ChemicalBook > CAS DataBase List > 9-Aminocamptothecin

9-Aminocamptothecin

Product Name
9-Aminocamptothecin
CAS No.
91421-43-1
Chemical Name
9-Aminocamptothecin
Synonyms
NSC-603071;1H-Pyrano(3;AMinocaMptothecin;9-AMINO-CAMPTOTHECIN;CAMPTOTHECIN, 9-AMINO-;9-Aminocamptothecin >Camptothecin Impurity 14;(20S)-9-AMINOCAMPTOTHECIN;9-Aminocamptothecin, >96%;9-amino-2(S)-camptothecin
CBNumber
CB5125434
Molecular Formula
C20H17N3O4
Formula Weight
363.37
MOL File
91421-43-1.mol
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9-Aminocamptothecin Property

Melting point:
142.0-145.0 °C
Boiling point:
819.6±65.0 °C(Predicted)
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
≤1mg/ml in DMSO;1mg/ml in dimethyl formamide
form 
powder to crystal
pka
11.23±0.20(Predicted)
color 
Light yellow to Yellow to Orange
Merck 
14,431
InChIKey
FUXVKZWTXQUGMW-FQEVSTJZSA-N
CAS DataBase Reference
91421-43-1(CAS DataBase Reference)
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Safety

RTECS 
UQ0490500
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2063
Product name
9-Aminocamptothecin
Purity
>95.0%(HPLC)
Packaging
10mg
Price
$485
Updated
2024/03/01
Cayman Chemical
Product number
17232
Product name
9-amino Camptothecin
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17232
Product name
9-amino Camptothecin
Purity
≥95%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
17232
Product name
9-amino Camptothecin
Purity
≥95%
Packaging
10mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
17232
Product name
9-amino Camptothecin
Purity
≥95%
Packaging
25mg
Price
$381
Updated
2024/03/01
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9-Aminocamptothecin Chemical Properties,Usage,Production

Uses

9-Amino Camptothecin is a derivative of Camptothecin (C175150), as antitumor agent.

Definition

ChEBI: 9-Aminocamptothecin is a pyranoindolizinoquinoline.

Biological Activity

9-amino camptothecin is a topoisomerase i inhibitor [1][2].dna topoisomerases relax dna torsional strain generated during replication, transcription, recombination, repair, and chromosome condensation. the relaxation of dna supercoiling by topoisomerase i is enabled by a mechanism of controlled rotation around a transient dna single-strand break. camptothecin (cpt) is isolated from the bark of the chinese tree camptotheca accuminata [3].9-amino camptothecin, a water-soluble camptothecin analogue, is a topoisomerase i inhibitor. in human ht-29 colon adenocarcinoma, 9-amino camptothecin (9-ac) exhibited cytotoxicity with ic50 value of 19 nm. 9-ac also induced dna damage in whole cells and nuclei at a concenstration of 85 nm and 21 nm, respectively [1].9-amino camptothecin had greater activity than camptothecin against human tumour xenografts, including lewis lung carcinoma and b16 melanoma. 9-ac had entered phase ii trials. in patients with advanced solid tumours, 9-amino camptothecin exhibited anti-tumor activity [1][2].

References

[1]. rothenberg, m.l. topoisomerase i inhibitors: review and update. annals of oncology 8(9), 837-855 (1997).
[2]. dancey j, eisenhauer ea. current perspectives on camptothecins in cancer treatment. br j cancer. 1996 aug;74(3):327-38.
[3]. drwal mn1, agama k, wakelin lp, et al. exploring dna topoisomerase i ligand space in search of novel anticancer agents. plos one. 2011;6(9):e25150.

9-Aminocamptothecin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 9-Aminocamptothecin manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
9-Aminocamptothecin 91421-43-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Shochem(Shanghai) Co.,Ltd
Product
9-Aminocamptothecin 91421-43-1
Price
US $0.00-0.00/g
Min. Order
1g
Purity
95%
Supply Ability
1kg/month
Release date
2020-04-20
Career Henan Chemical Co
Product
9-Aminocamptothecin 91421-43-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2019-12-31

91421-43-1, 9-AminocamptothecinRelated Search:

10-Hydroxycamptothecin Glycine Betaine (+)-Camptothecin ALTRENOGEST 4-Ethyl-4,10-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Rubitecan 9-methoxy-7-ethylcamptothecin 7-ETHYL-10-HYDROXYCAMPTOTHECIN,98% Camptothecin 20R-Camptothecin 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4-hydroxy-9-methoxy-, (4S)- SN-38-D3 7-Ethyl-20(R)-camptothecin 9-amino-20-camptothecin Hydroxyl camptothecine AMINO ACIDS 9-Aminocamptothecin

  • 4':6,7)indolizino(1,2-B)quinoline-3,14(4H,12H)-dione
  • 4':6,7)indolizino(1,2-B)quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (S)-
  • CAMPTOTHECIN, 9-AMINO-(RG)
  • (S)-10-AMino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • (S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-di
  • CAMPTOTHECIN, 9-AMINO-
  • AMinocaMptothecin
  • 9-AMINO-CAMPTOTHECIN
  • 9-Amino-20-(S)-camptothecin
  • 10-amino-4(s)-4-ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
  • (20S)-9-AMINOCAMPTOTHECIN
  • 9-Aminocamptothecin, >96%
  • 2-aminobenzoic acid [(2R,3S,4R,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxyphosphoryl]oxymethyl]-3-oxolanyl] ester
  • 9-Aminocamptothecin，9-Amino-20-(S)-camptothecin
  • (4S)-4α-Ethyl-4,12-dihydro-4-hydroxy-10-amino-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
  • 9-Amino-20(S)-camptothecine
  • NSC-603071
  • (S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano(3
  • 1H-Pyrano(3
  • 9-Aminocamptothecin, 98%, from the fruit of Camptotheca acuminata Decne.
  • 9-Aminocamptothecin &gt
  • 9-amino-2(S)-camptothecin
  • 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (4S)-
  • Camptothecin Impurity 14
  • 91421-43-1
  • C20H17N3O4
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