ChemicalBook > CAS DataBase List > N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid

N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid

Product Name
N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid
CAS No.
7365-44-8
Chemical Name
N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid
Synonyms
TES;N-TRIS(HYDROXYMETHYL)METHYL-2-AMINOETHANESULFONIC ACID;Tes Buffer;TES,2-[(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]ethanesulfonic acid, N-[Tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid, TES free acid;C05353;Tris TES;8-Fluoro-1;OmniPur TES;TES free acid;3-cd]indol-6-one
CBNumber
CB5114267
Molecular Formula
C6H15NO6S
Formula Weight
229.25
MOL File
7365-44-8.mol
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N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid Property

Melting point:
~225 °C (dec.)
Density 
1.260 (estimate)
refractive index 
1.5500 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
H2O: 1 M at 20 °C, clear, colorless
form 
Crystalline Powder
color 
White
PH Range
6.8 - 8.2
Odor
Odorless
PH
3.5-5.0 (25℃, 1M in H2O)
pka
7.5(at 25℃)
Water Solubility 
SOLUBLE
λmax
λ: 260 nm Amax: 0.055
λ: 280 nm Amax: 0.045
Merck 
14,9176
BRN 
1957061
InChIKey
JOCBASBOOFNAJA-UHFFFAOYSA-N
CAS DataBase Reference
7365-44-8(CAS DataBase Reference)
EPA Substance Registry System
Ethanesulfonic acid, 2-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]- (7365-44-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
1
TSCA 
Yes
HS Code 
29221980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.05147
Product name
OmniPur® TES
Purity
TES, CAS 7365-44-8 , is a Zwitterionic buffer that is useful in the pH range of 6.8-8.2.
Packaging
100G
Price
$176
Updated
2024/03/01
Sigma-Aldrich
Product number
5.05147
Product name
OmniPur® TES
Purity
TES, CAS 7365-44-8 , is a Zwitterionic buffer that is useful in the pH range of 6.8-8.2.
Packaging
1KG
Price
$985
Updated
2024/03/01
Sigma-Aldrich
Product number
93359
Product name
TES
Purity
BioUltra, ≥99.5% (calc. based on dry substance, T)
Packaging
25g
Price
$246
Updated
2023/06/20
Sigma-Aldrich
Product number
93359
Product name
TES
Purity
BioUltra, ≥99.5% (calc. based on dry substance, T)
Packaging
100g
Price
$589
Updated
2023/06/20
TCI Chemical
Product number
T0683
Product name
N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid [Good's buffer component for biological research]
Purity
>98.0%(T)
Packaging
25g
Price
$107
Updated
2024/03/01
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N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid Chemical Properties,Usage,Production

Chemical Properties

White/clear crystalline powder

Uses

A structural analog to Tris buffer.

Uses

N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid (TES) probably exists in solution as a zwitterion. Because the pKa is 7.4 (physiological pH) this buffer has considerable potential for a variety of biological applications. A buffer using TES free acid can be prepared by titrating the free acid (sc-206102) with sodium hydroxide to the desired pH, using about a half-equivalent of NaOH. Alternatively, solutions of equimolar TES free acid and TES sodium (sc-264384) can be mixed to attain a buffer of the desired pH.  It has been shown to be toxic in vitro, but this toxicity may be due to its ability to form metal chelate complexes that are toxic for cells. TES is a commonly used biological buffering agent.

Definition

ChEBI: N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid is a Good's buffer substance, pKa = 7.5 at 20 ℃. It is a member of ethanolamines, an amino sulfonic acid and a TES. It is functionally related to a taurine. It is a tautomer of a N-tris(hydroxymethyl)methyl-2-ammonioethanesulfonate.

Purification Methods

Crystallise the acid from hot EtOH containing a little water.

N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid Suppliers

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View Lastest Price from N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid manufacturers

Apeloa production Co.,Limited
Product
TES (buffer) 7365-44-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000
Release date
2024-06-05
hebei hongtan Biotechnology Co., Ltd
Product
2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid 7365-44-8
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000
Release date
2024-03-28
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid/TES 7365-44-8
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%-101%
Supply Ability
500KGS
Release date
2021-06-04

7365-44-8, N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic AcidRelated Search:

Tris-MOPS Buffer,10× Sodium Citrate buffer(0.1mol/L, pH4.5, sterile) CHAPS TRIS hydrochloride PBS Tablets Diammonium 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate) Phosphate buffer containing Tween 20 (PBS-T tablets) DIPSO 3-[N,N-Bis(hydroxyethyl)amino]-2-hydroxypropanesulphonic acid sodium salt TAPSO 3-[N-Tris(hydroxymethyl)methylamino]-2-hydroxypropanesulfonic acid sodium salt N-[Tris(hydroxymethyl)methyl]-3-aminopropanesulfonic acid sodium salt TAPS N-(Tris(hydroxymethyl)methyl)-2-aminoethanesulfonic acid sodium salt N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid Tris(hydroxymethyl)aminomethane N-TRIS(HYDROXYMETHYL)METHYL-2-AMINOETHANESULFONIC ACID-D15 2-([2-HYDROXY-1,1-BIS(HYDROXYMETHYL)ETHYL]AMINO)ETHANESULFONIC ACID HEMISODIUM SALT

