Ethyl 4-methoxycinnamate
- Product Name
- Ethyl 4-methoxycinnamate
- CAS No.
- 24393-56-4
- Chemical Name
- Ethyl 4-methoxycinnamate
- Synonyms
- ETHYL P-METHOXYCINNAMATE;4-METHOXYCINNAMIC ACID ETHYL ESTER;Ethyl trans-4-methoxycinnamate;(E)-Ethyl p-methoxycinnamate;ethyl (E)-4-methoxycinnamate;ETHYL 3-(4-METHOXYPHENYL)ACRYLATE;EPMC;RARECHEM AL BI 0241;Ethyl 4-Methoxyciamate;Ethyl 4-methoxycinmate
- CBNumber
- CB5205790
- Molecular Formula
- C12H14O3
- Formula Weight
- 206.24
- MOL File
- 24393-56-4.mol
Ethyl 4-methoxycinnamate Property
- Melting point:
- 49°C
- Boiling point:
- 187 °C / 15mmHg
- Density
- 1.080±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White
- Water Solubility
- insoluble in water
- BRN
- 2210033
- LogP
- 2.650 (est)
- NIST Chemistry Reference
- Ethyl p-methoxycinnamate(24393-56-4)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-24/25
- WGK Germany
- 3
- HS Code
- 29189900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 42479
- Product name
- Ethyl trans-4-methoxycinnamate
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $207
- Updated
- 2022/05/15
- Product number
- M1204
- Product name
- Ethyl 4-Methoxycinnamate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $80
- Updated
- 2024/03/01
- Product number
- M1204
- Product name
- Ethyl 4-Methoxycinnamate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $228
- Updated
- 2024/03/01
- Product number
- 11740
- Product name
- Ethyl p-methoxycinnamate
- Packaging
- 50mg
- Price
- $31
- Updated
- 2023/06/20
- Product number
- 11740
- Product name
- Ethyl p-methoxycinnamate
- Packaging
- 100mg
- Price
- $55
- Updated
- 2023/06/20
Ethyl 4-methoxycinnamate Chemical Properties,Usage,Production
Chemical Properties
White crystalline, soluble in methanol, ethanol, DMSO and other organic solvents, derived from cinnamon.
Uses
Ethyl 4-methoxycinnamate is an derivative of 4-methoxycinnamic acid, an antihyperglycemic/hypoglycemic agent that works by stimulating insulin secretion from pancreas and could be developed into a new potential for therapeutic agent used in type 2 diabetic patients.
Preparation
Ethyl 4-methoxycinnamate synthesis: 4-Methoxycinnamic Acid (0.60 g, 3.36 mmol) was dissolved in 10 mL of dry N,N-dimethylformamide (DMF) in a 25-mL, roundbottomed flask. Cesium carbonate (1.65 g, 5.06 mmol) was added followed by iodoethane (1.0 mL, 12.5 mmol). The flask was capped (rubber septum) and the heterogeneous mixture stirred vigorously at 50 °C for one hour. After this time, HCl (1.0 M, 4.0 mL) was added to quench the reaction. The liquid was decanted from any remaining solid and extracted with 3 : 1 hexanes/ethyl acetate (2 x 10 mL). The organic layer was washed with brine (20 mL), dried with MgSO4, filtered, and solvent removed. The remaining oil solidified on standing to form colorless prisms.
Synthesis of ethyl 4-methoxycinnamate
General Description
Ethyl p-methoxycinnamate (EPMC) is a natural product found in K. galanga and C. zedoaria extracts with anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities. It inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively) and reduces IL-1 and TNF-α production in vivo. EPMC inhibits granuloma tissue formation and acts as an analgesic, delaying tail flick time, in a dose-dependent manner in rats. It inhibits blood vessel growth in rat aortic explants (IC50 = 91.9 μg/ml). EPMC (<10 μg/ml) also reduces growth of T. rubrum, A. niger, S. cerevisiae, and E. floccosum and is larvicidal (LC50 = 53.64 ppm) against Ae. aegypti.
Ethyl 4-methoxycinnamate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 4-methoxycinnamate manufacturers
- Product
- Ethyl 4-methoxycinnamate 24393-56-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-11-13
- Product
- Ethyl 4-methoxycinnamate 24393-56-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000kg
- Release date
- 2023-11-23
- Product
- Ethyl 4-Methoxycinnamate 24393-56-4
- Price
- US $150.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2022-01-22