Uses Description Reference
ChemicalBook > CAS DataBase List > 4-Methoxyphenylacetic acid

4-Methoxyphenylacetic acid

Uses Description Reference
Product Name
4-Methoxyphenylacetic acid
CAS No.
104-01-8
Chemical Name
4-Methoxyphenylacetic acid
Synonyms
P-METHOXYPHENYLACETIC ACID;4MPAA;HOMOANISIC ACID;ASISCHEM D13364;HOMO-P-ANISIC ACID;RARECHEM AL BO 0133;p-Anisylacetic acid;4-Methoxyphenylaceti;p-Methioxy-toluicacid;4-Methoxyphenylacetic
CBNumber
CB5113770
Molecular Formula
C9H10O3
Formula Weight
166.17
MOL File
104-01-8.mol
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4-Methoxyphenylacetic acid Property

Melting point:
84-86 °C(lit.)
Boiling point:
140 °C3 mm Hg(lit.)
Density 
1.1708 (rough estimate)
bulk density
440kg/m3
vapor pressure 
0.071Pa at 25℃
refractive index 
1.5101 (estimate)
Flash point:
193°C
storage temp. 
Store below +30°C.
solubility 
6g/l
form 
Crystalline Powder and Chunks
pka
pK1:4.358 (25°C)
color 
White to light yellow
Water Solubility 
6 g/L (20 ºC)
BRN 
1101737
InChIKey
NRPFNQUDKRYCNX-UHFFFAOYSA-N
LogP
1.295 at 25℃
CAS DataBase Reference
104-01-8(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneacetic acid, 4-methoxy-(104-01-8)
EPA Substance Registry System
Benzeneacetic acid, 4-methoxy- (104-01-8)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-20/21/22
Safety Statements 
26-36
WGK Germany 
3
RTECS 
AI8960000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29189090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M19201
Product name
4-Methoxyphenylacetic acid
Purity
ReagentPlus , 99%
Packaging
5g
Price
$45.8
Updated
2024/03/01
Sigma-Aldrich
Product number
M19201
Product name
4-Methoxyphenylacetic acid
Purity
ReagentPlus , 99%
Packaging
100g
Price
$71.9
Updated
2024/03/01
Sigma-Aldrich
Product number
8.21240
Product name
4-Methoxyphenylacetic acid
Purity
for synthesis
Packaging
100g
Price
$76.5
Updated
2022/05/15
TCI Chemical
Product number
M0742
Product name
4-Methoxyphenylacetic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$20
Updated
2024/03/01
TCI Chemical
Product number
M0742
Product name
4-Methoxyphenylacetic Acid
Purity
>98.0%(GC)(T)
Packaging
100g
Price
$34
Updated
2024/03/01
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4-Methoxyphenylacetic acid Chemical Properties,Usage,Production

Uses

4-Methoxyphenylacetic Acid is a compound that was found from microbial phenolic metabolites in human feces after the consumption of gin, red wine and dealcholized red wine.

Description

4-METHOXYPHENYLACETIC ACID(104-01-8) is used in organic synthesis as well as pharmaceutical industry, especially used as an intermediate of puerarin. It can also be used as potential plasma biomarkers for early detection of non-small cell lung cancer. It is also used in drug industry as an intermediate to make Dextromethorphan.

Reference

Chen, Yan Ping, Y. M. Chen, and M. Tang. "Solubilities of cinnamic acid, phenoxyacetic acid and 4-methoxyphenylacetic acid in supercritical carbon dioxide." Fluid Phase Equilibria 275.1(2008):33-38.

Chemical Properties

white to light yellow crystalline powder and

Uses

4-Methoxyphenylacetic Acid is a compound that was found from microbial phenolic metabolites in human feces after the consumption of gin, red wine and dealcholized red wine.

Uses

4-Methoxyphenylacetic acid can be used:

  • To prepare methyl 4-methoxyphenylacetate by esterification with dimethyl carbonate using mesoporous sulfated zirconia catalyst.
  • As a ligand to synthesize pharmacologically important dinuclear gallium(III) and phenyltin(IV) carboxylate metal complexes.
  • As a reactant to synthesize hydroxylated (E)-stilbenes by reacting with substituted benzaldehydes via Perkin reaction.

Uses

Preparation of pharmaceuticals, other organic compounds.

Definition

ChEBI: A monocarboxylic acid that is phenylacetic acid carrying a 4-methoxy substituent. It is used as an intermediate for pharmaceuticals and other organic synthesis. It has been found to inhibit the germination of cress and lettuce seeds.

Synthesis Reference(s)

The Journal of Organic Chemistry, 51, p. 4354, 1986 DOI: 10.1021/jo00373a005
Tetrahedron Letters, 35, p. 133, 1994 DOI: 10.1016/0040-4039(94)88182-0

General Description

Pale yellow or off white colored flakes. Severely irritates skin and eyes. May be toxic by ingestion.

Reactivity Profile

Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in 4-Methoxyphenylacetic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Flammability and Explosibility

Not classified

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Crystallise the acid from EtOH/water, EtOAc/pet ether (m 87o) or *C6H6/pet ether (m 84-86o). [Beilstein 10 III 431, 10 IV 544.] The acid chloride [4693-91-8] has M 184.6, b 143o/10mm, d 254

4-Methoxyphenylacetic acid Preparation Products And Raw materials

Raw materials

4'-Methoxyacetophenone PIPERAZINE HEXAHYDRATE

Preparation Products

2-CHLORO-5-(4-METHOXYPHENYL)PYRIMIDINE 4-METHOXYPHENYLACETYL CHLORIDE
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View Lastest Price from 4-Methoxyphenylacetic acid manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
4-Methoxyphenylacetic acid 104-01-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-12
Hebei Mujin Biotechnology Co.,Ltd
Product
4-Methoxyphenylacetic acid 104-01-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-08-27
Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-Methoxyphenylacetic acid 104-01-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-25

104-01-8, 4-Methoxyphenylacetic acidRelated Search:

(3,4-Dimethoxyphenyl)acetic acid Citric acid Folic acid Stearic acid 2,2-Diphenylacetic acid 4-Methoxyphenylacetic acid nitrile Ethyl 2-(Chlorosulfonyl)acetate 4-Methoxyphenethylamine 2-Hydroxyphenylacetic acid 2-Methylphenylacetic acid Phenethyl phenylacetate 4-Hydroxyphenylacetic acid 4'-Methoxyacetophenone Hyaluronic acid Ascoric Acid Methoxypropiophenone p-Anisaldehyde 4-Methoxyphenylboronic acid

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