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9-Aminocamptothecin

Product Name
9-Aminocamptothecin
CAS No.
91421-43-1
Chemical Name
9-Aminocamptothecin
Synonyms
NSC-603071;1H-Pyrano(3;AMinocaMptothecin;9-AMINO-CAMPTOTHECIN;CAMPTOTHECIN, 9-AMINO-;9-Aminocamptothecin >Camptothecin Impurity 14;(20S)-9-AMINOCAMPTOTHECIN;9-Aminocamptothecin, >96%;9-amino-2(S)-camptothecin
CBNumber
CB5125434
Molecular Formula
C20H17N3O4
Formula Weight
363.37
MOL File
91421-43-1.mol
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9-Aminocamptothecin Property

Melting point:
142.0-145.0 °C
Boiling point:
819.6±65.0 °C(Predicted)
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
≤1mg/ml in DMSO;1mg/ml in dimethyl formamide
form 
powder to crystal
pka
11.23±0.20(Predicted)
color 
Light yellow to Yellow to Orange
Merck 
14,431
InChIKey
FUXVKZWTXQUGMW-FQEVSTJZSA-N
CAS DataBase Reference
91421-43-1(CAS DataBase Reference)
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Safety

RTECS 
UQ0490500
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2063
Product name
9-Aminocamptothecin
Purity
>95.0%(HPLC)
Packaging
10mg
Price
$485
Updated
2024/03/01
Cayman Chemical
Product number
17232
Product name
9-amino Camptothecin
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17232
Product name
9-amino Camptothecin
Purity
≥95%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
17232
Product name
9-amino Camptothecin
Purity
≥95%
Packaging
10mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
17232
Product name
9-amino Camptothecin
Purity
≥95%
Packaging
25mg
Price
$381
Updated
2024/03/01
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9-Aminocamptothecin Chemical Properties,Usage,Production

Uses

9-Amino Camptothecin is a derivative of Camptothecin (C175150), as antitumor agent.

Definition

ChEBI: 9-Aminocamptothecin is a pyranoindolizinoquinoline.

Biological Activity

9-amino camptothecin is a topoisomerase i inhibitor [1][2].dna topoisomerases relax dna torsional strain generated during replication, transcription, recombination, repair, and chromosome condensation. the relaxation of dna supercoiling by topoisomerase i is enabled by a mechanism of controlled rotation around a transient dna single-strand break. camptothecin (cpt) is isolated from the bark of the chinese tree camptotheca accuminata [3].9-amino camptothecin, a water-soluble camptothecin analogue, is a topoisomerase i inhibitor. in human ht-29 colon adenocarcinoma, 9-amino camptothecin (9-ac) exhibited cytotoxicity with ic50 value of 19 nm. 9-ac also induced dna damage in whole cells and nuclei at a concenstration of 85 nm and 21 nm, respectively [1].9-amino camptothecin had greater activity than camptothecin against human tumour xenografts, including lewis lung carcinoma and b16 melanoma. 9-ac had entered phase ii trials. in patients with advanced solid tumours, 9-amino camptothecin exhibited anti-tumor activity [1][2].

References

[1]. rothenberg, m.l. topoisomerase i inhibitors: review and update. annals of oncology 8(9), 837-855 (1997).
[2]. dancey j, eisenhauer ea. current perspectives on camptothecins in cancer treatment. br j cancer. 1996 aug;74(3):327-38.
[3]. drwal mn1, agama k, wakelin lp, et al. exploring dna topoisomerase i ligand space in search of novel anticancer agents. plos one. 2011;6(9):e25150.

9-Aminocamptothecin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 9-Aminocamptothecin manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
9-Aminocamptothecin 91421-43-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Shochem(Shanghai) Co.,Ltd
Product
9-Aminocamptothecin 91421-43-1
Price
US $0.00-0.00/g
Min. Order
1g
Purity
95%
Supply Ability
1kg/month
Release date
2020-04-20
Career Henan Chemical Co
Product
9-Aminocamptothecin 91421-43-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2019-12-31

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