Loxoprofen sodium

Product Name: Loxoprofen sodium
CAS No.: 80382-23-6
Chemical Name: Loxoprofen sodium
Synonyms: Loxoprofen sodiuM hydrate;LOXOPROFEN NA;LXP;Loxonin;loxoprofern sodium;Loxoprofen Sodium impurity;cs-600;Unastin;Dipyridame;LOXOPROFEN SODIUM
CBNumber: CB5138100
Molecular Formula: C15H19NaO3
Formula Weight: 270.3
MOL File: 80382-23-6.mol

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Loxoprofen sodium Property

storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO: soluble
form: A solid
color: White to off-white
InChI: InChI=1S/C15H18O3.Na.H/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16;;/h5-8,10,13H,2-4,9H2,1H3,(H,17,18);;
InChIKey: ALZXNWUYLUBHJL-UHFFFAOYSA-N
SMILES: C(C1CCCC1=O)C1C=CC(C(C)C(=O)O)=CC=1.[NaH]
CAS DataBase Reference: 80382-23-6(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: L472900
Product name: LoxoprofenSodium(Mixtureofdiastereomers)
Packaging: 25g
Price: $140
Updated: 2021/12/16

TRC

Product number: L472900
Product name: LoxoprofenSodium(Mixtureofdiastereomers)
Packaging: 100g
Price: $275
Updated: 2021/12/16

Usbiological

Product number: 015693
Product name: Loxoprofen Sodium
Packaging: 25mg
Price: $446
Updated: 2021/12/16

ChemScene

Product number: CS-0013894
Product name: Loxoprofen(sodium)
Purity: ≥98.0%
Packaging: 10mg
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BL164648
Product name: Loxoprofen sodium
Packaging: 100mg
Price: $50
Updated: 2021/12/16

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Loxoprofen sodium Chemical Properties,Usage,Production

Description

Loxoprofen sodium i s an antiinflammatory/analgesic agent useful in the management of rheumatoid arthritis and related disorders. It is converted in vivo to the corresponding trans-hydroxycyclopentane analog, through which it appears to exert its activity.

Originator

Sankyo (Japan)

Uses

anti-inflammatory

Definition

ChEBI: A hydrate that is the dihydrate form of loxoprofen sodium. The parent acid, loxoprofen, is a prodrug that is rapidly converted to its active trans-alcohol metabolite following oral administration.

brand name

LOXONIN

Mechanism of action

As most NSAIDs, loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid.

Side effects

Adverse effects include anorexia, nausea, vomiting, bleeding, anemia, diarrhea, and constipation.

Synthesis

68767-14-6

80382-23-6

General procedure for the synthesis of sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionate from 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionic acid: 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionic acid and methanol were added into a round-bottomed flask, and 1 equivalent of aqueous sodium hydroxide was added to the above solution drop by drop, and the reaction was stirred for 1 hour at room temperature. Upon completion of the reaction, a decompression distillation was carried out at 50-55°C to remove the solvent. Subsequently, a 5% aqueous solution of ethyl acetate was added to the residue, heated until dissolved and then slowly cooled to room temperature. Crystallization was induced by the addition of crystal seeds during cooling and stirring was continued for 5-6 hours at 0-5°C until a suspension was formed. Finally, the solid was collected by filtration to give loxoprofen sodium dihydrate in 95% yield and 99.1% HPLC purity.

References

[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 21, p. 7879 - 7882
[2] Patent: CN107176942, 2017, A. Location in patent: Paragraph 0067; 0068; 0069
[3] Patent: CN108440274, 2018, A. Location in patent: Paragraph 0076; 0077; 0078; 0079; 0080

Loxoprofen sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Loxoprofen sodium Suppliers

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View Lastest Price from Loxoprofen sodium manufacturers

Wuhan JiyunZen Tech Co., Ltd.

Product: Loxoprofen sodium 80382-23-6
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-14

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Loxoprofen sodium 80382-23-6
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 1000kg
Release date: 2021-09-10

Hebei Chuanghai Biotechnology Co., Ltd

Product: Loxoprofen sodium 80382-23-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-06

80382-23-6, Loxoprofen sodiumRelated Search:

Methanol Silicone oil (high temperature) Methylcyclopentane Acetonitrile Tri(o-tolyl)phosphine Sodium formate Diclofenac sodium Sodium hydroxide Sodium bicarbonate PHENYL VALERATE Basic Violet 1 Sodium gluconate Sodium chloride Sodium carbonate Sodium propionate Sodium acetate Chlorodimethylphenylsilane Methylparaben

alpha-methyl-4-((2-oxocyclopentyl)methyl)benzeneacetatesodiumsaltdihydrate

benzeneaceticacid,alpha-methyl-4-((2-oxocyclopentyl)methyl)-,sodiumsalt,di

cs-600

loxoprofensodium(patented-nosupply)

Loxoprofen sodium dihydrate, >=99%

Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate

sodium 2-[4-[(2-oxocyclopentyl)methyl]phenyl]propanoate dihydrate

2-{4-[(2-Oxocyclopentyl)methyl]phenyl}propanoic acid sodium salt

loxoprofensodiumdihydrate

sodium2-(4-(2-oxocyclopentylmethyl)phenyl)propionatedihydrate

LOXOPROFEN NA

MONOSODIUM2-[4-(2-OXOCYCLOPENTYLMETHYL)PHENYL]PROPANOATEDIHYDRATE(LOXOPROFENSODIUM)

Benzeneacetic acid, a-methyl-4-[(2-oxocyclopentyl)methyl]-, sodium salt (9CI)

CS 600 (antiinflammatory)

Loxonin

Sodium 2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propionate

LOXOPROFEN SODIUM

sodium 2-[4-(2-oxocyclopentyl-1-methyl)phenyl]propionate dihydrate

2-[p-(2-Oxocyclopentylmethyl)phenyl]propionic acid sodium salt

Unastin

α-Methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic acid sodium salt

SodiuM Loxoprofen

Loxoprofen sodiuM hydrate

Loxoprofen SodiuM USP

Loxoprofen SodiuM (Mixture of diastereoMers)

loxoprofern sodium

LXP

Loxoprofen sodium USP/EP/BP

Loxoprofen Sodium impurity

oxoprofen sodium hydrate

Loxoprofen SodiumQ: What is Loxoprofen Sodium Q: What is the CAS Number of Loxoprofen Sodium Q: What is the storage condition of Loxoprofen Sodium

Losoprofen Sodium

Dipyridame

Loxoprofen sodium, 10 mM in DMSO

Loxoprofen sodium - Bio-X ?

80382-23-6

80832-23-6

C15H17O32H2ONa

C15H17NaO3

C15H18O3Na

C15H17NaO32H2O

C15H17O3Na

Analgesics

Aromatics

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Antipyretic analgesics

Other APIs

APIS

80382-23-6