ChemicalBook > CAS DataBase List > SNS-032

SNS-032

Product Name
SNS-032
CAS No.
345627-80-7
Chemical Name
SNS-032
Synonyms
CS-202;SNS-032;BMS-387032;BMS-3870032;SNS-032, >=99%;BMS-387032/SNS-032;SNS0032(BMS-387032);SNS-032, 98.5%, a selective CDK2 inhibitor;BMS-387032; SNS 032; SNS032; BMS 387032; BMS387032;1-diMethylethyl)-2-oxazolyl]Methyl]thio]-2-thiazolyl]-
CBNumber
CB51518701
Molecular Formula
C17H24N4O2S2
Formula Weight
380.53
MOL File
345627-80-7.mol
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SNS-032 Property

Melting point:
171-173 °C
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
7.33±0.70(Predicted)
color 
White to Off-White
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Safety

HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2218
Product name
SNS-032
Purity
≥98% (HPLC)
Packaging
5MG
Price
$56.52
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2218
Product name
SNS-032
Purity
≥98% (HPLC)
Packaging
25MG
Price
$306
Updated
2024/03/01
Cayman Chemical
Product number
17904
Product name
SNS-032
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
17904
Product name
SNS-032
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
17904
Product name
SNS-032
Purity
≥98%
Packaging
10mg
Price
$172
Updated
2024/03/01
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SNS-032 Chemical Properties,Usage,Production

Description

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively. It is selective for these kinases and displays no additional activity against a panel of 190 kinases (IC50s = >1,000 nM). SNS-032 can block the cell cycle, inhibit transcription, and induce apoptosis in multiple myeloma RPMI-8226 cells with an IC90 value of 0.3 μM. This compound has been shown to induce apoptosis by inhibiting the transcription of the anti-apoptotic proteins, Mcl-1 and XIAP.

Chemical Properties

Off-White Solid

Uses

SNS 032 is a selective inhibitor of Cyclin-dependent Kinase (CDK) 2,7, and 9.

Definition

ChEBI: N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide is a secondary carboxamide resulting from the formal condensation of the carboxy group of piperidine-4-carboxylic acid with the amino group of 5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-amine. It is an ATP-competitive inhibitor of CDK2, CDK7 and CDK9 kinases and exhibits anti-cancer properties. It has a role as an apoptosis inducer, an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor and an angiogenesis inhibitor. It is a piperidinecarboxamide, a member of 1,3-oxazoles, a member of 1,3-thiazoles, an organic sulfide and a secondary carboxamide.

storage

Store at -20°C

References

[1]. tong w.g., chen r., plunkett w., et al. phase i and pharmacologic study of sns-032, a potent and selective cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma. journal of clinical oncology, 2010, 28(18):3015- 3022.
[2]. chipumuro e., marco e., christensen c.l., et al. cdk7 inhibition suppresses super-enhancer-linked oncogenic transcription in mycn-driven cancer. cell, 2014, 159:1-14.
[3]. meng h., jin y.m., liu h., et al. sns-032 inhibits mtorc1/mtorc2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against akt. journal of hematology & oncology, 2013, 6:18.
[4]. chen r., wierda w.g., chubb s., et al. mechanism of action of sns032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. blood, 2009, 113(19):4637-4645.

SNS-032 Preparation Products And Raw materials

Raw materials

Preparation Products

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SNS-032 Suppliers

Canada 1 China 139 India 2 United Kingdom 3 United States 21 Global 166
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from SNS-032 manufacturers

Career Henan Chemical Co
Product
N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide 345627-80-7
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
1kg; 10kg; 25kg
Release date
2020-01-07

345627-80-7, SNS-032Related Search:

3,3-Dimethyl-1-butyne N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide hydrochloride N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea Y27632 (hydrochloride) Alisertib (MLN8237) PD 0332991 HCl (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Flavopiridol (Alvocidib) HCl Olaparib Hexahydroisonicotinamide 1-BOC-PIPERIDINE-4-CARBOXYLIC ACID [5-(5-TERT-BUTYL-OXAZOL-2-YLMETHYLSULFANYL)-THIAZOL-2-YL]-AMIDE SNS-032

  • BMS-387032; SNS 032; SNS032; BMS 387032; BMS387032
  • CS-202
  • SNS 032; SNS032; SNS-032; BMS387032; BMS 387032; BMS-387032
  • BMS-3870032 N-[5-[(5-tert-Butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide
  • N-[5-[(5-tert-Butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide SNS-032 (BMS-387032)
  • N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamid
  • SNS-032, >=99%
  • SNS-032, 98.5%, a selective CDK2 inhibitor
  • N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide
  • BMS-387032
  • 4-Piperidinecarboxamide, N-(5-(((5-(1,1-dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-
  • N-(5-((5-Tert-Butyloxazol-2-yl)methylthio)thiazol-2-yl)piperidine-4-carboxamide
  • 1-diMethylethyl)-2-oxazolyl]Methyl]thio]-2-thiazolyl]-
  • N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide
  • N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide(BMS-3870032)
  • BMS-3870032
  • SNS0032(BMS-387032)
  • N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide USP/EP/BP
  • N-[5-[(5-tert-Butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thia...
  • SNS-032
  • BMS-387032/SNS-032
  • N-(5-(((4-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)piperidine-4-carboxamide
  • 345627-80-7
  • C17H24N4O2S2
  • Inhibitors
  • Specific and potent inhibitor of cyclin-dependent kinases (CDK) 2, 7 and 9.
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals. Sulfur & Selenium Compounds
  • Pharmaceuticals
  • Inhibitor of cyclin-dependent kinases (CDK) 2, 7 and 9.