  • N-[2-HYDROXY-1,1-BIS(HYDROXYMETHYL)ETHYL]TAURINE
  • N-TRIS(HYDROXYMETHYL)METHYL-2-AMINO-ETHANESULPHONIC ACID
  • N-TRIS(HYDROXYMETHYL)METHYL-2-AMINOETHANESULFONIC ACID
  • 2-[TRIS(HYDROXYMETHYL)METHYL]-2-AMINOETHANE SULFONIC ACID
  • 2-[TRIS(HYDROXYMETHYL)METHYLAMINO]-1-ETHANESULFONIC ACID
  • 2-[[TRIS(HYDROXYMETHYL)METHYL]AMINO]ETHANESULFONIC ACID
  • 2-([2-HYDROXY-1,1-BIS(HYDROXYMETHYL)ETHYL]AMINO)ETHANESULFONIC ACID
  • TES free acid
  • 2-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]-ethanesulfonicaci
  • Ethanesulfonicacid,2-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]-
  • N-TRIS(HDYROXYMETHYL)METHYL-2-AMINOETHANESULFONIC ACID ANALYT. GRADE
  • TES,2-[(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]ethanesulfonic acid, N-[Tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid, TES free acid
  • 2-[(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)
  • C05353
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  • <i>N</i>-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
  • TES Vetec(TM) reagent grade, 99%
  • EZNA MICROELUTE GEL EXTRACTION KIT
  • N-[Tris(hydroxymethyl)metyl]-2-aminopropanesulfonic acid
  • Tes Buffer
  • Tris TES
  • TES, BIOPERFORMANCE CERTIFIED, CELL&
  • OmniPur TES
  • 2-(tris(hydroxymethyl)methylamino)ethane-1-sulphonic acid
  • TES, for biochemistry, 99+%
  • Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
  • TES,BIOLOGICALBUFFER
  • 2-(Tris(hydroxymethyl)methylamino)ethan-1-sulfonsure
  • TES FREE ACID SIGMAULTRA
  • TES FREE ACID CELL CULTURE TESTED
  • TES FREE ACID, BIOTECHNOLOGY PERFORMANCE CERTIFIED
  • N-TRIS(HYDROXYMETHYL)METHYL- 2-AMINO-ETHANESULPHONIC ACID (TES) CELL CULTURE REAGENT
  • N-TRIS(HYDROXYMETHYL)METHYL- 2-AMINO-ETHANESULPHONIC ACID (TES) 99+% MOLECULAR BIOLOGY REAGENT
  • N-TRIS(HYDROXYMETHYL)METHYL- 2-AMINO-ETHANESULPHONIC ACID (TES) CRYSTALLINE
  • Tes(N-Tris[Hydroxymethyl]Methyl-2-AminoethanesulfonicAcid)Buffer
  • Tes2-[Tris(Hydroxymethyl)Methylamino]-1-EthanesulfonicAcid
  • N-Tris-(hydroxymethyl)-Methyl-2-Amino Ethansulfonic Acid
  • TES, for biochemistry, 99%
  • N-TRIS(HYDROXYMETHYL)METHYL-2-AMINOETHANESULFONIC ACID TES
  • TES
  • TES (N-(TRIS(HYDROXYMETHYL)METHYL)-2-AMINOETHANESULFONIC ACID)
  • N-Tris-(hydroxymethyl)methyl-2-aminoethanesulphonic acid >99%
  • N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid [Good's buffer component for biological research]
  • N-TRIS(HYDROXYMETHYL)METHYL-2-AMINOETHANE-SULPHONIC ACID extrapure
  • N-[Tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid, TES free acid, 2-[(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]ethanesulfonic acid
  • 2-[[1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]ethanesulfonic acid
  • N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid ,99%
  • TES, 99%, FOR BIOCHEMISTRY
  • 2-[[1,1-Bis(hydroxymethyl)-2-hydroxyethyl]amino]ethanesulfonic acid
  • 2-[1,1-Bis(hydroxymethyl)-2-hydroxyethylamino]ethane-1-sulfonic acid
  • TES【buffering agent】
  • N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid [Good's buffer component for biological research]&gt
  • N-tris(hydroxymethyl)methyl-2-aminoethanesulfonicaci
  • 2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid ISO 9001：2015 REACH
  • N-tris-(Hydroxymethyl)-methyl-2-amino ethansulfonic acid (TES)
  • TES Buffer extrapure, 99%
  • N-Tris(Hydroxymethyl)Methyl-2-Aminoethanesulfonic Acid, for HPLC, Biological Buffer, Fisher Chemical