Medetomidine hydrochloride
- Product Name
- Medetomidine hydrochloride
- CAS No.
- 86347-15-1
- Chemical Name
- Medetomidine hydrochloride
- Synonyms
- MEDETOMIDINE HYDROCHLORIDE;edetomidine;(R)-4-[1-(2;medeomidine hcl;Metetomidine HCl;Medetomidine HCI;Medetomidine HCl Powder;Ethyl Acetate Impurity 85;Medetomidine HCl (MPV-785);Metoclopramide (metoclopramide)
- CBNumber
- CB52130917
- Molecular Formula
- C13H17ClN2
- Formula Weight
- 236.74
- MOL File
- 86347-15-1.mol
Medetomidine hydrochloride Property
- Melting point:
- 164-166°C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Acetonitrile (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- biological source
- synthetic
- InChI
- InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H
- InChIKey
- VPNGEIHDPSLNMU-UHFFFAOYSA-N
- SMILES
- C(C1N=CNC=1)(C1C=CC=C(C)C=1C)C.Cl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M3314
- Product name
- Medetomidine Hydrochloride
- Packaging
- 25MG
- Price
- $20
- Updated
- 2025/07/31
- Product number
- M3314
- Product name
- Medetomidine Hydrochloride
- Packaging
- 100MG
- Price
- $49
- Updated
- 2025/07/31
- Product number
- 16454
- Product name
- Medetomidine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 16454
- Product name
- Medetomidine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 16454
- Product name
- Medetomidine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $388
- Updated
- 2024/03/01
Medetomidine hydrochloride Chemical Properties,Usage,Production
Description
Medetomidine hydrochloride is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). It is an imidazole compound. Medetomidine hydrochloride shows greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). In addition, it influences the adrenergic system by mimicking the action of adrenergic neurotransmitters.
Chemical Properties
White Solid
Uses
Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor
Uses
An α2-Adrenergic agonist. Sedative; analgesic.
Definition
ChEBI: Medetomidine hydrochloride is a hydrochloride.
Indications
Medetomidine hydrochloride is an FDA-approved alpha2-adrenoceptor (α2-AR) agonist with analgesic, sedative and anxiolytic properties for use as a veterinary sedative. It has been approved for use in animals such as cats, sheep, and dogs (12 weeks of age and older.) In 1999, the FDA approved Medetomidine for human use in the sedation of intubated and mechanically ventilated intensive care unit (ICU) patients, including use as a pain reliever and for use in non-intubated patients prior to and during surgery and other procedures. In addition to its pharmaceutical uses, it is used as an antifouling agent in marine coatings.[1]
Biological Activity
medetomidine is a selective α2-adrenoceptor agonist, with ki of 1.08 nm, exhibts 1620-fold selectivity over α1-adrenoceptor.
Pharmacokinetics
After intramuscular injection, medetomidine is rapidly and almost completely absorbed at the site of injection and its pharmacokinetics are very similar to that observed after intravenous injection. Maximum plasma concentrations are reached within 15 to 20 minutes. Estimated plasma half-life is 1.2 hours for dogs and 1.5 hours for cats. Medetomidine is mainly oxidised in the liver, while a small amount is methylated in the kidney. Metabolites are primarily excreted in urine.
Side effects
Medetomidine hydrochloride is an alpha-2 adrenoreceptor agonist. Symptoms after absorption may involve clinical effects, including dose dependent sedation, respiratory depression, bradycardia, hypotension, a dry mouth, and hyperglycaemia. Ventricular arrhythmias have also been reported. Respiratory and haemodynamic symptoms should be treated symptomatically.
Synthesis
Medetomidine hydrochloride is synthesized using 2,3-Dimethylbromobenzene as the starting material through a series of Grignard reactions. This process yields tertiary alcohol 7, which is subsequently subjected to dehydration and hydrogenation. The overall yield achieved was 17 percent.[1] The reaction scheme is illustrated as follows:
Additional synthetic processes encompass:
storage
Desiccate at RT
References
[1] PEDRO DE ANDRADE HORN. Classics in Chemical Neuroscience: Medetomidine.[J]. ACS Chemical Neuroscience, 2024: 3874-3883. DOI:10.1021/acschemneuro.4c00583.
Medetomidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Medetomidine hydrochloride Suppliers
- Tel
- 18949937116
- dongye.huaxue@126.com
- Country
- China
- ProdList
- 145
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6003
- Advantage
- 61
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 86-0571-85151182
- Fax
- 86-0571-85151182
- Country
- China
- ProdList
- 5691
- Advantage
- 66
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- 0531-0531-58897003 15550412551
- Fax
- 0531-58897003
- market@jnchsd.com
- Country
- China
- ProdList
- 229
- Advantage
- 62
- Tel
- 0871-65217109 13211707573;
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 5653
- Advantage
- 65
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 021-33632979
- Fax
- 021-34692979
- info@tsbiochem.com
- Country
- China
- ProdList
- 8065
- Advantage
- 58
- Tel
- 15722085254
- Fax
- 022-26358246
- phytochemical@126.com
- Country
- China
- ProdList
- 813
- Advantage
- 55
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9637
- Advantage
- 58
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 21-619849051-1 18521059765
- synchempharma@aliyun.com
- Country
- China
- ProdList
- 6468
- Advantage
- 55
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 6687
- Advantage
- 55
- Tel
- 025-87193546 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 9021
- Advantage
- 60
- Tel
- +86 (531) 8099-2215
- Fax
- +86 (531) 8099-2215
- putubio@outlook.com
- Country
- China
- ProdList
- 1261
- Advantage
- 55
- Tel
- 0571-87157530-8008 17369838938
- Fax
- 0571-87156470
- sales@dingyanchem.com
- Country
- China
- ProdList
- 2386
- Advantage
- 58
- Tel
- 526763801 13301653310
- Fax
- +86-21-51619052
- 526763801@qq.com
- Country
- China
- ProdList
- 9274
- Advantage
- 55
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3866
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9923
- Advantage
- 55
- Tel
- 025-83453382-8005
- Fax
- 025-83453382
- sale@parabiochem.com
- Country
- China
- ProdList
- 9595
- Advantage
- 55
- Tel
- sales@njromanme.com
- Country
- China
- ProdList
- 4529
- Advantage
- 58
- Tel
- 18511709189
- Fax
- 010-58043593
- sales@hechemist.com
- Country
- China
- ProdList
- 2835
- Advantage
- 58
- Tel
- 400-1166-196 15982826727
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 14603
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 18029243487 2355327168
- Fax
- 020-31121510
- gy@yccreate.com
- Country
- China
- ProdList
- 4749
- Advantage
- 55
- Tel
- 027-027-83778875 15807197853
- Fax
- 027-83991220
- 15807197853@163.com
- Country
- China
- ProdList
- 3931
- Advantage
- 58
- Tel
- 0755-0755-28967200-8062 13631290199
- Fax
- 0755-28967200
- wxf@sungening.com
- Country
- China
- ProdList
- 9624
- Advantage
- 60
- Tel
- 0531-82956131 15069164249
- Fax
- 0531-82956625
- jnjspharm@126.com
- Country
- China
- ProdList
- 1518
- Advantage
- 55
- Tel
- +86-21-5877 1921
- Fax
- +86-21-5877 1925
- info@chemofchina.com
- Country
- China
- ProdList
- 9653
- Advantage
- 55
- Tel
- 531-58897070 15254140813
- Fax
- 0531-58897046
- market@jnchsd.com
- Country
- China
- ProdList
- 235
- Advantage
- 58
- Tel
- 13715524166 13326948089
- Fax
- +86 760 8866 5202
- resicn@resicn.com
- Country
- China
- ProdList
- 520
- Advantage
- 58
- Tel
- 18578209868 2355327026
- Fax
- 18578209868 QQ：2355327026
- steroidbest@hotmail.com
- Country
- China
- ProdList
- 6501
- Advantage
- 58
- Tel
- 021-16621358918; 18516310516
- Fax
- 13045646768
- zhenlipharma888@163.com
- Country
- China
- ProdList
- 19035
- Advantage
- 58
- Tel
- 0755-89880280
- Fax
- 0755-89880280
- 3004662104@qq.com
- Country
- China
- ProdList
- 1829
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
View Lastest Price from Medetomidine hydrochloride manufacturers
- Product
- Metetomidine HCl 86347-15-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-31
- Product
- 5-[1-(2,3-diMethylphenyl)ethyl]-1H-IMidazole hydrochloride 86347-15-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-31
- Product
- Medetomidine hydrochloride 86347-15-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-08