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Jaceosidin

Product Name
Jaceosidin
CAS No.
18085-97-7
Chemical Name
Jaceosidin
Synonyms
Jacosidin;Jaseosidin;JACEOSIDIN;Jacesiolin;Jaceosidin-RM;Brown centaurin;Jaceosidin, 98%min;Jaceosidin, 10 mM in DMSO;6-Hydroxyluteolin 3',6-dimethyl ether;4',5,7-Trihydroxy-3',6-dimethoxyflavone
CBNumber
CB51515205
Molecular Formula
C17H14O7
Formula Weight
330.29
MOL File
18085-97-7.mol
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Jaceosidin Property

Melting point:
259-260 °C
Boiling point:
619.0±55.0 °C(Predicted)
Density 
1.483±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated), Pyridine (Slightly)
form 
Solid
pka
6.47±0.40(Predicted)
color 
Pale Yellow to Light Yellow
Stability:
Hygroscopic
InChI
InChI=1S/C17H14O7/c1-22-13-5-8(3-4-9(13)18)12-6-10(19)15-14(24-12)7-11(20)17(23-2)16(15)21/h3-7,18,20-21H,1-2H3
InChIKey
GLAAQZFBFGEBPS-UHFFFAOYSA-N
SMILES
C1(C2=CC=C(O)C(OC)=C2)OC2=CC(O)=C(OC)C(O)=C2C(=O)C=1
LogP
1.300 (est)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19758
Product name
Jaseosidin
Purity
≥98%
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
19758
Product name
Jaseosidin
Purity
≥98%
Packaging
5mg
Price
$150
Updated
2024/03/01
Cayman Chemical
Product number
19758
Product name
Jaseosidin
Purity
≥98%
Packaging
10mg
Price
$264
Updated
2024/03/01
Cayman Chemical
Product number
19758
Product name
Jaseosidin
Purity
≥98%
Packaging
25mg
Price
$576
Updated
2024/03/01
Usbiological
Product number
300511
Product name
Jaceosidin
Packaging
10mg
Price
$546
Updated
2021/12/16
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Jaceosidin Chemical Properties,Usage,Production

Chemical Properties

Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from the leaves of Ailanthus, long-leaved arnica flowers, silver artemisia above ground, stevia, the leaves of the ground yellow, the above ground parts of the vine.

Uses

Jaceosidin exhibits anti-allergic, anti-inflammatory and apoptosis inducing activities.

Definition

ChEBI: A trihydroxyflavone that is flavone with hydroxy groups at positions 5, 7 and 4' and methoxy groups at positions 3' and 6. Isolated from Salvia tomentosa and Artemisia asiatica, it exhibits anti-allergic, anti-inflammatory and apo tosis inducing activties.

in vivo

Jaceosidin (10 and 20 mg/kg, p.o., once a day for 3 days) blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates in mice[3].
? Jaceosidin (10, 20 mg/kg, p.o.) suppresses COX-2 expression and NF-κB activation in mice[3].
? Jaceosidin (20 mg/kg, p.o. for 2 hours) reduces hind paw edema volume in rats[3].

Animal Model:5-week-old male BALB/c mice (23-26 g)[3]
Dosage:10 and 20 mg/kg
Administration:P.O. once a day for 3 days
Result:Decreased the volumes of exudates (inflammatory markers), cell number and protein levels. Inhibited TNF-α by 46.7% and 50.8%, IL-1β by 46.0% and 44.7%, and PGE2 by 21.7% and 16.9%, respectively, at 20 mg/kg. Blocked COX-2 expression and NF-κB activation.
Animal Model:Male Sprague-Dawley rats (180-200 g)[3]
Dosage:20 mg/kg
Administration:P.O., for 2 hour
Result:Reduced hind paw edema volume by 27.1% at 1 h, and 24.0% at 2 h, respectively.

IC 50

Bax; COX-2

Jaceosidin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Jaceosidin manufacturers

Hebei Dangtong Import and export Co LTD
Product
Jaceosidin 18085-97-7
Price
US $1000.00-870.00/g
Min. Order
1g
Purity
99%
Supply Ability
100Tons
Release date
2023-09-21
Hangzhou ICH Biofarm Co., Ltd
Product
Jaceosidin 18085-97-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98% HPLC
Supply Ability
500kg
Release date
2023-07-06
Shanghai Standard Technology Co., Ltd.
Product
Jaceosidin 18085-97-7
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-13

18085-97-7, JaceosidinRelated Search:

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  • JACEOSIDIN
  • 3',6-Dimethoxy-4',5,7-trihydroxyflavone
  • 5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
  • 6-Hydroxyluteolin 3',6-dimethyl ether
  • Jacesiolin
  • 4',5,7-Trihydroxy-3',6-dimethoxyflavone
  • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-
  • 5,7-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6-methoxy-chromen-4-one
  • 5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-chromen-4-one
  • Jaseosidin
  • 4',5,7-Trihydroxy-3',6-dimethoxyflavone 5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxychromen-4-one
  • Jacosidin
  • Brown centaurin
  • Jaceosidin-RM
  • Jaceosidin, 10 mM in DMSO
  • Jaceosidin, 98%min
  • 18085-97-7
  • 8085-97-7
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract