4,6-Dimethyl-2-methylsulfonylpyrimidine

Product Name: 4,6-Dimethyl-2-methylsulfonylpyrimidine
CAS No.: 35144-22-0
Chemical Name: 4,6-Dimethyl-2-methylsulfonylpyrimidine
Synonyms: DLMSP;VITAS-BB TBB000242;4,6-Dimethyl-2-methy;Ambrisentan Impurity 6;4,6-Dimethyl-2-(methylsulfonyl;4,6-dimethyl-2-mesyl-pyrimidine;6-DiMethyl-2-MethylsulfonylpyriMidine;4,6-DIMETHY-2-METHYLSULFONYLPYRIMIDINE;4,6-diMethyl-2-Methylsulfonyl pyridine;4,6-DIMETHYL-2-METHYLSULFONYLPYRIMIDINE
CBNumber: CB5202360
Molecular Formula: C7H10N2O2S
Formula Weight: 186.23
MOL File: 35144-22-0.mol

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4,6-Dimethyl-2-methylsulfonylpyrimidine Property

Melting point:: 84-86°C
Boiling point:: 358.3±45.0 °C(Predicted)
Density: 1.239
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: -1.84±0.30(Predicted)
form: Crystalline Solid
color: Red-brown
InChIKey: ZHPSNGCLCHWTRG-UHFFFAOYSA-N
CAS DataBase Reference: 35144-22-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3699
Product name: 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $68
Updated: 2025/07/31

TCI Chemical

Product number: D3699
Product name: 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $269
Updated: 2025/07/31

TRC

Product number: D446930
Product name: 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine
Packaging: 1g
Price: $110
Updated: 2021/12/16

Matrix Scientific

Product number: 031256
Product name: 4,6-Dimethyl-2-methylsulfonylpyrimidine
Purity: 98%
Packaging: 25g
Price: $39
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK195451
Product name: 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine
Purity: 98%
Packaging: 5g
Price: $51
Updated: 2021/12/16

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4,6-Dimethyl-2-methylsulfonylpyrimidine Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

4,6-Dimethyl-2-(methylsulfonyl)pyrimidine is a reactant used in the preparation of [(dimethylpyrimidinyl)oxy]diphenyl butyric acid derivatives as endothelin receptor antagonists.

Synthesis

14001-64-0

35144-22-0

General procedure for the synthesis of 2-methylsulfonyl-4,6-dimethylpyrimidines from 4,6-dimethyl-2-methylthiopyrimidines: 15.9 g (103 mmol) of 4,6-dimethyl-2-methylthiopyrimidines was dissolved in a solvent mixture of 120 mL of dichloromethane and 110 mL of water. Chlorine gas was passed through at 0 °C until the solution took on a yellow color and saturated. Upon completion of the reaction, the solution was purged with nitrogen to remove excess chlorine gas. The organic phase was separated and the aqueous phase was extracted with dichloromethane. The organic phases were combined and dried over anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure and the product was crystallized by the addition of ether to give 14 g (73% yield) of 2-methylsulfonyl-4,6-dimethylpyrimidine. The melting point of the product was 79-80 °C. 1H-NMR (270 MHz, CDCl3): δ 7.2 (1H, s), 3.4 (3H, s), 2.6 (6H, s).

References

[1] Patent: US6670367, 2003, B1. Location in patent: Page column 15-16
[2] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 9, p. 2288 - 2300
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 11, p. 2776 - 2795

4,6-Dimethyl-2-methylsulfonylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

4,6-DIMETHOXYPYRIMIDINE-2-SULFONYL CHLORIDE

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View Lastest Price from 4,6-Dimethyl-2-methylsulfonylpyrimidine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 4,6-Dimethyl-2-methylsulfonylpyrimidine 35144-22-0
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-12

Moxin Chemicals

Product: Ambrisentan Impurity 6 35144-22-0
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 100000
Release date: 2025-03-28

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4,6-Dimethyl-2-methylsulfonylpyrimidine 35144-22-0
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

35144-22-0, 4,6-Dimethyl-2-methylsulfonylpyrimidineRelated Search:

ETHANE Dimethyl phthalate N,N-Dimethylformamide Dimethyl fumarate Dimethyl sulfide Dimethyl sulfoxide Pyrimidine Dimethyl ether 2-Methylsulfonyl-4,6-dimethoxypyrimidine 2-Amino-4,6-dimethylpyrimidine Methanesulfonyl chloride 4,6-DIMETHYL-2-METHYLSULFONYLPYRIMIDINE, 98+% 4,6-DIMETHYLPYRIMIDINE 4,6-Dichloropyrimidine 3-(4-THIOPHEN-2-YL-6-TRIFLUOROMETHYL-PYRIMIDINE-2-SULFONYL)-PROPIONIC ACID 4-[4-(2-METHOXY-PHENYL)-6-TRIFLUOROMETHYL-PYRIMIDINE-2-SULFONYL]-BUTYRIC ACID 4,6-Dimethyl-2-methylsulfonylpyrimidine 4-(4-THIOPHEN-2-YL-6-TRIFLUOROMETHYL-PYRIMIDINE-2-SULFONYL)-BUTYRYL CHLORIDE

VITAS-BB TBB000242

DLMSP

4,6-DIMETHYL-2-METHYLSULFONYLPYRIMIDINE

4,6-DIMETHY-2-METHYLSULFONYLPYRIMIDINE

2-METHANESULFONYL-4,6-DIMETHYL-PYRIMIDINE

4,6-dimethyl-2-mesyl-pyrimidine

4,6-Dimethyl-2-methylsilfonylpyrimidine

4,6-Dimethyl-2-(methylsulfonyl

4,6-DIMETHYL-2-METHYLSULFONYLPYRIMIDINE 99%

2-(Methylsulfonyl)-4,6-dimethylpyrimidine

Pyrimidine,4,6-dimethyl-2-(methylsulfonyl)-

2-Methanesulfonyl-4,6-dimethyl-pyrimidine ,99%

4,6-Dimethyl-2-methy

6-DiMethyl-2-MethylsulfonylpyriMidine

4,6-Dimethyl-2-(methylsulphonyl)pyrimidine

4,6-diMethyl-2-Methylsulfonyl pyridine

Ambrisentan Impurity 6

4,6-Dimethyl-2-(methylsulfonyl)pyrimidine&gt

4,6-Dimethyl-2-methylsulfonylpyrimidine ISO 9001：2015 REACH

4,6-Dimethyl-2-methylsulfonylpyrimidine 35144-22-0

35144-22-0

Intermediate

Heterocycle-Pyrimidine series

Drug Intermediates

Pyrimidines

Boron, Nitrile, Thio,& TM-Cpds

Heterocycles

bc0001