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METHYL 2-AMINO-5-METHOXYBENZOATE

Product Name
METHYL 2-AMINO-5-METHOXYBENZOATE
CAS No.
2475-80-1
Chemical Name
METHYL 2-AMINO-5-METHOXYBENZOATE
Synonyms
Methyl 6-amino-m-anisate;Methyl 5-methoxyanthranilate;Methyl2-amino-5-methoxybenzoate,96%;2-Amino-5-methoxybenzoic acid methyl ester;Benzoic acid, 2-aMino-5-Methoxy-, Methyl ester
CBNumber
CB51486729
Molecular Formula
C9H11NO3
Formula Weight
181.19
MOL File
2475-80-1.mol
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METHYL 2-AMINO-5-METHOXYBENZOATE Property

Melting point:
37-38℃
Boiling point:
298.8±20.0 °C(Predicted)
Density 
1.179±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
2.70±0.10(Predicted)
Appearance
Light brown to brown Solid
Water Solubility 
Slightly Soluble (1.1 g/L) (25°C) in water.
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Safety

HS Code 
2922500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
M328730
Product name
Methyl2-Amino-5-methoxybenzoate
Packaging
10g
Price
$330
Updated
2021/12/16
AK Scientific
Product number
J97440
Product name
Methyl2-amino-5-methoxybenzoate
Packaging
5g
Price
$55
Updated
2021/12/16
Matrix Scientific
Product number
073280
Product name
Methyl 2-amino-5-methoxybenzoate
Purity
95+%
Packaging
1g
Price
$135
Updated
2021/12/16
Apolloscientific
Product number
OR912063
Product name
Methyl2-amino-5-methoxybenzoate
Purity
98%
Packaging
1g
Price
$182
Updated
2021/12/16
Matrix Scientific
Product number
073280
Product name
Methyl 2-amino-5-methoxybenzoate
Purity
95+%
Packaging
5g
Price
$395
Updated
2021/12/16
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METHYL 2-AMINO-5-METHOXYBENZOATE Chemical Properties,Usage,Production

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Synthesis

2327-45-9

2475-80-1

The general procedure for the synthesis of methyl 2-amino-5-methoxybenzoate from methyl 5-methoxy-2-nitrobenzoate was as follows: methyl 5-methoxy-2-nitrobenzoate (1.60 g, 7.58 mmol) was dissolved in ethyl acetate (14 mL), and 10% palladium-carbon catalyst (containing 50% water, 320 mg) was added. The reaction was stirred at 20-25°C for 3 hours under hydrogen atmosphere (0.25 MPa). Upon completion of the reaction, the palladium-carbon catalyst was removed by filtration and the solvent was removed by distillation under reduced pressure. The resulting crude product was purified by silica gel column chromatography with hexane/ethyl acetate (10:1 to 5:1) as eluent to afford methyl 2-amino-5-methoxybenzoate (1.29 g, 94% yield). The product was characterized by 1H-NMR (CDCl3), δ: 3.76 (3H, s), 3.88 (3H, s), 5.37 (2H, br), 6.63 (1H, d, J = 8.8 Hz), 6.95 (1H, dd, J = 8.8, 3.1 Hz), 7.35 (1H, d, J = 3.1 Hz).

References

[1] Patent: EP1724268, 2006, A1. Location in patent: Page/Page column 50
[2] Synlett, 2016, vol. 27, # 8, p. 1237 - 1240
[3] Patent: EP1844768, 2007, A1. Location in patent: Page/Page column 25
[4] Patent: CN106478548, 2017, A. Location in patent: Paragraph 0089; 0090; 0121; 0122; 0137; 0138
[5] Australian Journal of Chemistry, 1972, vol. 25, p. 2621 - 2629

METHYL 2-AMINO-5-METHOXYBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 2-AMINO-5-METHOXYBENZOATE Suppliers

China 95 India 3 Switzerland 1 United Kingdom 2 United States 6 Global 107
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
Atlantic Research Chemicals Ltd.
Tel
--
Fax
--
Email
info@atlantic-chemicals.com
Country
United Kingdom
ProdList
5618
Advantage
63
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View Lastest Price from METHYL 2-AMINO-5-METHOXYBENZOATE manufacturers

Career Henan Chemical Co
Product
METHYL 2-AMINO-5-METHOXYBENZOATE 2475-80-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

2475-80-1, METHYL 2-AMINO-5-METHOXYBENZOATERelated Search:

Methyl 2-amino-4,5-dimethoxybenzoate Methyl 2-nitro-3,4,5-trimethoxybenzoate ACIFLUORFEN METHYL ESTER ETHYL 2-AMINO-4,5-DIMETHOXYBENZOATE Methyl 4,5-dimethoxy-2-nitrobenzoate Methyl 2-amino-3,4,5-trimethoxybenzoate METHYL 5-METHOXY-2-NITROBENZOATE ETHYL 4,5-DIMETHOXY-2-NITROBENZOATE Bifenox 2-Amino-5-methoxybenzoic acid 6,7-DIMETHOXY-2-(3-NITROPHENYL)-4H-3,1-BENZOXAZIN-4-ONE Tritoqualine METHYL 2-AMINO-4,5-DIETHOXYBENZOATE CBI-BB ZERO/005500 458L 6,7-DIMETHOXY-2-METHYL-BENZO[D][1,3]OXAZIN-4-ONE RARECHEM AL BI 0176 6,7-DIMETHOXY-2-(4-METHYLPHENYL)-4H-3,1-BENZOXAZIN-4-ONE

  • Benzoic acid, 2-aMino-5-Methoxy-, Methyl ester
  • 2-Amino-5-methoxybenzoic acid methyl ester
  • Methyl 5-methoxyanthranilate
  • Methyl 6-amino-m-anisate
  • Methyl2-amino-5-methoxybenzoate,96%
  • 2475-80-1