2-Chloropyrimidine-4-carbonitrile

Application

Product Name: 2-Chloropyrimidine-4-carbonitrile
CAS No.: 75833-38-4
Chemical Name: 2-Chloropyrimidine-4-carbonitrile
Synonyms: 2-Amino-4-cyanopyrimidine;2-chloro-4-cyanopyrmidine;2-Chloro-4-cyanopyrimidine;2-ChloropyriMidine-4-carb...;2-Chloro-4-pyrimidinecarbonitrile;4-PyriMidinecarbonitrile,2-chloro-;4-Pyrimidinecarbonitrile, 2-chloro- (7CI,9CI);2-Chloropyrimidine-4-carbonitrile ISO 9001：2015 REACH;2-Chloro-4-cyanopyrimidine, 2-Chloro-4-cyano-1,3-diazine
CBNumber: CB51081915
Molecular Formula: C5H2ClN3
Formula Weight: 139.54
MOL File: 75833-38-4.mol

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2-Chloropyrimidine-4-carbonitrile Property

Melting point:: 53-55°
Boiling point:: 331.3±15.0 °C(Predicted)
Density: 1.43
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder
pka: -4.96±0.20(Predicted)
color: Off-white to faint yellow/beige
InChI: InChI=1S/C5H2ClN3/c6-5-8-2-1-4(3-7)9-5/h1-2H
InChIKey: HXVQPZSXXYOZMP-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(C#N)=N1

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37
RIDADR: 3439
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C428463
Product name: 2-Chloropyrimidine-4-carbonitrile
Packaging: 1g
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 295671
Product name: 2-Chloro-4-pyrimidinecarbonitrile
Packaging: 250mg
Price: $347
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 37898
Product name: 2-Chloropyrimidine-4-carbonitrile
Purity: 95+%
Packaging: 1g
Price: $365
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC57397
Product name: 2-Chloro-4-pyrimidinecarbonitrile
Packaging: 5G
Price: $420
Updated: 2021/12/16

Matrix Scientific

Product number: 047834
Product name: 2-Chloro-4-pyrimidinecarbonitrile
Purity: >95%
Packaging: 25g
Price: $740
Updated: 2021/12/16

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2-Chloropyrimidine-4-carbonitrile Chemical Properties,Usage,Production

Application

2-Chloro-4-cyanopyrimidine can be used to prepare 2-chloropyrimidine-4-carboxylic acid, which is a key intermediate for the treatment of hyperphosphatemia and the synthesis of benzylsulfonamide pyrazole kinase inhibitors. It is widely used in the synthesis of many pharmaceutical intermediates both domestically and internationally, and has a very promising market prospect.

Chemical Properties

Light yellow solid

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 1, p. 130, 1964 DOI: 10.1002/jhet.5570010305

Synthesis

7460-56-2

75833-38-4

General procedure for the synthesis of 2-chloro-4-cyanopyrimidine from 2-hydroxypyrimidine-4-carbaldehyde oxime: (Step 7) A mixture of 2-oxo-1,2-dihydropyrimidine-4-carboxaldehyde oxime (72.6 g) in cold (0°C) phosphorochloride (280 ml) was placed under vigorous stirring and slowly heated until the onset of a vigorous reaction was observed, at which point heating was stopped. After the reactants were completely dissolved, N,N-diethylaniline (36.3 mL) was added and the reaction mixture continued to reflux for 30 minutes. Upon completion of the reaction, it was cooled to room temperature and the phosphoryl chloride was evaporated under reduced pressure. The crude product was quenched with ice water (500 mL) and extracted with dichloromethane (5 x 200 mL). The organic phases were combined, dried over anhydrous sodium sulfate and subsequently concentrated. The residue was purified by short silica gel column chromatography (dichloromethane as eluent). After concentration, the product 2-chloro-4-cyanopyrimidine (63 g, solidified on standing, 86.5% yield) was obtained and used directly in the next reaction.

References

[1] Patent: WO2013/39854, 2013, A1. Location in patent: Page/Page column 39
[2] Patent: WO2005/75468, 2005, A2. Location in patent: Page/Page column 43

2-Chloropyrimidine-4-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloropyrimidine-4-carbonitrile Suppliers

China 157 Europe 1 India 2 South Korea 1 United Kingdom 3 United States 16 Global 180

Pure Chemistry Scientific Inc.

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View Lastest Price from 2-Chloropyrimidine-4-carbonitrile manufacturers

Dideu Industries Group Limited

Product: 2-Chloropyrimidine-4-carbonitrile 75833-38-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-14

Career Henan Chemical Co

Product: 2-Chloropyrimidine-4-Carbonitrile 75833-38-4
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-09

75833-38-4, 2-Chloropyrimidine-4-carbonitrileRelated Search:

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2-Chloropyrimidine-4-carbonitrile ISO 9001：2015 REACH

75833-38-4

Building Blocks

Heterocycle-Pyrimidine series

pharmacetical

PYRIMIDINE