ChemicalBook > CAS DataBase List > (R)-2-AMINO-3-BENZYLOXY-1-PROPANOL

(R)-2-AMINO-3-BENZYLOXY-1-PROPANOL

Product Name
(R)-2-AMINO-3-BENZYLOXY-1-PROPANOL
CAS No.
58577-87-0
Chemical Name
(R)-2-AMINO-3-BENZYLOXY-1-PROPANOL
Synonyms
SERINOL(BZL);H-SER(BZL)-OL;H-D-SER(BZL)-OL;Ser(bzl)-OL.HCL;Serinol(Bzl)·HCl;H-Ser(Bzl)-ol.HCl;O-BENZYL-L-SERINOL;O-BENZYL-D-SERINOL;H-L-Ser(Bzl)-ol·HCl;L-Serinol(Bzl) hydrochloride
CBNumber
CB5115532
Molecular Formula
C10H15NO2
Formula Weight
181.23
MOL File
58577-87-0.mol
More
Less

(R)-2-AMINO-3-BENZYLOXY-1-PROPANOL Property

Melting point:
34-37 °C (lit.)
Boiling point:
307 °C (lit.)
Density 
1.0918 (rough estimate)
refractive index 
1.5464 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
form 
Oil
pka
12.53±0.10(Predicted)
color 
Clear Colourless
optical activity
[α]20/D +4°, c = 1 in methylene chloride
Sensitive 
Air Sensitive
InChI
InChI=1S/C10H15NO2/c11-10(6-12)8-13-7-9-4-2-1-3-5-9/h1-5,10,12H,6-8,11H2/t10-/m1/s1
InChIKey
ZJUOMDNENVWMPL-SNVBAGLBSA-N
SMILES
C(O)[C@@H](N)COCC1=CC=CC=C1
More
Less

Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-27-36/37/39-45
RIDADR 
3267
WGK Germany 
3
HazardClass 
8
HS Code 
29221990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
473758
Product name
(R)-(+)-2-Amino-3-benzyloxy-1-propanol
Purity
97%
Packaging
1g
Price
$105
Updated
2023/06/20
TRC
Product number
A600205
Product name
(R)-(+)-2-Amino-3-benzyloxy-1-propanol
Packaging
1g
Price
$95
Updated
2021/12/16
Chem-Impex
Product number
03219
Product name
O-Benzyl-L-serinolhydrochloride,≥98%(HPLC)
Purity
≥98%(HPLC)
Packaging
250MG
Price
$36.22
Updated
2021/12/16
Chem-Impex
Product number
03219
Product name
O-Benzyl-L-serinolhydrochloride,98%(HPLC)
Purity
98%(HPLC)
Packaging
1G
Price
$44.8
Updated
2021/12/16
Chem-Impex
Product number
03219
Product name
O-Benzyl-L-serinolhydrochloride,98%(HPLC)
Purity
98%(HPLC)
Packaging
5G
Price
$168
Updated
2021/12/16
More
Less

(R)-2-AMINO-3-BENZYLOXY-1-PROPANOL Chemical Properties,Usage,Production

Chemical Properties

Colorless to yellow liquid or low melting solid

Uses

(R)-(+)-2-Amino-3-benzyloxy-1-propanol is used as a reagent to synthesize beta-amino alcohols, compounds that are used as therapeutic agents to treat heart disease. (R)-(+)-2-Amino-3-benzyloxy-1-propanol is also used as a reagent to synthesize 15-membered macrolide antibiotics, drugs that are used to treat respiratory tract infections.

Synthesis

4726-96-9

58577-87-0

General procedure for the synthesis of O-benzyl-L-serinol from (S)-2-amino-3-(benzyloxy)propionic acid: O-benzyl-L-serine (15.0 g, 76.8 mmol) was slowly added to a tetrahydrofuran (THF, 150 mL) suspension of lithium aluminum hydride (4.37 g, 115.3 mmol) under reflux conditions. The reaction mixture was stirred at reflux temperature for 1.5 h. After cooling in an ice bath, distilled water (4.4 mL), 10% NaOH aqueous solution (4.4 mL), and distilled water (4.4 mL) were added sequentially. After stirring for 18 h at room temperature, the mixture was filtered and the filter cake was washed with THF. The filtrate was concentrated under reduced pressure to remove the solvent, and the residue was purified by silica gel column chromatography (eluent ratio CHCl3/MeOH/NH4OH = 10:1:0.1) to afford the target product, O-benzyl-L-serinol (6.43 g, 69% yield), as a colorless foamy substance. Its physical properties were as follows: [α]27D -5.0 (c 0.760, methanol); 1H NMR (CDCl3) δ 7.27-7.41 (m, 5H), 4.53 (s, 2H), 3.39-3.67 (m, 4H), 3.03-3.17 (m, 1H), 1.85 (br s, 3H); 13C NMR (CDCl3) δ 137.9, 128.2, 127.55, 127.50, 73.1, 72.5, 63.7, 52.3; MS (ESI) m/z 182.2 [M + H]+. The NMR data are in agreement with literature reports.

References

[1] Liebigs Annalen der Chemie, 1988, p. 851 - 854
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 19, p. 5787 - 5801
[3] Tetrahedron, 2002, vol. 58, # 46, p. 9387 - 9401
[4] Tetrahedron, 1975, vol. 31, p. 2629 - 2632
[5] Molecules, 2009, vol. 14, # 12, p. 5124 - 5143

(R)-2-AMINO-3-BENZYLOXY-1-PROPANOL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(R)-2-AMINO-3-BENZYLOXY-1-PROPANOL Suppliers

China 82 India 2 Japan 1 Switzerland 1 United Kingdom 2 United States 10 Global 98
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
ZHIWE CHEMTECH CO LTD
Tel
021-20221225 13917446399
Fax
QQ:115820162
Email
zwchem@163.com
Country
China
ProdList
616
Advantage
61
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
ForeChem (Nantong) Technology Co.,Ltd.
Tel
513-85982855 18921614129
Fax
051385915507
Email
sales@xianxingpharm.com
Country
China
ProdList
2986
Advantage
61
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Suli Pharmaceutical Technology Co., Ltd.
Tel
021-58086325-8060 13636568474
Fax
021-51972827
Email
yingjie.zhang@suli.com
Country
China
ProdList
100
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1991
Advantage
55
Adobe Chem Co., Ltd.
Tel
2332782371
Fax
QQ: 2332782371
Email
adobechem@qq.com
Country
China
ProdList
7980
Advantage
58
Sichuan jiayinglai technology CO.,LTD
Tel
028-028-88457210 18190964009
Fax
QQ3213375147
Email
3054240163@qq.com
Country
China
ProdList
2293
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
Mirro Chemical Co.,Ltd.
Tel
0086-15313090952
Fax
0086-010-80236392
Country
China
ProdList
2355
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16027
Advantage
58
Yujinpharma(Tianjin) Technology Co.,Ltd.
Tel
13370351217 kungfu1217@1
Fax
QQ1400885609
Email
kungfu1217@163.com
Country
China
ProdList
2720
Advantage
58
Hefei Bomei Biotechnology Co., Ltd.
Tel
13739298932
Email
531626407@qq.com
Country
China
ProdList
3010
Advantage
58
Finetech Industry Limited
Tel
+86-27-8746-5837 +8619945049750
Fax
86 27 87772287
Email
info@finetechnology-ind.com
Country
China
ProdList
9629
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
20284
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
Advantage
58
Chengdu Beiyu Pharmaceutical Technology Co., Ltd.
Tel
028-85051141
Email
cao_qin@foxmail.com
Country
CHINA
ProdList
48
Advantage
58
Hubei xin bonus chemical co. LTD
Tel
86-13657291602
Fax
027-59338440
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
22963
Advantage
58
Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd
Tel
037188900765 18037465274
Fax
QQ3430974218
Email
enyawanglei@sina.cn
Country
China
ProdList
13966
Advantage
58
Sichuan Jiaying Lai Technology Co.,LTD
Tel
18716376478
Email
ycling@enlaibio.com
Country
CHINA
ProdList
302
Advantage
58
Chengdu D-innovation Pharmaceutical Co.，LTD
Tel
028-85929779 18881048017
Email
chenxuanruo@d-innovation.com
Country
China
ProdList
262
Advantage
58
Shanghai Jiegu Biotechnology Co., Ltd.
Tel
021-51698675
Email
sales@jiejiegroup.com
Country
China
ProdList
8020
Advantage
58
Chengdu Zhongtian anqing Biotechnology Co., Ltd
Tel
28-85051141 18981748328
Email
lf559@163.com
Country
China
ProdList
42
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
Wuhan Dingxintong Pharmaceutical Co. , Ltd.
Tel
15871722230
Fax
2796190295
Email
15871722230@163.com
Country
China
ProdList
4686
Advantage
58
DONBOO AMINO ACID COMPANY
Tel
+8618051385538
Email
donboo@donboo.com
Country
China
ProdList
9363
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Zhengzhou convergence chemical co., LTD
Tel
0371-0371-55153829 18003835034
Email
2853979819@qq.com
Country
China
ProdList
9998
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39665
Advantage
58
Hubei Weideli Chemical Reagent Co.，Ltd.
Tel
133-3998-5473 13339985473
Email
C13339985473@163.com
Country
China
ProdList
4991
Advantage
58
Shanghai Lingfu Pharmaceutical Research Co. LTD
Tel
+86(21)5895 0110 19945755304
Email
sales@chemany.com
Country
China
ProdList
9984
Advantage
58
Henan Yingtian Biotechnology Co. LTD
Tel
0370-4053511; 18339993703
Email
570581550@qq.com
Country
China
ProdList
963
Advantage
58
Zhengzhou Hong Sheng Pharmaceutical Technology Co. Ltd.
Tel
0371-55695890 15637198702
Email
1677336983@qq.com
Country
China
ProdList
13191
Advantage
58
Sichuan HongRi Pharma-Tech Co., Ltd
Tel
028-02888457210 18380436509
Fax
0838-2822568
Email
2065506070@qq.com
Country
China
ProdList
2025
Advantage
58
Hebei Boxin Biotechnology Co. , Ltd.
Tel
19131160546
Email
2681315246@qq.com
Country
China
ProdList
13199
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50464
Advantage
58
More
Less

