Methylprednisolone sodium succinate

Product Name: Methylprednisolone sodium succinate
CAS No.: 2375-03-3
Chemical Name: Methylprednisolone sodium succinate
Synonyms: METHYLPREDNISOLONE SODIUM SUCCINATE;6α-methylprednisolone 21-hemisuccinate sodium salt;1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-SUCCINATE, SODIUM SALT;6ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT;(6alpha,11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-pregna-1,4-diene-3,20-dione monosodium salt;u9088;Metypred;NSC 48989;succinate);solu-medrol
CBNumber: CB5163715
Molecular Formula: C26H33O8.Na
Formula Weight: 496.53
MOL File: 2375-03-3.mol

More

Less

Methylprednisolone sodium succinate Property

Melting point:: >186°C (dec.)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: lyophilized powder
color: White to Off-White
biological source: synthetic
Water Solubility: water: 50mg/mL, clear, colorless to faintly yellow
InChIKey: FQISKWAFAHGMGT-JXAFMBTDNA-M
SMILES: [C@]12(C[C@@H](C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@H](C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)COC(=O)CCC([O-])=O)O)C)[H].[Na+] |&1:0,2,9,11,13,15,17,20,r|
CAS DataBase Reference: 2375-03-3(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: T
Risk Statements: 61-40
Safety Statements: 53-22-36/37/39-45
WGK Germany: 3
RTECS: TU4154060
Toxicity: LD50 oral in rat: > 5gm/kg

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H351Suspected of causing cancer

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M3781
Product name: 6α-Methylprednisolone 21-hemisuccinate sodium salt
Purity: lyophilized powder
Packaging: 25MG
Price: $78.7
Updated: 2023/06/20

Sigma-Aldrich

Product number: M3781
Product name: 6α-Methylprednisolone 21-hemisuccinate sodium salt
Purity: lyophilized powder
Packaging: 250MG
Price: $411
Updated: 2023/06/20

Sigma-Aldrich

Product number: M3781
Product name: 6α-Methylprednisolone 21-hemisuccinate sodium salt
Purity: lyophilized powder
Packaging: 1G
Price: $1300
Updated: 2023/06/20

Usbiological

Product number: 220287
Product name: Succinate
Packaging: 100Tests
Price: $1048
Updated: 2021/12/16

TRC

Product number: M326725
Product name: 6α-Methylprednisolone21-HemisuccinateSodiumSalt
Packaging: 100mg
Price: $140
Updated: 2021/12/16

More

Less

Methylprednisolone sodium succinate Chemical Properties,Usage,Production

Description

Methylprednisolone Sodium Succinate is the sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. It is converted into active prednisolone in the body, which activates glucocorticoid receptor-mediated gene expression. This includes inducing the synthesis of the anti-inflammatory protein IkappaB-alpha and inhibiting the synthesis of nuclear factor kappa B (NF-kappaB). As a result, proinflammatory cytokine production, such as IL-1, IL-2, and IL-6, is down-regulated, and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.

Uses

6α-Methylprednisolone 21-Hemisuccinate is a glucocorticosteroid used in anti-inflammatory medication in the treatment of spinal cord injuries.

Uses

6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting.

Definition

ChEBI: Methylprednisolone sodium succinate is a corticosteroid hormone.

brand name

A-Methapred (Abbott); A-Methapred (Hospira); Solu-Medrol (Pharmacia & Upjohn).

Biochem/physiol Actions

Glucocorticoid with slightly longer half-life than that of prednisolone.

Side effects

Methylprednisolone Sodium Succinate is commonly given by injection and common side effects include: injection site pain/redness/swelling, nausea, vomiting, heartburn, headache, dizziness, difficulty sleeping, appetite changes, increased sweating, acne, increased blood sugar, sore throat, fever, chills, cough, white spots in the mouth. Serious side effects manifest as abnormal weight gain, menstrual disorders, bone/joint pain, easy bruising/bleeding, mental/mood changes, fast/slow/irregular heartbeat, stomach/intestinal bleeding symptoms, seizures, liver problems, and symptoms of severe allergic reactions. Contact your doctor if any of these serious adverse symptoms occur.

Methylprednisolone sodium succinate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Methylprednisolone sodium succinate Suppliers

Canada 1 China 108 Europe 2 Germany 1 India 10 Switzerland 1 United Kingdom 3 United States 27 Global 153

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

TargetMol Chemicals Inc.

Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Country: United States
ProdList: 19881
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

Sciencelab.com, Inc.

Tel: --
Fax: --
Email: accounting@sciencelab.com
Country: United States
ProdList: 4159
Advantage: 82

Lab Express

Tel: --
Fax: --
Email: sales@labexpress.com
Country: United States
ProdList: 1577
Advantage: 67

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

Steraloids Inc.

Tel: --
Fax: --
Email: sales@steraloids.com
Country: United States
ProdList: 2357
Advantage: 68

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

Spectrum Chemicals & Laboratory Products

Tel: --
Fax: --
Email: sales@spectrumchemical.com
Country: United States
ProdList: 6699
Advantage: 77

2375-03-3, Methylprednisolone sodium succinateRelated Search:

Kresoxim-methyl Trisodium phosphate Sodium acetate Thiophanate-methyl Methylprednisolone acetate Bensulfuron methyl Sodium bicarbonate Methyl acrylate Prednisolone-21-acetate Sodium benzoate Methylparaben Diclofenac sodium Sodium hydroxide Sodium chloride Prednisolone Hydrocortisone sodium succinate Methylprednisolone Disodium succinate

(6alpha,11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-pregna-1,4-diene-3,20-dione monosodium salt

6ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT

6ALPHA-METHYLPREDNISOLONE 21-HEMISUCCINATE SODIUM SALT

6-ALPHA-METHYLPREDNISOLONE SODIUM SUCCINATE

1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-SUCCINATE, SODIUM SALT

6α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate

6α-methylprednisolone 21-hemisuccinate sodium salt

Methylprednisolone sodium succinate (JAN/USP)

6a-Methylprednisolone 21-sodium hemisuccinate

6a-Methylprednisolone 21-sodium succinate

6a-Methylprednisolone sodium hemisuccinate

6a-Methylprednisolone sodium succinate

6a-Methylpregnisolone 21-sodium succinate

6-Methylprednisolone sodium succinate

Metypred

NSC 48989

Pregna-1,4-diene-3,20-dione, 11b,17,21-trihydroxy-6a-methyl-, 21-(hydrogen succinate), monosodium salt (8CI)

Pregna-1,4-diene-3,20-dione, 11b,17,21-trihydroxy-6a-methyl-, 21-(hydrogen succinate), sodium salt (6CI, 7CI)

METHPREDNISOLONE SODIUM SUCCINATE

METHYLPREDNISOLONE SODIUM SUCCINATE

solu-medrone

succinate)

u9088

urbasonsolubile

Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, monosodium salt, (6alpha,11beta)-

Methylprodnisolone Sodium Succinate

Methylprednisolone Succinate BP93,USP26

11-beta,17,21-trihydroxy-6-alpha-methyl-1,4-pregnadiene-3,20-dione21-(sodium

4-diene-3,20-dione,11-beta,17,21-trihydroxy-6-alpha-methyl-pregna-21-(hyd

6a-methylprednisolone21-hemisuccinate*sodium

rogensuccinate),monosodiumsalt

solu-medrol

Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, monosodium salt, (6a,11b)- (9CI)

Sodium methylprednisolone succinate

Succinic acid, 21-monoester with 11b,17,21-trihydroxy-6a-methylpregna-1,4-diene-3,20-dione, monosodium salt (8CI)

21-(3-Sodiooxycarbonyl-1-oxopropoxy)-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione

Sol-Melcort

6alpha-Methylprednis

Methylprednisolone SodiuM Succinate Sterile Buffer

MethylprednisoloneSodiuM-SuccinateforInjection

6a-Methylprednisolone 21-succinate sodium

21-Succinate sodium salt

Pregna-1,4-diene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-Methyl-, MonosodiuM salt, (6a,11b)-

6α-Methylprednisolone 21-hemisuccinate Sodium

6α-Methylprednisolone21-hemisuccinatesodiumsal

1, 4-PREGNADIEN-6α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE 21-SUCCINATE, SODIUM SALT

6 alpha-Methylprednisolone Sodium Hemisuccinate

Sodium 4-(2-((6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy)-4-oxobutanoate

Levocarnitine Impurity 58

6α-Methylprednisolone Sodium Succinate

6α-Methylprednisolone 21-hemisuccinate sodium salt, 10 mM in DMSO

2375-03-3

2375-3-3

2374-03-3

173553

C26H33NaO8

C26H34O8Na

C26H33O8Na