dendrobine

Product Name: dendrobine
CAS No.: 2115-91-5
Chemical Name: dendrobine
Synonyms: dendrobine;Dendrobine 1%;(-)-Dendrobine;Dendrobine 20%;12-Oxodendrobane;Dendroban-12-one;Dendrobine 2115-91-5;From Dendrobium nobile;Dendrobine, 10 mM in DMSO;Dendrobine Dendroban-12-one
CBNumber: CB51331533
Molecular Formula: C16H25NO2
Formula Weight: 263.38
MOL File: 2115-91-5.mol

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dendrobine Property

Melting point:: 135-136℃
Boiling point:: 375℃
Density: 1.101
Flash point:: 133℃
storage temp.: 4°C, protect from light
solubility: ≥60mg/ml in MeOH
form: Powder
pka: 9.49±0.60(Predicted)
color: White to yellow
InChI: InChI=1S/C16H25NO2/c1-8(2)11-12-10-6-5-9-7-17(4)14(16(9,10)3)13(11)19-15(12)18/h8-14H,5-7H2,1-4H3/t9-,10+,11+,12-,13-,14-,16+/m1/s1
InChIKey: RYAHJFGVOCZDEI-UFFNCVEVSA-N
SMILES: N1(C)[C@@]2([H])[C@]3(C)[C@@]([H])(CC[C@]3([H])C1)[C@@]1([H])C(=O)O[C@]2([H])[C@H]1C(C)C

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Safety

HS Code: 29399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26067
Product name: Dendrobine
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 26067
Product name: Dendrobine
Packaging: 50mg
Price: $723
Updated: 2024/03/01

Cayman Chemical

Product number: 26067
Product name: Dendrobine
Packaging: 10mg
Price: $187
Updated: 2024/03/01

Cayman Chemical

Product number: 26067
Product name: Dendrobine
Packaging: 25mg
Price: $414
Updated: 2024/03/01

TRC

Product number: D231445
Product name: Dendrobine
Packaging: 10mg
Price: $150
Updated: 2021/12/16

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dendrobine Chemical Properties,Usage,Production

Description

Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity. It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 μg/ml. It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 μg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin at 10 μg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin.

Chemical Properties

It is easily soluble in ether and chloroform, but hardly soluble in ethanol and water. It is an active ingredient extracted from Dendrobium and its bark.

Uses

Dendrobine is an alkaloid isolated from Dendrobium nobile and is an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord.

Definition

ChEBI: Dendrobine is a member of indoles.

in vivo

Dendrobine (25 mg/kg, ip for 14 days) exhibits antitumor efficacy in A549 xenograft mouse models^[2].
Dendrobine (20 mg/kg, po for 20 days) ameliorates gestational diabetes mellitus (GDM) in mouse models^[5].

Animal Model:	A549 xenograft BALB/c mouse models^[2]
Dosage:	25 mg/kg
Administration:	ip for 14 days
Result:	Inhibited tumor growth.

Animal Model:	GDM mouse models^[5]
Dosage:	20 mg/kg
Administration:	po for 20 days
Result:	Improved glucose and insulin tolerance, reduced Th17 cells in the spleen of GDM mice.

References

[1] CHUN-WANG MENG. Picrotoxane sesquiterpenoids from the stems of Dendrobium nobile and their absolute configurations and angiogenesis effect[J]. Fitoterapia, 2017, 121: Pages 206-211. DOI: 10.1016/j.fitote.2017.07.017
[2] TIAN-HE SONG . Dendrobine targeting JNK stress signaling to sensitize chemotoxicity of cisplatin against non-small cell lung cancer cells in vitro and in vivo[J]. Phytomedicine, 2019, 53: Pages 18-27. DOI: 10.1016/j.phymed.2018.06.018

dendrobine Preparation Products And Raw materials

Raw materials

Preparation Products

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dendrobine Suppliers

China 205 United Kingdom 1 United States 12 Global 218

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
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Shanghai Moqi Biological Technology Co., LTD

Tel: 021-38218169 13681877033
Email: 2702713455@qq.com
Country: China
ProdList: 9997
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Jiangsu Yongjian Pharmaceutical Technology Co., Ltd

Tel: 17701422015
Email: 3582572959@qq.com
Country: China
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Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
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Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
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China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
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Shandong Xiya Chemical Co., Ltd

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Fax: 0539-6365991
Email: 3007715519@qq.com
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Sichuan Kulinan Technology Co., Ltd

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Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
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Shenzhen Sungening Bio-Tech Co., Ltd

Tel: +86-0755-89668383
Fax: +86-0755-89594066/4038
Email: sales@sungening.com
Country: China
ProdList: 1319
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
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View Lastest Price from dendrobine manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Dendrobine 2115-91-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-01-09

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Dendrobine 2115-91-5 2115-91-5
Price: US $89.00/mg
Min. Order: 20mg
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-16

Career Henan Chemical Co

Product: dendrobine 2115-91-5
Price: US $15.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000KG
Release date: 2018-07-26

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Dendroban-12-one

12-Oxodendrobane

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Dendrobine Dendroban-12-one

Dendrobine 1%

Dendrobine, 98%, from Dendrobium nobile Lindl

Dendrobine 2115-91-5

From Dendrobium nobile

(-)-Dendrobine

(2aS,2a1R,4aS,5R,8R,8aS,9S)-9-isopropyl-1,2a1-dimethyloctahydro-1H-7-oxa-1-aza-5,8-methanocyclopenta[cd]azulen-6(2a1H)-one

(2aS,2a1R,4aS,5R,8R,8aS,9S)-9-Isopropyl-2a1,4-dimethyldecahydro-7H-6-oxa-4-aza-5,8-methanocyclopenta[cd]azulen-7-one

Dendrobine, 10 mM in DMSO

Dendrobine 20%

dendrobine

2115-91-5

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract