ChemicalBook > CAS DataBase List > LACTACYSTIN
LACTACYSTIN
- Product Name
- LACTACYSTIN
- CAS No.
- 133343-34-7
- Chemical Name
- LACTACYSTIN
- Synonyms
- Lacta;Aids008388;LACTACYSTIN;Aids-008388;(+)-LACTACYSTIN;LACTACYSTIN (NATIVE);LACTACYSTIN USP/EP/BP;LACTACYSTIN, SYNTHETIC;LACTACYSTIN, STREPTOMYCES SP;S-[2R,3S,4R]-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYROLIDINECARBONYL
- CBNumber
- CB5136696
- Molecular Formula
- C15H24N2O7S
- Formula Weight
- 376.43
- MOL File
- 133343-34-7.mol
More
Less
LACTACYSTIN Property
- Melting point:
- 233-235°C dec.
- Boiling point:
- 714.9±60.0 °C(Predicted)
- Density
- 1.367±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 20 mg/ml), in Water (up to 10 mg/ml), or in Ethanol (up to 1 mg/ml).
- pka
- 3.11±0.10(Predicted)
- form
- powder
- color
- White to off-white
- Water Solubility
- Soluble to 10 mM in water
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. Solutions in water are not stable and must be used with one working day. Aqueous solutions should not be stored.
More
Less
Safety
- WGK Germany
- 3
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- L6785
- Product name
- Lactacystin
- Purity
- ≥90% (HPLC)
- Packaging
- 0.2mg
- Price
- $462
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 70980
- Product name
- Lactacystin
- Purity
- ≥98%
- Packaging
- 50μg
- Price
- $44
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 70980
- Product name
- Lactacystin
- Purity
- ≥98%
- Packaging
- 100μg
- Price
- $75
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 70980
- Product name
- Lactacystin
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $308
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 70980
- Product name
- Lactacystin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $570
- Updated
- 2024/03/01
More
Less
LACTACYSTIN Chemical Properties,Usage,Production
Description
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Lactacystin was first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. At concentrations from 2 to 10 μM, lactacystin induces the outgrowth of neurites in the neuroblastoma cell line Neuro2a. Lactacystin irreversibly alkylates subunit X of the 20S proteasome. The concomitant inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of lactacystin are pleiotropic and depend substantially on the expression pattern of signalling proteins within the treated cell.
Chemical Properties
White Powder
Uses
A selective and potent inhibitor of proteasome-mediated degradation of ubiquitin-tagged proteins. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP: multicatalytic proteinase complex)
Uses
Lactacystin has been used:
- as a proteasome inhibitor to inhibit protein degradation
- to inhibit proteasomal activity of cells for live cell imaging
- to block proteasomal proteolysis in human monocyte-derived dendritic cells (MoDCs) for 24 h
- to provide unilateral injection to animals to induce nigrostriatal lesions
Definition
ChEBI: L-Cysteine substituted at nitrogen by an acetyl group and at sulfur by a substituted-lactam carbonyl group.
General Description
Lactacystin is an antibiotic?and a metabolite of Streptomyces?spp.
Biochem/physiol Actions
Lactacystin can block the development of cell cycle and stimulate differentiation in a murine neuroblastoma cell line. It can serve as a precursor for?clasto-lactacystin β-lactone. Cell-permeable and irreversible proteasome inhibitor (Ki = 4nM). Inhibits NF-kB activation (IC50 = 10mM). Induces neurite outgrowth in neuro2A mouse neuroblastoma cells.
target
GABA Receptor | HDAC | NF-kB | p65 | Caspase
storage
+4°C
References
1) Omura et al. (1991), Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells; J. Antibiot., 44 113 2) Fenteany et al. (1995), Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin; Science, 268 726
LACTACYSTIN Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
LACTACYSTIN Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- +86 (531) 88811783
- Fax
- +86 (531) 55696010 QQ 1762738062
- sales@trio-pharmatech.com (International market)
- Country
- China
- ProdList
- 1856
- Advantage
- 62
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4647
- Advantage
- 58
- Tel
- 021-51320588
- Fax
- 0086-21-51320502
- tauto@tautobiotech.com
- Country
- China
- ProdList
- 3989
- Advantage
- 66
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4428
- Advantage
- 55
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3421
- Advantage
- 58
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51471
- Advantage
- 80
- Tel
- 18607101326 15172504745
- Fax
- +86-27-84254680
- aileen@chemfaces.com
- Country
- China
- ProdList
- 7059
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9709
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27322
- Advantage
- 60
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Country
- China
- ProdList
- 55827
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 28965
- Advantage
- 58
- Tel
- 18871490254
- Fax
- 027-59599243
- linda@hubeijusheng.com
- Country
- CHINA
- ProdList
- 28180
- Advantage
- 58
- Tel
- +86-0371-86658258 15093356674;
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29826
- Advantage
- 58
- Tel
- 28-85433893
- info@biocrick.com
- Country
- CHINA
- ProdList
- 4988
- Advantage
- 58
- Tel
- 17269768198
- Fax
- QQ:1213744847
- prochemx@163.com
- Country
- China
- ProdList
- 613
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44894
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8141
- Advantage
- 58
- Tel
- 18642120371
- 2837458851@qq.com
- Country
- China
- ProdList
- 9925
- Advantage
- 58
- Tel
- +86-02787215551 +86-19945035818
- Fax
- 027-87215551
- 2936752263@qq.com
- Country
- China
- ProdList
- 7954
- Advantage
- 58
- Tel
- 021-50967598 02150967598
- sales@abmole.cn
- Country
- China
- ProdList
- 4495
- Advantage
- 58
- Tel
- 021-61109150
- Fax
- 021-61105897
- sales@tcisct.com
- Country
- China
- ProdList
- 31163
- Advantage
- 58
- Tel
- 0371-0371-55153829 18003835034
- Fax
- 18003835034（微信）
- 2853979819@qq.com
- Country
- China
- ProdList
- 8648
- Advantage
- 58
- Tel
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29778
- Advantage
- 58
- Tel
- 0513-68819626; 13813788405
- Fax
- 0513-68669626
- feiyubio2@163.com
- Country
- China
- ProdList
- 4821
- Advantage
- 58
- Tel
- 15071299552
- Fax
- QQ:262933239
- 262933239@qq.com
- Country
- China
- ProdList
- 6637
- Advantage
- 58
- Tel
- +86-027-59232304 15387063101
- 2881924050@qq.com
- Country
- China
- ProdList
- 9991
- Advantage
- 58
- Tel
- 0571-87213919 17306812703
- 3007955328@qq.com
- Country
- China
- ProdList
- 5950
- Advantage
- 58
- Tel
- 18171815831
- 1341138380@qq.com
- Country
- China
- ProdList
- 2769
- Advantage
- 58
- Tel
- 17837010661
- 2224986086@qq.com
- Country
- China
- ProdList
- 4570
- Advantage
- 58
- Tel
- 021-34675735 19147740836
- 1986399151@qq.com
- Country
- China
- ProdList
- 9849
- Advantage
- 58
- Tel
- 025-58851786 17714337195
- sales@tybiochem.com
- Country
- China
- ProdList
- 4257
- Advantage
- 58
- Tel
- 021-59555769 13524932310
- Fax
- 021-50342869
- 1405894150@qq.com
- Country
- China
- ProdList
- 8221
- Advantage
- 58
- Tel
- 17721492509
- 643638326@qq.com
- Country
- China
- ProdList
- 5347
- Advantage
- 58
- Tel
- 18601717983
- guojing@bioleaper.com
- Country
- China
- ProdList
- 5615
- Advantage
- 58
- Tel
- 020-82000279 18988968278
- info@ubiochem.com
- Country
- China
- ProdList
- 9146
- Advantage
- 58
- Tel
- 029-86107037 13289246953
- info@konochemical.com
- Country
- China
- ProdList
- 2995
- Advantage
- 58
- Tel
- +undefined18621343501
- product@acmec-e.com
- Country
- China
- ProdList
- 33349
- Advantage
- 58
- Tel
- +8618327326525
- masar@topule.com
- Country
- China
- ProdList
- 8474
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6846
- Advantage
- 58
- Tel
- --
- Fax
- --
- 596799915@QQ.COM
- Country
- CHINA
- ProdList
- 2905
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6661
- Advantage
- 58
- Tel
- --
- Fax
- --
- service@neobioscience.com
- Country
- CHINA
- ProdList
- 6164
- Advantage
- 58
- Tel
- --
- Fax
- --
- hedyl@stressmarq.com
- Country
- CHINA
- ProdList
- 110
- Advantage
- 58
- Tel
- --
- Fax
- --
- yiji01@foxmail.com
- Country
- China
- ProdList
- 6294
- Advantage
- 50
- Tel
- --
- Fax
- --
- tech@chinabiovision.com
- Country
- CHINA
- ProdList
- 2731
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@qwbio.com
- Country
- China
- ProdList
- 6912
- Advantage
- 50
More
Less
View Lastest Price from LACTACYSTIN manufacturers
Career Henan Chemical Co
- Product
- lactacystin 133343-34-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10
133343-34-7, LACTACYSTINRelated Search:
CLASTO-LACTACYSTIN,Clasto-lactacystin -Lactone, Omuralide,Clasto-lactacystin b-Lactone, Omuralide,CLASTO-LACTACYSTIN B-LACTONE
MG-132
(+)-LACTACYSTIN ALLYL ESTER,LACTACYSTIN ALLYL ESTER
MG-115
N-PROPYL 3-MERCAPTOPROPIONATE
3,3'-THIODIPROPANOL
S-Butyl-D-cysteine
dacisteine
(S)-4-Hydroxy-2-pyrrolidinone
Fudosteine
S-Methyl 2-methylthiobutyrate
LACTACYSTIN
L-Cysteine
N-ACETYL-S-(3-HYDROXYPROPYL)CYSTEINE
5,5-Dimethyl-2-pyrrolidinone
clasto-lactacystin β-lactone,LACTACYSTIN, CLASTO-, BETA-LACTONE,CLASTO-LACTACYSTIN BETA-LACTONE
S-METHYL 4-METHYLPENTANETHIOATE
5-HYDROXYMETHYL-3-METHYLPYRROLIDIN-2-ONE