ChemicalBook > CAS DataBase List > 2-Phenoxyethylbromide

2-Phenoxyethylbromide

Product Name: 2-Phenoxyethylbromide
CAS No.: 589-10-6
Chemical Name: 2-Phenoxyethylbromide
Synonyms: NSC 8055;AKOS BC-2647;-Bromophenetole;Beta-broMoether;á-bromophenetole;B-BROMOPHENETOLE;β-Bromophenetole;AKOS BBS-00006631;BETA-BROMOPHENETOL;PHENOXYETHYLBROMIDE
CBNumber: CB5129104
Molecular Formula: C8H9BrO
Formula Weight: 201.06
MOL File: 589-10-6.mol

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2-Phenoxyethylbromide Property

Melting point:: 31-34 °C(lit.)
Boiling point:: 144 °C40 mm Hg(lit.)
Density: 1.45
refractive index: 1.555-1.557
Flash point:: 150 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Solubility in methanol is almost transparent. Soluble in chloroform and ethyl acetate.
form: Liquid After Melting
color: Clear colorless
Water Solubility: Insoluble in water.
BRN: 508290
CAS DataBase Reference: 589-10-6(CAS DataBase Reference)
NIST Chemistry Reference: Benzene, (2-bromoethoxy)-(589-10-6)
EPA Substance Registry System: Benzene, (2-bromoethoxy)- (589-10-6)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 23-24/25-26
RIDADR: 1325
WGK Germany: 3
Hazard Note: Irritant
TSCA: Yes
HazardClass: 4.1
PackingGroup: II
HS Code: 29093038

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B75506
Product name: β-Bromophenetole
Purity: 98%
Packaging: 100g
Price: $260
Updated: 2025/07/31

Sigma-Aldrich

Product number: B75506
Product name: β-Bromophenetole
Purity: 98%
Packaging: 25g
Price: $109
Updated: 2023/06/20

TCI Chemical

Product number: B0931
Product name: beta-Bromophenetole
Purity: >97.0%(GC)
Packaging: 25g
Price: $86
Updated: 2025/07/31

Usbiological

Product number: 286616
Product name: 2-Phenoxyethylbromide
Packaging: 25g
Price: $305
Updated: 2021/12/16

TRC

Product number: B686385
Product name: 1-Bromo-2-phenoxyethane
Packaging: 250g
Price: $230
Updated: 2021/12/16

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2-Phenoxyethylbromide Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

2-Phenoxyethyl bromide is used in the synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones.

Application

2-Phenoxyethyl bromide can be used as a pharmaceutical intermediate for the synthesis of nafazodone and oxiperomide.

Preparation

2-Phenoxyethyl bromide is synthesized by the reaction of phenol and dibromoethane. Put phenol, dibromoethane and sodium hydroxide in a reaction pot and stir and mix, react at 110 °C for 6 hours, recover dibromoethane, the recovery amount is about 60%, wash with 5% sodium hydroxide solution and water, and divide Take the oil layer, distill under reduced pressure, and collect the fractions at 130-150°C (6.7kPa) to obtain (2-bromoethoxy)benzene.

Synthesis

106-93-4

108-95-2

589-10-6

The general procedure for the synthesis of 2-phenoxyethyl bromide from phenol and 1,2-dibromoethane was as follows: phenol (10 mmol), 1,2-dibromoethane (50 mmol) and anhydrous potassium carbonate (30 mmol) were suspended in anhydrous acetonitrile (50 mL) under nitrogen protection. The reaction mixture was stirred at 80 °C for 6 hours. Upon completion of the reaction, the mixture was filtered to recover potassium carbonate, which could be dried under vacuum at 120 °C for 5 h to reactivate. The filtrate was concentrated under reduced pressure to remove the solvent and the resulting crude product was purified by silica gel column chromatography using petroleum ether as eluent to give the target compound 2-phenoxyethyl bromide (Scheme 1, Table 4, Entry 1). The product was a solid with a melting point of 33-34 °C. Its structure was confirmed by 1H NMR (400 MHz, CDCl3), 13C NMR (100 MHz, CDCl3) and mass spectrometry (MS).1H NMR data: δ 7.29-7.26 (m, 2H), 6.95-6.92 (m, 3H), 4.26-4.23 (t, J = 3.6 Hz, 2H), 3.61- 3.58 (t, J = 3.6 Hz, 2H).13C NMR data: δ 158, 129.5, 121.4, 114.8, 67.8, 29.1. Mass spectrometry data: m/z 202 (50, M+2), 200 (48, M+), 109 (97), 107 (100), 94 (60), 77 (29), 65 (38), 51 (22), 39 (52).

References

[1] Journal of Chemistry, 2017, vol. 2017,
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 3, p. 1244 - 1251
[3] Patent: US4474964, 1984, A
[4] Patent: US4533731, 1985, A
[5] Russian Journal of Organic Chemistry, 2009, vol. 45, # 5, p. 681 - 686

2-Phenoxyethylbromide Preparation Products And Raw materials

Raw materials

CHLOROPICRIN & ETHYLENE DIBROMIDE Phenetole

Preparation Products

2-Phenoxyethylamine

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View Lastest Price from 2-Phenoxyethylbromide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Phenoxyethylbromide 589-10-6
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-20

Career Henan Chemical Co

Product: 2-Phenoxyethylbromide 589-10-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-09

589-10-6, 2-PhenoxyethylbromideRelated Search:

2-Phenoxyethanol Glycidyl phenyl ether Tamoxifen Triton X-100 PHENYL VALERATE Ethopabate Dimethyl ether Phenoxyacetic acid Phenoxybenzamine hydrochloride Ethyl 2-(4-phenoxyphenoxy)ethylcarbamate Tetrabromobisphenol A bis(dibromopropyl ether) 1-Bromo-2-methoxyethane Ethylbenzene PETROLEUM ETHER 2-Butoxyethanol Decabromodiphenyl oxide Allyl phenoxyacetate 2-(2-Bromoethoxy)anisole

(2-bromoethoxy)-benzen

Benzene,(2-bromoethoxy)-

-Bromophenetole

Phenetole, beta-bromo-

PHENOXYETHYLBROMIDE

(2-BROMOETHOXY)BENZENE

2-BROMOETHYL PHENYL ETHER

(2-BROMETHOXY)BENZENE

2-PHENOXYETHYL BROMIDE

1-(2-BROMOETHOXY)BENZENE

1-BROMO-2-PHENOXYETHANE

AKOS BBS-00006631

AKOS BC-2647

BETA-PHENOXYETHYL BROMIDE

BETA-BROMOPHENETOL

BETA-BROMOPHENETOLE

2-Phenoxyethylbromide Synonyms 2-Bromoethyl phenyl ether

(2-Bromethoxy)benzene for synthesis

Domiphen Impurity 1

beta-Bromoethyl phenyl ether

á-bromophenetole

2-bromophenyl ethyl ether

2-Phenoxyethyl bromide 98%

2-Phenoxyethylbromide,98%

NSC 8055

2-Bromoethyl Phenyl Ether 2-Phenoxyethyl Bromide

Phenyl(2-bromoethyl) ether

beta-Bromophenetole,98%

(2-BROMETHOXY)BENZENE 97+%

1-Phenoxy-2-bromoethane

BETA-BROMOPHENYLETHYL ETHER

B-PHENOXYETHYL BROMIDE

B-BROMOETHYL PHENYL ETHER

B-BROMOPHENETOLE

Beta-broMoether

BetabroMobenzeneether

2-BroMoethyl Phenyl Ether, 97+%

(2-Bromoethoxy)benzene, 2-Bromoethyl phenyl ether

β-Bromophenetole &gt

β-Bromophenetole

Tamsulosin Impurity 24

FMOC-BETA-HOMOGLU(OTBU)-OH, >=98.0%

589-10-6

509-10-6

C6H5OCH2CH2Br

BrC2H4OC6H5

C6H5OCH22Br

HALOGEN

Oxygen Compounds

Organic Building Blocks

Ethers

Building Blocks

Aromatic Ethers

Phenetole

Aromatics Compounds

Anisoles, Alkyloxy Compounds & Phenylacetates

Bromine Compounds

Aromatics