ChemicalBook > CAS DataBase List > Azosemide

Azosemide

Product Name
Azosemide
CAS No.
27589-33-9
Chemical Name
Azosemide
Synonyms
Diart;Luret;SK-110;ple1053;azosemid;Diurapid;AZOSEMIDE;Azosemidum;AZOSEMIDE HPLC;Azosemide USP/EP/BP
CBNumber
CB5200179
Molecular Formula
C12H11ClN6O2S2
Formula Weight
370.84
MOL File
27589-33-9.mol
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Azosemide Property

Melting point:
218-221°
Boiling point:
221°C (rough estimate)
Density 
1.6843 (rough estimate)
refractive index 
1.6100 (estimate)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
3.58±0.10(Predicted)
color 
Crystals
CAS DataBase Reference
27589-33-9(CAS DataBase Reference)
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Safety

Toxicity
LD50 orl-rat: 2545 mg/kg IYKEDH 18,666,87
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A965145
Product name
Azosemide
Packaging
10g
Price
$845
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0001575
Product name
AZOSEMIDE
Purity
95.00%
Packaging
100MG
Price
$727.65
Updated
2021/12/16
AK Scientific
Product number
E592
Product name
Azosemide
Packaging
100mg
Price
$298
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA44032
Product name
Azosemide
Packaging
10mg
Price
$40
Updated
2021/12/16
ChemScene
Product number
CS-0028137
Product name
Azosemide
Purity
>98.0%
Packaging
10mg
Price
$50
Updated
2021/12/16
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Azosemide Chemical Properties,Usage,Production

Description

Azosemide is a high-ceiling diuretic similiar in structure and profile to furosemide, albeit somewhat less potent and less bioavailable. It is useful in the treatment of congestive heart failure and similar edematous conditions.

Originator

Boehringer Manheim (W. Germany)

Uses

Diuretic.

Uses

Azosemide is a high-ceiling diuretic agent. It is used in the treatment of edematous states and hypertension.

Definition

ChEBI: A sulfonamide that is benzenesulfonamide which is substituted at positions 2, 4, and 5 by chlorine, (2-thienylmethyl)amino and 1H-tetrazol-5-yl groups, respectively. It is a diuretic that has been used in the management of oedema and hyp rtension.

Manufacturing Process

The 4-chloro-5-sulfamoyl-2-thenylaminobenzonitrile used as starting material is obtained by the reaction of 4-chloro-2-fluoro-5-sutfamoyl-benzonitrile with thenylamine in anhydrous tetrahydrofuran.
Then the 5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)phenyltetrazole (MP 218° to 221°C, yield 37% of theory) is obtained by the reaction of 4-chloro-5- sulfamoyl-2-thenylaminobenzonitrite (MP 170° to 174°C) with sodium azide and ammonium chloride,

brand name

LURET

Therapeutic Function

Diuretic

Safety Profile

Poison by intraperitoneal andintravenous routes. Moderately toxic by ingestion andsubcutaneous routes. An experimental teratogen. Whenheated to decomposition it emits toxic fumes of Cl-, SOx,and NOx.

Azosemide Preparation Products And Raw materials

Raw materials

Sodium azide Benzonitrile 2-thiophene

Preparation Products

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Azosemide Suppliers

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View Lastest Price from Azosemide manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Azosemide 27589-33-9
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-10-09
Shaanxi Dideu New Materials Co. Ltd
Product
Azosemide 27589-33-9
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-01
Hubei Langyou International Trading Co., Ltd
Product
Azosemide 27589-33-9
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10000kg
Release date
2021-09-01

27589-33-9, AzosemideRelated Search:

Boc-D-Glutamine 2,3,5-Triphenyltetrazolium chloride 1H-Tetrazole-1-acetic acid N,N-Dimethylformamide Acrylamide Tetrazole Polyacrylamide Sulfanilamide Nitrotetrazolium blue chloride 3-Aminobenzenesulfonamide Acetamide Epichlorohydrin Polyamide Chlorantraniliprole Nicotinamide Formamide Difluorochloromethane Chloroacetic acid

  • 2-chloro-5-(1h-tetrazol-5-yl)-4-((2-thienylmethyl)amino)-benzenesulfonamid
  • 2-chloro-5-(1h-tetrazol-5-yl)-n(sup4)-2-thenyl-sulfanilamid
  • SK-110
  • 2-chloro-5-(2H-1,2,3,4-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide
  • 2-chloro-5-(2H-tetrazol-5-yl)-4-(2-thienylmethylamino)benzenesulfonamide
  • 2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide
  • Azosemide Solution, 1000ppm
  • Azosemide Solution, 100ppm
  • Pharmaceutical Intermediate 98% Research Powder cas 27589-33-9 Azosemide
  • 2-chloro-5-(1h-tetrazol-5-yl)-n(sup4)-2-thenylsulfanilamide
  • 5-(4’-chloro-5’-sulfamoyl-2’-thenylaminophenyl)-tetrazole
  • azosemid
  • ple1053
  • AZOSEMIDE
  • 2-chloro-5-(1h-tetrazol-5-yl)-4-(2-thenylamino)benzenesulphonamide
  • 2-CHLORO-5-(1H-TETRAZOL-5-YL)-4-((2-THIENYLMETHYL)AMINO)-BENZENESULFONAMIDE
  • Azosemide(Chemical Name: 2-Chloro-5-(1h-Tertrazol-5-Yl)-N4-(2-Thenyl))
  • AZOSEMIDE HPLC
  • Diart
  • Diurapid
  • Luret
  • 2-Chloro-5-(1H-tetrazol-5-y1)-4-[(2-thienylmethyl)amino]benzenesulfona-Mide
  • Azosemidum
  • Pharmaceutical Intermediate 98% Research Powder Azosemide
  • Benzenesulfonamide, 2-chloro-5-(2H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]-
  • Azosemide USP/EP/BP
  • 2-Chloro-5-(1H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide
  • Azosemide, 10 mM in DMSO
  • 27589-33-9
  • C12H11CIN6O2S2
  • C12H11ClN6O2S2