Ganoderenic acid D

Product Name: Ganoderenic acid D
CAS No.: 100665-43-8
Chemical Name: Ganoderenic acid D
Synonyms: Ganoderenic acid d;Apoptosis,Inhibitor,inhibit,Ganoderenic acid D;(20E)-7β-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-diene-26-oic acid;(20E)-7β-Hydroxy-3,11,15,23-tetraoxo-5α-lanosta-8,20(22)-dien-26-oic acid;(7beta,20E)-7-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-dien-26-oic acid;Lanosta-8,20(22)-dien-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β,20E)-;(E)-6-((5R,7S,10S,13R,14R,17R)-7-Hydroxy-4,4,10,13,14-pentamethyl-3,11,15-trioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-4-oxohept-5-enoic acid
CBNumber: CB52192797
Molecular Formula: C30H40O7
Formula Weight: 512.6344
MOL File: 100665-43-8.mol

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Ganoderenic acid D Property

Melting point:: 218-220℃
Boiling point:: 702.3±60.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 4.63±0.23(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 300301
Product name: Ganoderenic acid D
Packaging: 10mg
Price: $490
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259246
Product name: Ganoderenic acid D
Purity: 98%
Packaging: 5mg
Price: $654.5
Updated: 2021/12/16

AvaChem

Product number: 3481
Product name: Ganoderenic acid D
Packaging: 10mg
Price: $590
Updated: 2021/12/16

AvaChem

Product number: 3481
Product name: Ganoderenic acid D
Packaging: 2mg
Price: $249
Updated: 2021/12/16

Arctom

Product number: CFN90300
Product name: GanoderenicacidD
Purity: ≥98%
Packaging: 10mg
Price: $476
Updated: 2021/12/16

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Ganoderenic acid D Chemical Properties,Usage,Production

Uses

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. It inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells. It also induces HeLa human cervical carcinoma apoptosis.

Definition

ChEBI: Ganoderenic acid D is a triterpenoid.

Biological Activity

Ganoderenic acid D is a triterpenoid originally isolated from G. lucidum and has diverse biological activities. It inhibits angiotensin-converting enzyme (ACE; IC50 = 734 μM). Ganoderenic acid D is cytotoxic to HepG2 liver, HeLa cervical, and Caco-2 colon cancer cells (IC50s = 0.14, 0.18, and 0.26 mg/ml, respectively). It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50 = 13.77 μM).

Ganoderenic acid D Preparation Products And Raw materials

Raw materials

Preparation Products

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Ganoderenic acid D Suppliers

China 90 United Kingdom 1 United States 9 USA 1 Global 101

ALB Technology Limited

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EMMX Biotechnology LLC

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TargetMol Chemicals Inc.

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BOC Sciences

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Aladdin Scientific

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TargetMol Chemicals Inc.

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MedChemExpress

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View Lastest Price from Ganoderenic acid D manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Ganoderenic acid D 100665-43-8
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-04-13

Career Henan Chemical Co

Product: Ganoderenic acid D 100665-43-8
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg , 5kg, 50kg
Release date: 2020-01-17

100665-43-8, Ganoderenic acid DRelated Search:

LUCIDENIC ACID D2(SH) (5alpha,7beta)-7-Hydroxy-4,4,14-trimethyl-3,11,15-trioxo-chola-8,20-dien-24-oic acid Lucidenic acid L 23S-hydroxyl-11,15-dioxo-ganoderic acid DM Lucidenic acid B Lucidenic acid C Ganoderenic acid E VIGABATRIN ECHINOCYSTIC ACID Epmedin B ASARININ MOLLUGIN Paederosidic acid Jujuboside B Astragaloside II Ganoderenic acid B (20E)-3β,7β,15α-Trihydroxy-11,23-dioxo-5α-lanosta-8,20(22)-dien-26-oic acid ganoderenic acid A

(20E)-7β-Hydroxy-3,11,15,23-tetraoxo-5α-lanosta-8,20(22)-dien-26-oic acid

(20E)-7β-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-diene-26-oic acid

(7beta,20E)-7-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-dien-26-oic acid

Ganoderenic acid d

Apoptosis,Inhibitor,inhibit,Ganoderenic acid D

(E)-6-((5R,7S,10S,13R,14R,17R)-7-Hydroxy-4,4,10,13,14-pentamethyl-3,11,15-trioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-4-oxohept-5-enoic acid

Lanosta-8,20(22)-dien-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β,20E)-

100665-43-8

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract