9-Aminocamptothecin

ChemicalBook > CAS DataBase List > 9-Aminocamptothecin

Product Name: 9-Aminocamptothecin
CAS No.: 91421-43-1
Chemical Name: 9-Aminocamptothecin
Synonyms: NSC-603071;1H-Pyrano(3;AMinocaMptothecin;9-AMINO-CAMPTOTHECIN;CAMPTOTHECIN, 9-AMINO-;9-Aminocamptothecin >Camptothecin Impurity 14;(20S)-9-AMINOCAMPTOTHECIN;9-Aminocamptothecin, >96%;9-amino-2(S)-camptothecin
CBNumber: CB5125434
Molecular Formula: C20H17N3O4
Formula Weight: 363.37
MOL File: 91421-43-1.mol

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9-Aminocamptothecin Property

Melting point:: 142.0-145.0 °C
Boiling point:: 819.6±65.0 °C(Predicted)
Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: ≤1mg/ml in DMSO;1mg/ml in dimethyl formamide
form: powder to crystal
pka: 11.23±0.20(Predicted)
color: Light yellow to Yellow to Orange
Merck: 14,431
InChIKey: FUXVKZWTXQUGMW-FQEVSTJZSA-N
CAS DataBase Reference: 91421-43-1(CAS DataBase Reference)

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Safety

RTECS: UQ0490500
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2063
Product name: 9-Aminocamptothecin
Purity: >95.0%(HPLC)
Packaging: 10mg
Price: $485
Updated: 2024/03/01

Cayman Chemical

Product number: 17232
Product name: 9-amino Camptothecin
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17232
Product name: 9-amino Camptothecin
Purity: ≥95%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 17232
Product name: 9-amino Camptothecin
Purity: ≥95%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 17232
Product name: 9-amino Camptothecin
Purity: ≥95%
Packaging: 25mg
Price: $381
Updated: 2024/03/01

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9-Aminocamptothecin Chemical Properties,Usage,Production

Uses

9-Amino Camptothecin is a derivative of Camptothecin (C175150), as antitumor agent.

Definition

ChEBI: 9-Aminocamptothecin is a pyranoindolizinoquinoline.

Biological Activity

9-amino camptothecin is a topoisomerase i inhibitor [1][2].dna topoisomerases relax dna torsional strain generated during replication, transcription, recombination, repair, and chromosome condensation. the relaxation of dna supercoiling by topoisomerase i is enabled by a mechanism of controlled rotation around a transient dna single-strand break. camptothecin (cpt) is isolated from the bark of the chinese tree camptotheca accuminata [3].9-amino camptothecin, a water-soluble camptothecin analogue, is a topoisomerase i inhibitor. in human ht-29 colon adenocarcinoma, 9-amino camptothecin (9-ac) exhibited cytotoxicity with ic50 value of 19 nm. 9-ac also induced dna damage in whole cells and nuclei at a concenstration of 85 nm and 21 nm, respectively [1].9-amino camptothecin had greater activity than camptothecin against human tumour xenografts, including lewis lung carcinoma and b16 melanoma. 9-ac had entered phase ii trials. in patients with advanced solid tumours, 9-amino camptothecin exhibited anti-tumor activity [1][2].

References

[1]. rothenberg, m.l. topoisomerase i inhibitors: review and update. annals of oncology 8(9), 837-855 (1997).
[2]. dancey j, eisenhauer ea. current perspectives on camptothecins in cancer treatment. br j cancer. 1996 aug;74(3):327-38.
[3]. drwal mn1, agama k, wakelin lp, et al. exploring dna topoisomerase i ligand space in search of novel anticancer agents. plos one. 2011;6(9):e25150.

9-Aminocamptothecin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 9-Aminocamptothecin manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 9-Aminocamptothecin 91421-43-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Shochem(Shanghai) Co.,Ltd

Product: 9-Aminocamptothecin 91421-43-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 95%
Supply Ability: 1kg/month
Release date: 2020-04-20

Career Henan Chemical Co

Product: 9-Aminocamptothecin 91421-43-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KGS
Release date: 2019-12-31

91421-43-1, 9-AminocamptothecinRelated Search:

10-Hydroxycamptothecin Glycine Betaine (+)-Camptothecin ALTRENOGEST 4-Ethyl-4,10-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Rubitecan 9-methoxy-7-ethylcamptothecin 7-ETHYL-10-HYDROXYCAMPTOTHECIN,98% Camptothecin 20R-Camptothecin 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4-hydroxy-9-methoxy-, (4S)- SN-38-D3 7-Ethyl-20(R)-camptothecin 9-amino-20-camptothecin Hydroxyl camptothecine AMINO ACIDS 9-Aminocamptothecin

4':6,7)indolizino(1,2-B)quinoline-3,14(4H,12H)-dione

4':6,7)indolizino(1,2-B)quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (S)-

CAMPTOTHECIN, 9-AMINO-(RG)

(S)-10-AMino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

(S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-di

CAMPTOTHECIN, 9-AMINO-

AMinocaMptothecin

9-AMINO-CAMPTOTHECIN

9-Amino-20-(S)-camptothecin

10-amino-4(s)-4-ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

(20S)-9-AMINOCAMPTOTHECIN

9-Aminocamptothecin, >96%

2-aminobenzoic acid [(2R,3S,4R,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxyphosphoryl]oxymethyl]-3-oxolanyl] ester

9-Aminocamptothecin，9-Amino-20-(S)-camptothecin

(4S)-4α-Ethyl-4,12-dihydro-4-hydroxy-10-amino-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione

9-Amino-20(S)-camptothecine

NSC-603071

(S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano(3

1H-Pyrano(3

9-Aminocamptothecin, 98%, from the fruit of Camptotheca acuminata Decne.

9-Aminocamptothecin &gt

9-amino-2(S)-camptothecin

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (4S)-

Camptothecin Impurity 14

91421-43-1

C20H17N3O4

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