ChemicalBook > CAS DataBase List > 4-Fluorobenzonitrile
4-Fluorobenzonitrile
- Product Name
- 4-Fluorobenzonitrile
- CAS No.
- 1194-02-1
- Chemical Name
- 4-Fluorobenzonitrile
- Synonyms
- PFBN;P-FLUOROBENZONITRILE;For fluorobenzonitrile;4-fluoronitrile;4-florobenzonitrile;P-Fluorobenzonitile;4-fluoro-benzonitril;p-Cyanofluorobenzene;p-fluoro-benzonitril;4-CYANOFLUOROBENZENE
- CBNumber
- CB5200760
- Molecular Formula
- C7H4FN
- Formula Weight
- 121.11
- MOL File
- 1194-02-1.mol
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4-Fluorobenzonitrile Property
- Melting point:
- 32-34 °C (lit.)
- Boiling point:
- 188 °C/750 mmHg (lit.)
- Density
- 1.1070
- refractive index
- 1.4925
- Flash point:
- 150 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Chloroform, Ethyl Acetate
- form
- Crystalline Low Melting Solid
- color
- White
- Water Solubility
- Insoluble in water.
- BRN
- 2041517
- Exposure limits
- NIOSH: IDLH 25 mg/m3
- InChIKey
- AEKVBBNGWBBYLL-UHFFFAOYSA-N
- CAS DataBase Reference
- 1194-02-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzonitrile, 4-fluoro-(1194-02-1)
- EPA Substance Registry System
- 4-Fluorobenzonitrile (1194-02-1)
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Safety
- Hazard Codes
- Xn,T,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 36/37-36/37/39-26-36
- RIDADR
- UN 1325
- WGK Germany
- 3
- RTECS
- DI4368500
- Hazard Note
- Toxic
- TSCA
- T
- HazardClass
- 4.1
- PackingGroup
- Ⅱ
- HS Code
- 29269095
- Toxicity
- mouse,LD50,intraperitoneal,1gm/kg (1000mg/kg),Farmaco, Edizione Scientifica. Vol. 41, Pg. 41, 1986.
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H228Flammable solid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 139416
- Product name
- 4-Fluorobenzonitrile
- Purity
- 99%
- Packaging
- 5g
- Price
- $53
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 139416
- Product name
- 4-Fluorobenzonitrile
- Purity
- 99%
- Packaging
- 25g
- Price
- $60.1
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0221
- Product name
- 4-Fluorobenzonitrile
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $28
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0221
- Product name
- 4-Fluorobenzonitrile
- Purity
- >99.0%(GC)
- Packaging
- 100g
- Price
- $60
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0221
- Product name
- 4-Fluorobenzonitrile
- Purity
- >99.0%(GC)
- Packaging
- 500g
- Price
- $243
- Updated
- 2025/07/31
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4-Fluorobenzonitrile Chemical Properties,Usage,Production
Chemical Properties
white crystalline low melting solid
Uses
4-Fluorobenzonitrile is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.
Uses
4-Fluorobenzonitrile is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.
Definition
ChEBI: 4-Fluorobenzonitrile is a member of benzenes and a nitrile.
Application
The application of 4-Fluorobenzonitrile in medicinal chemistry has proven valuable, particularly in the design of novel drug candidates that target specific biological pathways. Additionally, 4-Fluorobenzonitrile is employed in the production of dyes and pigments, offering vibrant colors and improved performance in various formulations.
General Description
4-Fluorobenzonitrile undergoes metal-mediated coupling to yield eight-membered thorium(IV) tetraazamacrocycle. It undergoes condensation with diphenylamine to yield monomer 4-cyanotriphenylamine.
Synthesis
4-Fluorobenzonitrile is synthesised using 4-Fluorobenzyl alcohol as raw material by chemical reaction. The specific synthesis steps are as follows:
With respect to 2 mmol of each alcohol represented by the general formula (1), 4 ml of CH2Cl2 as a solvent, 0.05 equivalent of TEMPO as an N-nitrosyl compound, (A) t-BuOCl, (B) I 2 or (C ) N, N'-diiodo-5,5-dimethylhydantoin (DIH) were mixed in a predetermined amount and stirred for a predetermined time at room temperature.Next, 1.5 equivalents of I 2 and 4 ml of aqueous ammonia were added, and the mixture was stirred at room temperature for 2 hours.
Toxics Screening Level
The screening level is calculated assuming the mouse LD50 was 300 mg/kg and use of the equation from R232(1)(h), as follows. The initial threshold screening level (ITSL) for 4-Fiuorobenzonitrile is 0.5 μg/m3 annual averaging time.
4-Fluorobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluorobenzonitrile manufacturers
Shandong Vital Biotechnology Co., Ltd.
- Product
- 4-Fluorobenzonitrile 1194-02-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100tons
- Release date
- 2025-11-20
HebeiShuoshengImportandExportco.,Ltd
- Product
- 4-Fluorobenzonitrile 1194-02-1
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-08-05
Hebei Longbang Technology Co., Ltd
- Product
- 4-Fluorobenzonitrile 1194-02-1
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- More than 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-05-24
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