ChemicalBook > CAS DataBase List > Ethyl 4-methoxycinnamate
Ethyl 4-methoxycinnamate
- Product Name
- Ethyl 4-methoxycinnamate
- CAS No.
- 24393-56-4
- Chemical Name
- Ethyl 4-methoxycinnamate
- Synonyms
- ETHYL P-METHOXYCINNAMATE;4-METHOXYCINNAMIC ACID ETHYL ESTER;Ethyl trans-4-methoxycinnamate;(E)-Ethyl p-methoxycinnamate;ethyl (E)-4-methoxycinnamate;ETHYL 3-(4-METHOXYPHENYL)ACRYLATE;EPMC;RARECHEM AL BI 0241;Ethyl 4-Methoxyciamate;Ethyl 4-methoxycinmate
- CBNumber
- CB5205790
- Molecular Formula
- C12H14O3
- Formula Weight
- 206.24
- MOL File
- 24393-56-4.mol
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Ethyl 4-methoxycinnamate Property
- Melting point:
- 49°C
- Boiling point:
- 187 °C / 15mmHg
- Density
- 1.080±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- color
- Off-White
- Water Solubility
- insoluble in water
- BRN
- 2210033
- LogP
- 2.650 (est)
- NIST Chemistry Reference
- Ethyl p-methoxycinnamate(24393-56-4)
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Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-24/25
- WGK Germany
- 3
- HS Code
- 29189900
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 42479
- Product name
- Ethyl trans-4-methoxycinnamate
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $207
- Updated
- 2022/05/15
TCI Chemical
- Product number
- M1204
- Product name
- Ethyl 4-Methoxycinnamate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $80
- Updated
- 2024/03/01
TCI Chemical
- Product number
- M1204
- Product name
- Ethyl 4-Methoxycinnamate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $228
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 11740
- Product name
- Ethyl p-methoxycinnamate
- Packaging
- 50mg
- Price
- $31
- Updated
- 2023/06/20
Cayman Chemical
- Product number
- 11740
- Product name
- Ethyl p-methoxycinnamate
- Packaging
- 100mg
- Price
- $55
- Updated
- 2023/06/20
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Ethyl 4-methoxycinnamate Chemical Properties,Usage,Production
Chemical Properties
White crystalline, soluble in methanol, ethanol, DMSO and other organic solvents, derived from cinnamon.
Uses
Ethyl 4-methoxycinnamate is an derivative of 4-methoxycinnamic acid, an antihyperglycemic/hypoglycemic agent that works by stimulating insulin secretion from pancreas and could be developed into a new potential for therapeutic agent used in type 2 diabetic patients.
Preparation
Ethyl 4-methoxycinnamate synthesis: 4-Methoxycinnamic Acid (0.60 g, 3.36 mmol) was dissolved in 10 mL of dry N,N-dimethylformamide (DMF) in a 25-mL, roundbottomed flask. Cesium carbonate (1.65 g, 5.06 mmol) was added followed by iodoethane (1.0 mL, 12.5 mmol). The flask was capped (rubber septum) and the heterogeneous mixture stirred vigorously at 50 °C for one hour. After this time, HCl (1.0 M, 4.0 mL) was added to quench the reaction. The liquid was decanted from any remaining solid and extracted with 3 : 1 hexanes/ethyl acetate (2 x 10 mL). The organic layer was washed with brine (20 mL), dried with MgSO4, filtered, and solvent removed. The remaining oil solidified on standing to form colorless prisms.
Synthesis of ethyl 4-methoxycinnamate
General Description
Ethyl p-methoxycinnamate (EPMC) is a natural product found in K. galanga and C. zedoaria extracts with anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities. It inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively) and reduces IL-1 and TNF-α production in vivo. EPMC inhibits granuloma tissue formation and acts as an analgesic, delaying tail flick time, in a dose-dependent manner in rats. It inhibits blood vessel growth in rat aortic explants (IC50 = 91.9 μg/ml). EPMC (<10 μg/ml) also reduces growth of T. rubrum, A. niger, S. cerevisiae, and E. floccosum and is larvicidal (LC50 = 53.64 ppm) against Ae. aegypti.
Ethyl 4-methoxycinnamate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 4-methoxycinnamate manufacturers
Hebei Yime New Material Technology Co., Ltd.
- Product
- Ethyl 4-Methoxycinnamate 24393-56-4
- Price
- US $150.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2022-01-22
Hebei Yanxi Chemical Co., Ltd.
- Product
- Ethyl 4-methoxycinnamate 24393-56-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-11-13
Hebei Kingfiner Technology Development Co.Ltd
- Product
- Ethyl 4-methoxycinnamate 24393-56-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000kg
- Release date
- 2023-11-23
24393-56-4, Ethyl 4-methoxycinnamateRelated Search:
Ethylparaben
Ethanol
Ethyl formate
Ethyl acetate
3,4-Dimethoxycinnamonitrile
Ethyl cinnamate
ISOXADIFEN-ETHYL
Ethyl 4-methylcinnamate
4-(Trifluoromethyl)cinnamic acid
Ethyl 4-methoxybenzoate
Ethyl acrylate
Ethyl oleate
Acrylic acid
4-Bromocinnamic acid
4-Methoxycinnamic acid
Octyl 4-methoxycinnamate
Ethyl pyruvate
Ethyl cyanoacetate