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DPQ

Product Name
DPQ
CAS No.
129075-73-6
Chemical Name
DPQ
Synonyms
DPQ;DMEM(Low Glucose);PARP Inhibitor III, DPQ;PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem;3,4-DIHYDRO-5[4-(1-PIPERINDINYL)BUTOXY]-1(2H)-ISOQUINOLINE;3,4-DIHYDRO-5[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINE;5-(4-piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one;3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXY]-1(2H)-ISOQUINOLINONE;3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINONE;1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-
CBNumber
CB5126204
Molecular Formula
C18H26N2O2
Formula Weight
302.41
MOL File
129075-73-6.mol
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DPQ Property

Melting point:
107-109°
Boiling point:
528.8±50.0 °C(Predicted)
Density 
1.096±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: Soluble
form 
solid
pka
14.54±0.20(Predicted)
color 
White to off-white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D5314
Product name
DPQ
Purity
≥98% (HPLC), solid
Packaging
1mg
Price
$130
Updated
2024/03/01
Sigma-Aldrich
Product number
300270
Product name
PARP Inhibitor III, DPQ
Packaging
1mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
14450
Product name
DPQ
Purity
≥99%
Packaging
1mg
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
14450
Product name
DPQ
Purity
≥99%
Packaging
5mg
Price
$201
Updated
2024/03/01
Sigma-Aldrich
Product number
D5314
Product name
DPQ
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$443
Updated
2024/03/01
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DPQ Chemical Properties,Usage,Production

Description

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. DPQ is a potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM. It is approximately 10-fold less potent against PARP2. DPQ can be used in either cells or in animals.

Uses

DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.

Uses

3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone is a potent inhibitor of poly(ADP-ribose) polymerases, a family of enzymes that plays a crucial role in DNA repair and apoptosis in respons e to reactive oxygen and nitrogen species.

Uses

Reagent for inhibition of PARP.

Biochem/physiol Actions

3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.

storage

+4°C

DPQ Preparation Products And Raw materials

Raw materials

Preparation Products

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DPQ Suppliers

Canada 1 CHINA 88 India 1 Switzerland 3 United Kingdom 2 United States 10 Global 105

129075-73-6, DPQRelated Search:

4-AMINO-1,8-NAPHTHALIMIDE 3-Aminobenzamide NU1025 DMEM/F12 medium DMEM medium 4-Hydroxyquinazoline Rucaparib ABT-888 1,5-ISOQUINOLINEDIOL 1(2H)-Isoquinolinone, 5-aMino-, Monohydrochloride 5-Benzoyloxy-1(2H)-isoquinolinone 3-(4-CHLORO-PHENYL)-QUINOXALINE-5-CARBOXYLIC ACID AMIDE TIQ-A 5-METHOXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE DPQ 5-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 1,2,3,4-TETRAHYDRO-ISOQUINOLIN-5-OL DULBECCO'S MODIFIED EAGLE'S MEDIUM W/L-&

  • PARP Inhibitor III, DPQ
  • 5-(4-piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one
  • DPQ
  • 3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXY]-1(2H)-ISOQUINOLINONE
  • 3,4-DIHYDRO-5[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINE
  • 3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINONE
  • 3,4-DIHYDRO-5[4-(1-PIPERINDINYL)BUTOXY]-1(2H)-ISOQUINOLINE
  • 5-[4-(1-PIPERIDINYL)-BUTYLOXY]-1,2,3,4-TETRAHYDROISOQUINOLIN-1-ONE
  • PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem
  • 1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-
  • DMEM(Low Glucose)
  • 129075-73-6
  • BioChemical
  • Apoptosis and Cell Cycle
  • Cell Biology
  • Cell Signaling and Neuroscience
  • PARP Regulators
  • PARP