ChemicalBook > CAS DataBase List > N-Boc-cadaverine

N-Boc-cadaverine

Product Name: N-Boc-cadaverine
CAS No.: 51644-96-3
Chemical Name: N-Boc-cadaverine
Synonyms: N-BOC-1,5-DIAMINOPENTANE;TERT-BUTYL N-(5-AMINOAMYL)CARBAMATE;BOC-DAPE-OH;BOC-DAPE HCL;N-Boc-cadaverine;PROTAC Linker 23;Boc-DAPe-OH, liq.;Boc-NH-(CH2)5-NH2;BOC-NH(CH2)5NH2 HCL;BOC-1,5-DIAMINOPENTANE
CBNumber: CB5222821
Molecular Formula: C10H22N2O2
Formula Weight: 202.29
MOL File: 51644-96-3.mol

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N-Boc-cadaverine Property

Boiling point:: 309.2±25.0 °C(Predicted)
Density: 0.972 g/mL at 20 °C(lit.)
refractive index: n20/D 1.460
Flash point:: 109 °C
storage temp.: Keep in dark place,Sealed in dry,2-8°C
pka: 12.91±0.46(Predicted)
form: Oil
color: Yellow
BRN: 3603658
InChI: InChI=1S/C10H22N2O2/c1-10(2,3)14-9(13)12-8-6-4-5-7-11/h4-8,11H2,1-3H3,(H,12,13)
InChIKey: DPLOGSUBQDREOU-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCCCCCN
CAS DataBase Reference: 51644-96-3(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-36/37/39-45
RIDADR: UN 2735 8/PG 3
WGK Germany: 3
F: 10-34
HazardClass: 8
PackingGroup: Ⅲ
HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15406
Product name: N-Boc-cadaverine
Purity: ≥97.0% (NT)
Packaging: 1ml
Price: $114.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15406
Product name: N-Boc-cadaverine
Purity: 97%
Packaging: 5ml
Price: $586
Updated: 2025/07/31

TCI Chemical

Product number: A1374
Product name: N-(tert-Butoxycarbonyl)-1,5-diaminopentane
Purity: >98.0%(T)
Packaging: 1g
Price: $141
Updated: 2025/07/31

TCI Chemical

Product number: A1374
Product name: N-(tert-Butoxycarbonyl)-1,5-diaminopentane
Purity: >98.0%(T)
Packaging: 5g
Price: $451
Updated: 2025/07/31

Usbiological

Product number: 265594
Product name: Boc-1,5-diaminopentane
Packaging: 1g
Price: $356
Updated: 2021/12/16

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N-Boc-cadaverine Chemical Properties,Usage,Production

Description

tert-Butyl (5-aminopentyl)carbamate can be used as a PROTAC linker in the synthesis of PROTACs. tert-Butyl (5-aminopentyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

Some of the reported applications of N-Boc-cadaverine include:

Synthesis of of a supermacrocycle that self-assemble to form organic nanotubes.
Preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye.
Synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).

Uses

N-Boc-cadaverine is an intermediate in the synthesis of derivative of the folic acid antagonist Methotrexate (M260675) used in the study of membrane-associated folate transporters from L1210 cells.

reaction suitability

reagent type: cross-linking reagent

Synthesis

462-94-2

24424-99-5

51644-96-3

GENERAL PROCEDURE: A solution of di-tert-butyl dicarbonate (22 g, 100 mmol) was prepared by dissolving it in methanol (20 mL) under ice bath cooling conditions. This solution was slowly added dropwise over 30 minutes to a stirred methanol solution (160 mL) of 1,5-diaminopentane (1.8 g, 20 mmol). After the dropwise addition was completed, the ice bath was removed and the reaction mixture was allowed to continue stirring at room temperature for 4 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography with the eluent ratio of chloroform:methanol:ammonia = 10:1:0.1 to give tert-butyl N-(5-aminopentyl)carbamate in 83% yield.

IC 50

Alkyl-Chain

References

[1] European Journal of Organic Chemistry, 1998, # 5, p. 853 - 859
[2] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 6, p. 614 - 617
[3] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 20, p. 7145 - 7155
[4] Journal of Medicinal Chemistry, 2004, vol. 47, # 20, p. 4933 - 4940
[5] Chemical and Pharmaceutical Bulletin, 2015, vol. 63, # 5, p. 326 - 333

N-Boc-cadaverine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-cadaverine Suppliers

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View Lastest Price from N-Boc-cadaverine manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: N-Boc-cadaverine 51644-96-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 97%
Supply Ability: 1000kg
Release date: 2025-10-23

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-Boc-cadaverine 51644-96-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: N-Boc-cadaverine 51644-96-3
Price: US $3500.00/KG
Min. Order: 1G
Purity: 95%
Supply Ability: 100kg
Release date: 2018-08-03

51644-96-3, N-Boc-cadaverineRelated Search:

4-(tert-ButoxycarbonylaMino)-1-butanol N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate N,N'-Disuccinimidyl carbonate 1,3-DI-BOC-2-METHYLISOTHIOUREA Carbamic acid, (4-amino-2-butynyl)-, 1,1-dimethylethyl ester (9CI) Carbamic acid, (tetrahydro-4-oxo-2H-pyran-3-yl)-, 1,1-dimethylethyl ester (9CI) tert-butyl N-(4,4-dimethyl-3-oxopentyl)-N-methylcarbamate tert-butyl N-(4-hydroxy-3-methylcyclohexyl)carbamate tert-butyl N-(5-aminonaphthalen-1-yl)carbamate tert-butyl N-(5-{[(tert-butoxy)carbonyl]amino}-3-oxopentyl)c arbamate N,N'-Di-Boc-L-lysine hydroxysuccinimide ester Boc-Lys-OH Ne-Boc-L-lysine tert-butyl ester hydrochloride H-Lys(Boc)-OH BOC-HOARG-OH BOC-LYS(TFA)-OH N-Boc-N'-(2-chlorobenzyloxycarbonyl)-L-lysine BOC-LYS(BOC)-OH DCHA

TERT-BUTYL N-(5-AMINOAMYL)CARBAMATE

TERT-BUTYL N-(5-AMINOPENTYL)CARBAMATE

N-TERT-BUTYLOXYCARBONYL-1,5-DIAMINOPENTANE HYDROCHLORIDE

N-(TERT-BUTOXYCARBONYL)-1,5-DIAMINOPENTANE

N-(TERT-BUTOXYCARBONYL)-1,5-PENTANEDIAMINE

N-T-BUTYLOXYCARBONYL-1,5-DIAMINOPENTANE HYDROCHLORIDE

N-BOC-1,5-DIAMINOPENTANE

N-BOC-1,5-PENTANEDIAMINE

N-(5-AMINOAMYL)CARBAMIC ACID TERT-BUTYL ESTER

N-(5-AMINOPENTYL)CARBAMIC ACID TERT-BUTYL ESTER

N-1-T-BUTOXYCARBONYL-1,5-DIAMINOPENTANE HYDROCHLORIDE

N-1-BOC-1,5-DIAMINOPENTANE HCL

BOC-1,5-DIAMINOPENTANE

BOC-1,5-DIAMINOPENTANE HCL

BOC-1,5-DIAMINOPENTANE HYDROCHLORIDE

BOC-DIAMINOPENTANE HCL

BOC-DAPE HCL

BOC-DAPE-OH

BOC-NH(CH2)5NH2 HCL

TERT-BUTYL N-(2-AMINOPENTYL)CARBAMATE

N-Boc-cadaverine

1-BOC-AMINO-1,5-PENTANEDIAMINE

5-tert-butoxycarbonylamino-1-aminopentane

N-t-Butyloxycarbonyl-1,5-diaminopentane, N-Boc-cadaverine hydrochloride

Boc-DAPe-OH, liq.

N-Boc-1,5-diaminopentane, tert-Butyl N-(5-aminopentyl)carbamate

N-(5-Aminoamyl)carbamic Acid tert-Butyl Ester N-(5-Aminopentyl)carbamic Acid tert-Butyl Ester N-Boc-1,5-diaminopentane N-(tert-Butoxycarbonyl)-1,5-pentanediamine tert-Butyl N-(5-Aminopentyl)carbamate N-Boc-1,5-pentanediamine

CarbaMic acid, N-(5-aMinopentyl)-, 1,1-diMethylethyl ester

tert-butyl N-(1,5-diaMinopentyl)carbaMate

N-Boc-cadaverine >=97.0% (NT)

N-(tert-Butoxycarbonyl)-1,5-diaminopentane

N1-Boc-1,5-pentanediamine

N-BOC-cadaverine *CAS 51644-96-3*

N-(tert-Butoxycarbonyl)-1,5-diaminopentane &gt

PROTAC Linker 23

NH-2-C5-NH-Boc,inhibit,PROTAC Linkers,PROTAC Linker23,PROTAC Linker-23,NH2C5NHBoc,Inhibitor,NH2 C5 NH Boc

Boc-NH-(CH2)5-NH2

N-Boc-cadaverine

51644-96-3

CH3COCONHCH25NH2

C10H22N2O2HCl

C10H23ClN2O2

Building Blocks

Organic Building Blocks

Nitrogen Compounds

Protected Amines

Monoprotected Diaminoalkanes

N-Boc-diaminoalkanes

Monoprotected Diaminoalkanes

N-Boc-diaminoalkanes

amino acids

pharmacetical