ChemicalBook > CAS DataBase List > Etamsylate

Etamsylate

Product Name
Etamsylate
CAS No.
2624-44-4
Chemical Name
Etamsylate
Synonyms
ETHAMSYLATE;e141;Phenolsulfonate;md141;eselin;HeMsyl;K-Stat;Sylate;altodor;aglumin
CBNumber
CB5165128
Molecular Formula
C10H17NO5S
Formula Weight
263.31
MOL File
2624-44-4.mol
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Etamsylate Property

Melting point:
125°
Density 
1.3441 (rough estimate)
refractive index 
1.5060 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Very soluble in water, freely soluble in methanol, soluble in anhydrous ethanol, practically insoluble in methylene chloride.
form 
Solid
color 
White to Pale Red
Merck 
14,3722
Stability:
Hygroscopic
InChI
InChI=1S/C6H6O5S.C4H11N/c7-4-1-2-5(8)6(3-4)12(9,10)11;1-3-5-4-2/h1-3,7-8H,(H,9,10,11);5H,3-4H2,1-2H3
InChIKey
HBGOLJKPSFNJSD-UHFFFAOYSA-N
SMILES
C1(S(=O)(=O)O)=CC(=CC=C1O)O.N(CC)CC
CAS DataBase Reference
2624-44-4(CAS DataBase Reference)
EPA Substance Registry System
Ethamsylate (2624-44-4)
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Safety

RTECS 
DB6145000
HS Code 
2921.19.6190
HazardClass 
IRRITANT
Toxicity
LD50 i.v. in mice, rats: 800, 1350 mg/kg (Esteve)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P313Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E1830000
Product name
Etamsylate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
e1830000
Price
$153
Updated
2024/03/01
TCI Chemical
Product number
E1145
Product name
Etamsylate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$30
Updated
2024/03/01
TCI Chemical
Product number
E1145
Product name
Etamsylate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$89
Updated
2024/03/01
TRC
Product number
E889950
Product name
Ethamsylate
Packaging
10mg
Price
$55
Updated
2021/12/16
TRC
Product number
E889950
Product name
Ethamsylate
Packaging
25mg
Price
$70
Updated
2021/12/16
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Etamsylate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Haemostatic / Anti Coagulant

Uses

Hemostatic;prostaglandin synthesis inhibitor

Definition

ChEBI: Etamsylate is a sulfonic acid derivative and an organosulfur compound.

Biological Activity

Etamsylate is a haemostatic agent th at is used for the management of blood loss. Apparently etamsylate increases capillary wall resistance and platelet adhesives by inhibition of the biosynthesis of prostaglandins causing platelet disaggregation in a presence of vascular wound. Recent studies suggest th at etamsylate antagonizes anti-coagulant activity of heparin.

Mechanism of action

Etamsylate is an antihaemorrhagic and vasoprotective agent. It increases platelet adhesiveness and capillary vascular wall resistance, thereby reducing capillary exudation and blood loss.

Clinical Use

Short-term treatment of blood loss in menorrhagia
Prophylaxis of surgical bleeding (unlicensed)

Side effects

Significant: Hypotension (parenteral). Rarely, severe hypersensitivity reaction, including anaphylaxis.
Blood and lymphatic system disorders: Parenteral: Rarely, neutropenia, agranulocytosis, thrombocytopenia.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, abdominal pain or discomfort.
General disorders and administration site conditions: Asthenia (parenteral). Rarely, fever.
Musculoskeletal and connective tissue disorders: Rarely, arthralgia.
Nervous system disorders: Headache.
Skin and subcutaneous tissue disorders: Rash.
Vascular disorders: Rarely, thromboembolism (parenteral).

Metabolism

Etamsylate is excreted unchanged, mainly in the urine.