View Lastest Price from (R)-2-AMINO-3-BENZYLOXY-1-PROPANOL manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
(R)-2-AMINO-3-BENZYLOXY-1-PROPANOL 58577-87-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-09-28
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
H-L-Ser(Bzl)-OL.HCl 58577-87-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-19
Sichuan Jiaying Lai Technology Co.,LTD
Product
H-Ser(Bzl)-Ol.HCl 58577-87-0
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-25

58577-87-0, (R)-2-AMINO-3-BENZYLOXY-1-PROPANOLRelated Search:

BENZYL 2-ACETAMIDO-2-DEOXY-ALPHA-D-GLUCOPYRANOSIDE 3-FLUORO-5-(TRIFLUOROMETHYL)PHENOL O-BENZYL-L-SERINE Boc-Thr(Bzl)-OH Z-SER(BZL)-OH FMOC-SER(BZL)-OH N-Boc-(S)-2-amino-3-benzyloxy-1-propanol 3-Benzyloxy-1-propanol Benzyl 2-AcetaMido-2-deoxy-3-O-(β-D-galactopyranosyl) α-D-galactopyranoside L-THREONINE BENZYL ESTER BOC-SER(P-CHLORO-BZL)-OH DCHA BENZYL 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSIDE BENZYL 2-ACETAMIDO-2-DEOXY-3,6-DI-O-ACETYL-ALPHA-D-GLUCOPYRANOSIDE BOC-THR(BZL)-ONP AC-ALPHA-BENZYL-4,6-O-BENZYLIDENE-MURAMIC ACID BENZYL-2-ACETAMIDO-2-DEOXY-ALPHA-D-GALACTOPYRANOSIDE BOC-SER(BZL)-OSU BOC-THR(P-CHLORO-BZL)-OH DCHA

  • O-BENZYL-D-SERINOL
  • O-BENZYL-L-SERINOL
  • SERINOL(BZL)
  • (R)-(+)-2-AMINO-3-BENZYLOXY-1-PROPANOL
  • (R)-2-AMINO-3-BENZYLOXY-1-PROPANOL
  • H-D-SER(BZL)-OL
  • H-SER(BZL)-OL
  • Serinol(Bzl)·HCl
  • (R)-(+)-2-Amino-3-benzyloxy-1-propanol,97%
  • (R)-(+)-2-AMino-3-benzyloxy-1-propanol, 98+%
  • (R)-2-Amino-3-(benzyloxy)propan-1-ol
  • H-Ser(Bzl)-ol.HCl
  • H-L-Ser(Bzl)-ol·HCl
  • L-Serinol(Bzl) hydrochloride
  • O-Benzyl-L-serinol hydrochloride≥ 98% (HPLC)
  • (2R)-(+)-2-Amino-3-(benzyloxy)propan-1-ol
  • 1-Propanol, 2-amino-3-(phenylmethoxy)-, (2R)-
  • (R)-2-AMINO-3-BENZYLOXY-1-PROPANOL USP/EP/BP
  • (2R)-2-amino-3-phenylmethoxypropan-1-ol
  • (<i>R</i>)-(+)-2-Amino-3-benzyloxy-1-propanol
  • Ser(bzl)-OL.HCL
  • 58577-87-0
  • C6H5CH2OCH2CHNH2CH2OH
  • Amino Alcohols
  • Chiral Building Blocks
  • Asymmetric Synthesis
  • Organic Building Blocks
  • Amino Alcohols
  • Chiral Building Blocks
  • Organic Building Blocks