidomide-d5 2-Methyl-3-nitrobenzoic acid

  • 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
  • 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidin-2,6-dione
  • 4-Nitro LenalidoMide
  • 3-dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)-
  • 6-Piperidinedione
  • 3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
  • 3-(4-nitro-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione
  • 3-(1,3-Dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
  • 3-(4-Nitro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
  • (3S)-3-(4-Nitro-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
  • 2,6-Piperidinedione, 3-(1,3-dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)-
  • Lenalidomide EP Impurity B
  • Lenalidomide 4-Nitro Impurity
  • 3-(1-keto-4-nitro-isoindolin-2-yl)piperidine-2,6-quinone
  • 3-(4-nitro-1-oxo-2-isoindolinyl)piperidine-2,6-dione
  • 3-(7-nitro-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
  • Lenalidomide Impurity B
  • 3-(4-Nitro-1-oxo-1, 3-dihydro-isoindol-
  • 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2
  • 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dio...
  • Lenalidomide Impurities05
  • Lenalidomide Impurity BQ: What is Lenalidomide Impurity B Q: What is the CAS Number of Lenalidomide Impurity B Q: What is the storage condition of Lenalidomide Impurity B
  • 3-(4-Nitro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione (4-Nitro Analogue of Lenalidomide)
  • 3-（4′-Nitroisondoline-1′-One）-1-Piperidine-2,6-Dione
  • 3-(1-Oxo-4-nitro-1,3-Dihydro-isoindole-2-yl)piperidine-2,6-dione
  • 827026-45-9
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