ChemicalBook > CAS DataBase List > 4-Chlorobutyryl chloride

4-Chlorobutyryl chloride

Product Name: 4-Chlorobutyryl chloride
CAS No.: 4635-59-0
Chemical Name: 4-Chlorobutyryl chloride
Synonyms: 4-CBC;MONA-002;orobutyryL;4-Chlorobutyryl chlo;4-Chlorbutyrylchlorid;4-Chlorobutyl chloride;-Chlorobutyrylchloride;4-chloroprene chloride;4-CHLOROBUTRYL CHLORIDE;4-chloro-butyrylchlorid
CBNumber: CB5142080
Molecular Formula: C4H6Cl2O
Formula Weight: 141
MOL File: 4635-59-0.mol

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4-Chlorobutyryl chloride Property

Melting point:: -47 °C
Boiling point:: 173-174 °C(lit.)
Density: 1.26 g/mL at 25 °C(lit.)
vapor pressure: 3 mm Hg ( 20 °C)
refractive index: n20/D 1.461(lit.)
Flash point:: 163 °F
storage temp.: Store below +30°C.
solubility: Chloroform, DMSO (Sparingly), Ethyl Acetate (Slightly)
form: Liquid
color: Clear colorless to yellow
explosive limit: 5.5-11.7%(V)
Water Solubility: soluble in diethyl ether, ethanol, slightly soluble in water.
Sensitive: Moisture Sensitive
BRN: 773860
Stability:: Hygroscopic, Moisture Sensitive
InChIKey: CDIIZULDSLKBKV-UHFFFAOYSA-N
CAS DataBase Reference: 4635-59-0(CAS DataBase Reference)
NIST Chemistry Reference: Butanoyl chloride, 4-chloro-(4635-59-0)
EPA Substance Registry System: Butanoyl chloride, 4-chloro- (4635-59-0)

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Safety

Hazard Codes: T,C
Risk Statements: 22-23-35
Safety Statements: 26-28-36/37/39-45-28A
RIDADR: UN 3390 6.1/PG 1
WGK Germany: 1
RTECS: EM1406000
Autoignition Temperature: 824 °F
Hazard Note: Toxic/Corrosive/Moisture Sensitive
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
HS Code: 29159080
Hazardous Substances Data: 4635-59-0(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H330Fatal if inhaled

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C30604
Product name: 4-Chlorobutyryl chloride
Purity: 99%
Packaging: 5g
Price: $44.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 343935
Product name: 4-Chlorobutyryl chloride
Purity: technical grade, 95%
Packaging: 250ml
Price: $77.7
Updated: 2023/06/20

TCI Chemical

Product number: C0824
Product name: 4-Chlorobutyryl Chloride
Purity: >98.0%(GC)(T)
Packaging: 25mL
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: C0824
Product name: 4-Chlorobutyryl Chloride
Purity: >98.0%(GC)(T)
Packaging: 500mL
Price: $99
Updated: 2025/07/31

Sigma-Aldrich

Product number: C30604
Product name: 4-Chlorobutyryl chloride
Purity: 99%
Packaging: 100g
Price: $59
Updated: 2025/07/31

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4-Chlorobutyryl chloride Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to yellow liquid

Uses

4-Chlorobutyryl chloride (4-CBCl) is mainly used in the production of pharmaceuticals and agrochemicals. It is used as pyrazinamide intermediate.

Uses

4-Chlorobutyroyl Chloride is used in the preparation of mitosene and mitosane analogs of Mitomycin C (M371900), an antitumor antibiotic. .

Synthesis Reference(s)