Etamsylate Preparation Products And Raw materials

Raw materials

Sulfur dioxide Diethylamine Diethylaminoethanol 1,4-Benzoquinone

Preparation Products

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View Lastest Price from Etamsylate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
etamsylate 2624-44-4
Price
US $80.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-04-23
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Etamsylate 2624-44-4
Price
US $0.00/Kg/Drum
Min. Order
25KG
Purity
99.0%~101.0%; BP2010
Supply Ability
50tons/month
Release date
2021-06-08
Henan Suikang Pharmaceutical Co.,Ltd.
Product
Etamsylate 2624-44-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99.0%
Supply Ability
1tons
Release date
2024-04-26

2624-44-4, EtamsylateRelated Search:

Calcium dobesilate Amlodipine Besylate Sulfanilic acid Ethylamine Glycine Benzenesulfonic acid Dodecylbenzenesulphonic acid Ethyl 2-(Chlorosulfonyl)acetate Folic acid Diethylamine hydrochloride ETAMSYLATE FOR INJECTION Diethylamine PHENOLSULFONIC ACID Etamsylate ETAMSYLATE EPE(CRM STANDARD) phosphoric acid

  • altodor
  • e141
  • eselin
  • md141
  • 2,5-dihydroxy-benzenesulfonicacicompd.withdiethylamine
  • 2,5-dihydroxy-benzenesulfonicacicompd.withn-ethylethanamine(1:1)
  • 2,5-dihydroxybenzenesulfonicacidcompd.withn-ethylethanamine
  • 2,5-DihydroxybenzenesulfonicacidcompdwithN-ethylethanamine
  • aglumin
  • ciclonamina
  • cyclonamine
  • dicynene
  • dicynone
  • diethylammonium2,5-dihydroxybenzenesulfonate
  • diethylammoniumcyclohexadien-4-ol-1-one-4-sulfonate
  • diidroxi-1,4-benzenesulfonato-3-di-etilammonium
  • ETAMSYLATE
  • ETHAMSYLATE
  • diethylammonium 2,5-dihydroxybenzenesulphonate
  • Diethylammonium cyclohexadiene-4-ol-1-one-4-sulfonate
  • 2,5-Dihydroxybenzenesulfonic acid N-ethylethanamine
  • N,N-Diethylamine-2,5-dihydroxybenzolsulphonate
  • 2,5-Dihydroxybenzenesulfonic acid diethylamine salt
  • Benzenesulfonic acid, 2,5-dihydroxy-, compd. with diethylamine
  • Benzenesulfonic acid, 2,5-dihydroxy-, compd. with N-ethylethanamine (1:1)
  • Eselin【hemostatic】
  • diethylaMine 2,5-dihydroxybenzenesulfonate
  • 1-hydroxy-4-oxo-2,5-cyclohexadiene-1-sulfonicacidcompd.withdiethylamine
  • EtaMsylate,(S)
  • 2,5-Dihydroxybenzenesulfonic Acid N-EthylethanaMine Salt
  • Biosinon
  • Dicinone
  • HeMsyl
  • K-Stat
  • Sylate
  • EtaMsvlatuM
  • 2,5-Dihydroxybenzenesulfonic acid N-ethylethanamine (1:1)
  • Phenolsulfonate
  • fenhuangyian
  • Etamsylate CRS
  • Etamsylate&gt
  • Etamsylate USP/EP/BP
  • Etamsylater
  • sulfoethylamine
  • EtamsylateQ: What is Etamsylate Q: What is the CAS Number of Etamsylate Q: What is the storage condition of Etamsylate Q: What are the applications of Etamsylate
  • Etamsylate API
  • 2,5-Dihydroxybenzenesulfonic acid N-ethylethanamin
  • Phenolsulfoethylamine
  • tysamine
  • Methanesulfonic Acid Impurity 8
  • Ethamsylate, 10 mM in DMSO
  • 2624-44-4
  • Other APIs
  • For the prevention and treatment of bleeding before surgery, but for intestinal bleeding, bleeding and urinary tract bleeding, etc
  • API
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals