4-Methylthiophenylacetic acid
Application- Product Name
- 4-Methylthiophenylacetic acid
- CAS No.
- 16188-55-9
- Chemical Name
- 4-Methylthiophenylacetic acid
- Synonyms
- RARECHEM AL BO 0923;4-Methylthiophenylac;Etoricoxib Impurity 53;4-(Methylthio)fenylazijnzuur;4-(methylthio)ohenylacetic acid;4-(METHYLTHIO)PHENYLACETIC ACID;4-(Methylthio)benzeneacetic acid;4-(Methylthio)phenylacetic acid,98%;4-(Methylthio)phenylacetic acid 99%;2-(4-(methylthio)phenyl)acetic acid
- CBNumber
- CB5145142
- Molecular Formula
- C9H10O2S
- Formula Weight
- 182.24
- MOL File
- 16188-55-9.mol
4-Methylthiophenylacetic acid Property
- Melting point:
- 97-98 °C(lit.)
- Boiling point:
- 337.4±25.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- powder to crystal
- pka
- 4.34±0.10(Predicted)
- color
- White to Yellow to Orange
- InChI
- InChI=1S/C9H10O2S/c1-12-8-4-2-7(3-5-8)6-9(10)11/h2-5H,6H2,1H3,(H,10,11)
- InChIKey
- AHMLFHMRRBJCRM-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=CC=C(SC)C=C1
- CAS DataBase Reference
- 16188-55-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 396591
- Product name
- 4-(Methylthio)phenylacetic acid
- Purity
- 99%
- Packaging
- 1g
- Price
- $60.7
- Updated
- 2025/07/31
- Product number
- M2874
- Product name
- 4-(Methylthio)phenylacetic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- M2874
- Product name
- 4-(Methylthio)phenylacetic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $152
- Updated
- 2025/07/31
- Product number
- M725578
- Product name
- 4-(Methylthio)phenylacetic Acid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- D365
- Product name
- 4-(Methylthio)phenylacetic Acid
- Packaging
- 5g
- Price
- $41
- Updated
- 2021/12/16
4-Methylthiophenylacetic acid Chemical Properties,Usage,Production
Application
Methylthiophenylacetic acid is a key intermediate in the preparation of etoricoxib. The traditional method involves the hydrolysis of 4-methylthioacetophenone via the Willgerodt-Kindler rearrangement. In the preparation of this compound, the Willgerodt-Kindler rearrangement reaction is carried out using sublimed sulfur and morpholine as reactants to prepare a thioamide intermediate, which is then hydrolyzed to yield 4-methylthiophenylacetic acid.
Chemical Properties
Cream crystalline powder
General Description
TiO2 photocatalytic one-electron oxidation of 4-(methylthio)phenylacetic acid has been reported by time-resolved diffuse reflectance spectroscopy.
Synthesis
1878-66-6
5188-07-8
16188-55-9
1. 10 g of 4-bromophenylacetic acid was dissolved in 20 mL of DMF under nitrogen protection. 2. 5.0 g of sodium methanethiol and 0.5 g of copper powder were added for nitrogen displacement. 3. The reaction mixture was heated to 130 °C under nitrogen protection and the reaction was stirred for 24 hours. 4. After the reaction was completed, it was cooled to room temperature. 5. The reaction mixture was processed according to the method of Example 1 to finally obtain 4-methylthiophenylacetic acid in 79.3% yield. Alternative steps: 1. 10 g of 4-bromophenylacetic acid was dissolved in 20 mL of DMF under nitrogen protection. 2. 5.0 g of sodium methanethiol and 0.1 g of cuprous bromide were added for nitrogen substitution. 3. The reaction mixture was heated to 130 °C under nitrogen protection and the reaction was stirred for 4 hours. 4. Upon completion of the reaction, the mixture was cooled to room temperature, 5mL of 40% NaOH solution was added and stirred for 10 minutes. 5. Extracted twice with 25mL of ethyl acetate and combined the organic phases. 6. Add 50mL of ethyl acetate and adjust pH to 2-4 with 10% dilute sulfuric acid. 7. Collect the ethyl acetate layer and wash with 10mL of water. 8. Concentrate ethyl acetate to about 20mL by distillation, add 20mL hexane. 9. Heat to reflux to completely dissolve the solid, slowly cool to room temperature and filter to obtain yellow crystals. 10. 6.38g of 4-methylthiophenylacetic acid was obtained after drying in 76.1% yield.
References
[1] Patent: CN105646306, 2016, A. Location in patent: Paragraph 0011
4-Methylthiophenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-Methylthiophenylacetic acid Suppliers
- Tel
- --
- Fax
- --
- info@cm-finechemicals.com
- Country
- Switzerland
- ProdList
- 1186
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 130
- Advantage
- 58
View Lastest Price from 4-Methylthiophenylacetic acid manufacturers
- Product
- 4-Methylthiophenylacetic acid 16188-55-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 4-Methylthiophenylacetic acid 16188-55-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-26
- Product
- 4-Methylthiophenylacetic acid 16188-55-9
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12