Synthesis, p. 538, 1973 DOI: 10.1055/s-1973-22254

Flammability and Explosibility

Non flammable

Synthesis

96-48-0

4635-59-0

1. γ-Butyrolactone (7.7 mL, 0.1 mol) was added one time under stirring conditions to a mixed solution containing thionyl chloride (8 mL, 0.11 mol) and anhydrous zinc chloride (0.6 g, 4.4 mmol). 2. The reaction mixture was heated at 55 °C with continuous stirring for 12 hours. 3. Upon completion of the reaction, the reaction product was purified by fractional distillation at a pressure of 15-30 mmHg, and fractions with boiling points in the range of 110-125 °C were collected to afford the intermediate 4-chlorobutanoyl chloride (10.4 g, 74 mmol, 74% yield). 4. The resulting intermediate 4-chlorobutanoyl chloride was slowly (over 15 min) added dropwise to a mixed solution of pyridine (6 mL, 74 mmol) and tert-butanol (8.75 mL, 92 mmol) cooled to 0 °C. The solution was then added dropwise to a mixture of pyridine (6 mL, 74 mmol) and tert-butanol (8.75 mL, 92 mmol). 5. After the dropwise addition was completed, the reaction mixture was stirred at room temperature for 4 hours. 6. After completion of the reaction, the mixture was partitioned between water and ether, and the aqueous layer was acidified with concentrated sulfuric acid and extracted with ether (3 x 50 mL). 7. The organic layers were combined and washed sequentially with 1N HCl solution (3 x 100 mL), water (100 mL) and saturated NaCl solution (100 mL). 8. Collect the organic layer, dry with anhydrous Na2SO4, filter and remove the solvent in vacuum. 9. Purification by silica gel column chromatography using 100% dichloromethane as eluent (Rf = 0.9) gave the target product 9a as a clear oil in 25% yield (3.28 g, 18.35 mmol). 10. The structure of the product was confirmed by 1H NMR (CDCl3): δ 3.59 (t, 2H, CH2), 2.41 (t, 2H, CH2), 2.05 (t, 2H, CH2), 1.45 (s, 9H, CH3).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 3, p. 1124 - 1130
[2] Patent: WO2005/40109, 2005, A1. Location in patent: Page/Page column 66
[3] Russian Journal of Organic Chemistry, 1996, vol. 32, # 1, p. 21 - 24
[4] Canadian Journal of Chemistry, 1993, vol. 71, # 8, p. 1152 - 1168
[5] Journal of the American Chemical Society, 1957, vol. 79, p. 1455,1457

4-Chlorobutyryl chloride Preparation Products And Raw materials

Raw materials

Zinc chloride Gamma Butyrolactone

Preparation Products

4-Chlorophenyl cyclopropyl ketone Levetiracetam Terfenadine Cyclopropanecarboxylic acid

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View Lastest Price from 4-Chlorobutyryl chloride manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 4-Chlorobutyryl chloride 4635-59-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-09-26

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Chlorobutyryl chloride 4635-59-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-28

Jinan Jianfeng Chemical Co., Ltd

Product: 4-Chlorobutyryl chloride 4635-59-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 2t
Release date: 2024-09-09

4635-59-0, 4-Chlorobutyryl chlorideRelated Search:

Calcium chloride Polychloroprene Benzoyl chloride Sulfuryl chloride Butyryl chloride Zinc chloride Sodium chloride Choline chloride Oxalyl chloride Thionyl chloride Tosyl chloride Ammonium chloride Pivaloyl chloride Chloroacetyl chloride Potassium chloride H-NVA-NH2 HCL 1-Pyrrolidineaceticacid,alpha-ethylidene-2-oxo-,(alphaZ)-(9CI) 2-aminobutanenitrile

4-chloro-butanoylchlorid

4-Chlorobutyl chloride

4-chloro-butyrylchlorid

-Chlorobutyrylchloride

4-ChlorobutyrylChloride95%

4-Chlorobutyrylchloride,98%

R-CHLOROBUTYRYL CHLORIDE

Butanoyl chloride, 4-chloro-

4-Chlorbutyrylchlorid

4-CHLOROBUTRYL CHLORIDE

4-CHLOROBUTRYL CHLORIDE pure

4-C4-CHLOROBUTYRYL CHLORIDE

γ-chloro-butyryl chloride γ-chloro-butyryl chloride

1,4-Dichloro-1-butanone

4-Chlorobutyryl chloride, 98% 250ML

4-Chlorobutyryl chlo

4-CHLOROBUTYRYL CHLORIDE FOR SYNTHESIS

(4-chlorobutanoyl)chloranuide

A synthetic chloride 4 -

MONA-002

gamma-chlorobutyroylchloride

gamma-Chlorobutyryl chloride

gamma-chlorobutyrylchloride

gamma-Chloro-n-butyryl chloride

4-Chlorobutanoic acid chloride

4-CHLOROBUTANOYLCHLORIDE

4-CHLOROBUTYRIC ACID CHLORIDE

4-CHLOROBUTYROYL CHLORIDE

4-CHLOROBUTYRYL CHLORIDE

4-CBC

4-Chlorobutyrylcy Chloride

4-CHLOROBUTYRYL CHLORIDE, TECH., 95%

orobutyryL

4-ChlorobutyrylChloride&gt

Levetiracetam Impurity 33

4-CHLOROBUTANOIC CHLORIDE

4-chloroprene chloride

4-Chlorobutyryl Chloride pure, 98%

4-CHLOROBUTYRYL CHLORIDE Extra Pure

4-Chlorobutyryl chloride (4-CBC)

5. 4-Chlorobutyryl Chloride

4 CHLORO BUTRYL CHLORIDE(4-CBC)

4635-59-0

35-59-0

4625-59-0

ClCH23COCl

ClCH2CH2CH2COCl

C4H6CI2O

Organic Building Blocks

Acid Halides

Building Blocks

Carbonyl Compounds

Acid Halides

Building Blocks

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

Acid Halides