ChemicalBook > CAS DataBase List > Ethylparaben

Ethylparaben

Product Name
Ethylparaben
CAS No.
120-47-8
Chemical Name
Ethylparaben
Synonyms
Ethyl;ETHYL 4-HYDROXYBENZOATE;Sobrol A;Solbrol A;ethyl butex;ETHYL PARASEPT;4-Carbethoxyphenol;ETHYL P-HYDROXYBENZOATE;Ethyl para-hydroxybenzoate;Ethyl 4-hydroxybenzoate,99%
CBNumber
CB5119772
Molecular Formula
C9H10O3
Formula Weight
166.17
MOL File
120-47-8.mol
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Ethylparaben Property

Melting point:
114-117 °C (lit.)
Boiling point:
297-298 °C (lit.)
Density 
1.1708 (rough estimate)
vapor pressure 
0.00012 hPa (25 °C)
refractive index 
1.5286 (estimate)
Flash point:
297-298°C
storage temp. 
2-8°C
solubility 
Very slightly soluble in water, freely soluble in ethanol (96 per cent) and in methanol.
form 
Crystalline Powder
pka
8.31±0.13(Predicted)
color 
White
PH
4.5-5.5 (H2O, 20°C) (saturated solution)
Odor
at 100.00?%. mild phenolic
Water Solubility 
Slightly soluble in water.
Merck 
14,3837
BRN 
1101972
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
LogP
2.470
CAS DataBase Reference
120-47-8(CAS DataBase Reference)
NIST Chemistry Reference
Ethylparaben(120-47-8)
EPA Substance Registry System
Ethylparaben (120-47-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
1
RTECS 
DH2190000
Autoignition Temperature
495 °C
TSCA 
Yes
HS Code 
29182930
Hazardous Substances Data
120-47-8(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
111988
Product name
Ethyl 4-hydroxybenzoate
Purity
ReagentPlus , 99%
Packaging
5g
Price
$21.2
Updated
2024/03/01
Sigma-Aldrich
Product number
111988
Product name
Ethyl 4-hydroxybenzoate
Purity
ReagentPlus , 99%
Packaging
100g
Price
$36.3
Updated
2024/03/01
Sigma-Aldrich
Product number
1.00887
Product name
Ethyl 4-hydroxybenzoate
Purity
EMPROVE? ESSENTIAL Ph Eur,BP,JP,NF
Packaging
5kg
Price
$453
Updated
2022/05/15
Sigma-Aldrich
Product number
1.00887
Product name
Ethyl 4-hydroxybenzoate
Purity
EMPROVE? ESSENTIAL Ph Eur,BP,JP,NF
Packaging
25kg
Price
$1508
Updated
2022/05/15
TCI Chemical
Product number
E0884
Product name
Ethyl 4-Hydroxybenzoate [for Biochemical Research]
Purity
>99.0%(GC)(T)
Packaging
5g
Price
$26
Updated
2024/03/01
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Ethylparaben Chemical Properties,Usage,Production

Chemical Properties

Ethylparaben occurs as a white, odorless or almost odorless, crystalline powder.

Uses

Ethylparaben is mainly used as antiseptics in cosmetics, food and medicine. It is also can be used as feed preservatives and antiseptic for bacteria.
Ethylparaben is a preservative that is used in the formulation of cosmetics and personal care products in order to extend the shelf-life by preventing microbial contamination. In most formulations, parabens are used at very low levels ranging from 0.01 to 0.3%.
Ethylparaben, a novel sorbent for solid-phase extraction, was used to study its retention property. It has high extraction efficiency towards the compounds tested owing to the electrostatic interaction, hydrophobic interaction and hydrogen bonding.

Definition

ChEBI: Ethylparaben is an ethyl ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with ethanol, It has a role as an antimicrobial food preservative, an antifungal agent, a plant metabolite and a phytoestrogen. It is a paraben and an ethyl ester.

Production Methods

Ethylparaben is prepared by the esterification of p-hydroxybenzoic acid with ethanol (95%).

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 3343, 1974 DOI: 10.1021/jo00937a007

Pharmaceutical Applications

Ethylparaben is widely used as an antimicrobial preservative in cosmetics,food products, and pharmaceutical formulations.
It may be used either alone or in combination with other paraben esters or with other antimicrobial agents. In cosmetics it is one of the most frequently used preservatives.
The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds.
Owing to the poor solubility of the parabens, paraben salts, particularly the sodium salt, are frequently used. However, this may cause the pH of poorly buffered formulations to become more alkaline.

Safety

Ethylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics, food products, and oral and topical pharmaceutical formulations.
Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions. Parabens, in vivo, have also been reported to exhibit estrogenic responses in fish.(10) The WHO has set an estimated total acceptable daily intake for methyl-, ethyl-, and propylparabens at up to 10 mg/kg body-weight.
LD50 (mouse, IP): 0.52 g/kg
LD50 (mouse, oral): 3.0 g/kg

storage

Aqueous ethylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition. At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature).
Ethylparaben should be stored in a well-closed container in a cool, dry place.

Incompatibilities

The antimicrobial properties of ethylparaben are considerably reduced in the presence of nonionic surfactants as a result of micellization. Absorption of ethylparaben by plastics has not been reported, although it appears probable given the behavior of other parabens. Ethylparaben is coabsorbed on silica in the presence of ethoxylated phenols. Yellow iron oxide, ultramarine blue, and aluminum silicate extensively absorb ethylparaben in simple aqueous systems, thus reducing preservative efficacy.
Ethylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.

Regulatory Status

Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral, otic, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Ethylparaben Preparation Products And Raw materials

Raw materials

4-Hydroxybenzoic acid Ethanol Trap Esterification kettle Activated carbon,decolor Sulfuric acid

Preparation Products

Propylparaben 3,5-Dichloro-4-hydroxybenzoic acid Dazoxiben Gabexate mesylate 2,6-Dichlorophenol ETHYL 4-(2-CHLOROETHOXY)BENZOATE
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Ethylparaben Suppliers

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View Lastest Price from Ethylparaben manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Ethylparaben 120-47-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0～100.5%,BP2018/USP40
Supply Ability
20Tons/month
Release date
2021-06-21
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Ethylparaben 120-47-8
Price
US $60.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-05-09
Baoji Guokang Bio-Technology Co., Ltd.
Product
Ethylparaben 120-47-8
Price
US $13.00/KG
Min. Order
50Kg/Drum
Purity
99%
Supply Ability
1000T
Release date
2021-06-03

120-47-8, EthylparabenRelated Search:

ISOXADIFEN-ETHYL Teniposide Dimethyl succinate Phenol 3-Aminophenol SODIUM ETHYLPARABEN Phenol Red Ethylparaben 2-Ethoxyethanol Ethyl formate Methyl salicylate 2-Aminophenol Methyl acrylate Methylparaben Ethanol Ethyl acetate Ethyl propionate Trinexapac-ethyl

  • 4-Carbethoxyphenol
  • nipaginaa
  • Nipazin A
  • nipazina
  • Para-hydroxybenzoic acid ethyl ester
  • p-Carbethoxyphenol
  • p-Hydroxybenzoic ethyl ester
  • p-hydroxy-benzoicaciethylester
  • p-hydroxybenzoicethylester
  • p-Oxybenzoesaeureaethylester
  • Sobrol A
  • Solbrol A
  • solbrola
  • Tegosept E
  • ETHYLPARABEN,NF
  • 4-HYDROXYBENZOICACIDETHYLESTER(ETHYLPARABEN)
  • PARABEN,ETHYL
  • Ethyl-4-hydroxybenzoat
  • Ethyl P-Hdroxybenzoate
  • ETHYLP-HYDROXYBENZOATE/EASEPTOL
  • ETHYL-4-HYDROXYBENZOATE WITH HPLC
  • ETHYLPARABEN (ETHYL 4-HYDROXYBENZOATE)
  • 4-Hydroxybenzoic acid ethyl
  • Aceptin A
  • Sorbrol A
  • Ethyl 4-hydroxybenzoate,99%
  • Ethyl p-Hydrobenzoate
  • 2-Ethyl-4-hydroxy-benzoicacid
  • Ethyl-p-hydroxybenzoate 5g [120-47-8]
  • Ethylparaben (200 mg)
  • Of ethyl
  • Of ethyl (Ethylparaben)
  • Ethyl cheMosept
  • Solbro A
  • Ethyl 4-Hydroxybenzoate [for BiocheMical Research]
  • Ethyl Paraben (EP)
  • Ethyl p-Hydroxybenzoate (Ethylparaben)
  • Ethyl 4-Hydroxybenzoate,(S)
  • ETHYL 4-HYDROXYBENZOATE / ETHYLPARABEN
  • Ethyl 4-hydroxybenzoate, 99% 100GR
  • Easeptol
  • Ester etylowykwasu p-hydroksybenzoesowego
  • esteretylowykwasup-hydroksybenzoesowego
  • ethvlparaben
  • Ethyl
  • Ethyl para-hydroxybenzoate
  • Ethyl p-oxybenzoate
  • Ethylester kyseliny p-hydroxybenzoove
  • ethylesterkyselinyp-hydroxybenzoove
  • ethylhydroxybenzoate
  • Mekkings E
  • NSC 23514
  • Ethylparaben 4-Hydroxybenzoic Acid Ethyl Ester
  • Methylparaben Impurity 1（Ethylparaben）
  • Compound sodium acetate neper gold
  • Methyldopa impurity 1
  • ETHYL 4-HYDROXYBENZOATE
  • ethyl butex