9-Aminocamptothecin
- Product Name
- 9-Aminocamptothecin
- CAS No.
- 91421-43-1
- Chemical Name
- 9-Aminocamptothecin
- Synonyms
- NSC-603071;1H-Pyrano(3;AMinocaMptothecin;9-AMINO-CAMPTOTHECIN;CAMPTOTHECIN, 9-AMINO-;9-Aminocamptothecin >Camptothecin Impurity 14;(20S)-9-AMINOCAMPTOTHECIN;9-Aminocamptothecin, >96%;9-amino-2(S)-camptothecin
- CBNumber
- CB5125434
- Molecular Formula
- C20H17N3O4
- Formula Weight
- 363.37
- MOL File
- 91421-43-1.mol
9-Aminocamptothecin Property
- Melting point:
- 142.0-145.0 °C
- Boiling point:
- 819.6±65.0 °C(Predicted)
- Density
- 1.55±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- ≤1mg/ml in DMSO;1mg/ml in dimethyl formamide
- form
- powder to crystal
- pka
- 11.23±0.20(Predicted)
- color
- Light yellow to Yellow to Orange
- Merck
- 14,431
- InChIKey
- FUXVKZWTXQUGMW-FQEVSTJZSA-N
- CAS DataBase Reference
- 91421-43-1(CAS DataBase Reference)
Safety
- RTECS
- UQ0490500
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A2063
- Product name
- 9-Aminocamptothecin
- Purity
- >95.0%(HPLC)
- Packaging
- 10mg
- Price
- $485
- Updated
- 2024/03/01
- Product number
- 17232
- Product name
- 9-amino Camptothecin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17232
- Product name
- 9-amino Camptothecin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 17232
- Product name
- 9-amino Camptothecin
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 17232
- Product name
- 9-amino Camptothecin
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $381
- Updated
- 2024/03/01
9-Aminocamptothecin Chemical Properties,Usage,Production
Uses
9-Amino Camptothecin is a derivative of Camptothecin (C175150), as antitumor agent.
Definition
ChEBI: 9-Aminocamptothecin is a pyranoindolizinoquinoline.
Biological Activity
9-amino camptothecin is a topoisomerase i inhibitor [1][2].dna topoisomerases relax dna torsional strain generated during replication, transcription, recombination, repair, and chromosome condensation. the relaxation of dna supercoiling by topoisomerase i is enabled by a mechanism of controlled rotation around a transient dna single-strand break. camptothecin (cpt) is isolated from the bark of the chinese tree camptotheca accuminata [3].9-amino camptothecin, a water-soluble camptothecin analogue, is a topoisomerase i inhibitor. in human ht-29 colon adenocarcinoma, 9-amino camptothecin (9-ac) exhibited cytotoxicity with ic50 value of 19 nm. 9-ac also induced dna damage in whole cells and nuclei at a concenstration of 85 nm and 21 nm, respectively [1].9-amino camptothecin had greater activity than camptothecin against human tumour xenografts, including lewis lung carcinoma and b16 melanoma. 9-ac had entered phase ii trials. in patients with advanced solid tumours, 9-amino camptothecin exhibited anti-tumor activity [1][2].
References
[1]. rothenberg, m.l. topoisomerase i inhibitors: review and update. annals of oncology 8(9), 837-855 (1997).
[2]. dancey j, eisenhauer ea. current perspectives on camptothecins in cancer treatment. br j cancer. 1996 aug;74(3):327-38.
[3]. drwal mn1, agama k, wakelin lp, et al. exploring dna topoisomerase i ligand space in search of novel anticancer agents. plos one. 2011;6(9):e25150.
9-Aminocamptothecin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 9-Aminocamptothecin manufacturers
- Product
- 9-Aminocamptothecin 91421-43-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- 9-Aminocamptothecin 91421-43-1
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 95%
- Supply Ability
- 1kg/month
- Release date
- 2020-04-20
- Product
- 9-Aminocamptothecin 91421-43-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2019-12-31