ChemicalBook > CAS DataBase List > 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol

7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol

Product Name: 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol
CAS No.: 39929-79-8
Chemical Name: 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol
Synonyms: Tofacitinib Impurity 188;2,6-Dihydroxy-7-deazapurine;2,4-Dihydroxy-7-deazapurine;4,6-DIHYDROXY PYRROLO PYRIMIDINE;7H-Pyrrolo2,3-dpyrimidin-2,4-diol;7H-Pyrrlo[2,3-d]pyrimidine-2,4-diol;7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol;39929-79-8;2,4-Dihydroxy-1H-pyrrolo[2,3-d]pyrimidine;2,4-Dihydroxy-7H-pyrrolo-(2,3-d)pyrimidine
CBNumber: CB5233427
Molecular Formula: C6H5N3O2
Formula Weight: 151.12
MOL File: 39929-79-8.mol

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7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol Property

Melting point:: >250°C
Density: 1.516±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMF, DMSO (Slightly)
form: Solid
pka: 11.22±0.20(Predicted)
color: Brown to Black
InChI: InChI=1S/C6H5N3O2/c10-5-3-1-2-7-4(3)8-6(11)9-5/h1-2H,(H3,7,8,9,10,11)
InChIKey: HASUWNAFLUMMFI-UHFFFAOYSA-N
SMILES: C1(=O)NC(=O)C2C=CNC=2N1

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Safety

Hazard Codes: Xi
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D454675
Product name: 2,4-Dihydroxypyrrolo[2,3-d]pyrimidine
Packaging: 25g
Price: $740
Updated: 2021/12/16

ChemScene

Product number: CS-D0916
Product name: 1H-Pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione
Purity: 99.72%
Packaging: 25g
Price: $356
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD11329
Product name: 7-Deazaxanthine
Packaging: 10g
Price: $400
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0007925
Product name: 2,4-DIHYDROXY-7H-PYRROLO[2,3-D]PYRIMIDINE
Purity: 95.00%
Packaging: 1G
Price: $708.48
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD11329
Product name: 7-Deazaxanthine
Packaging: 2g
Price: $180
Updated: 2021/12/16

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7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol Chemical Properties,Usage,Production

Chemical Properties

Pink to Brown Solid

Uses

2,4-Dihydroxypyrrolo[2,3-d]pyrimidine (cas# 39929-79-8) is a compound useful in organic synthesis.

Synthesis

107-20-0

873-83-6

39929-79-8

A suspension of 6-aminouracil (6.35 g, 50.0 mmol) and sodium acetate (4.10 g, 50.0 mmol) was formed in 50 mL of water. The reaction system was heated to 72 °C, followed by slow dropwise addition of 50% aqueous chloroacetaldehyde (11.8 g, 75.2 mmol). After the dropwise addition, the reaction temperature was raised to 80 °C and the reaction was continued with stirring for 60 min. Upon completion of the reaction, the mixture was cooled to room temperature and the resulting solid product was collected by filtration. The solid was washed sequentially with water and acetone and subsequently dried under vacuum to afford 2,4-dihydroxypyrrolo[2,3-d]pyrimidine (6.46 g, 86% yield) as a light brown solid. The structure of the product was confirmed by 1H-NMR (400 MHz, DMSO-d6) and mass spectrometry: 1H-NMR δ 11.45 (s, 1H), 11.10 (s, 1H), 10.48 (s, 1H), 6.64-6.51 (m, 1H), 6.22 (t, J = 2.5 Hz, 1H); MS (m/z) [M + H] + 152.06 .

References

[1] Tetrahedron, 2014, vol. 70, # 33, p. 4947 - 4956
[2] Patent: WO2018/137036, 2018, A1. Location in patent: Paragraph 00233; 00234
[3] Synlett, 2005, # 5, p. 744 - 750
[4] Patent: WO2009/37467, 2009, A1. Location in patent: Page/Page column 15-16; 13

7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol manufacturers

Dideu Industries Group Limited

Product: 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol 39929-79-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: 7H-pyrrolo[2,3-d]pyriMidine-2,4-diol 39929-79-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol 39929-79-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

39929-79-8, 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diolRelated Search:

Butylated Hydroxytoluene Chrysin Triclosan 1,3-Dihydroxyacetone 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL DEAZAPURINE 1-Hydroxyethylidene-1,1-diphosphonic acid 3-Diethylaminophenol 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 4-Chloro-5,6-diMethyl-7H-pyrrolo[2,3-d]pyriMidine N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine Tofacitinib Impurity 29 N-Hydroxysuccinimide CYANOACETIC ACID-OSU 1-Benzyl-4-methyl-piperidin-3-one hydrochloride 6-AMINO-5(2,2-DIETHOXYETHYL)-4-HYDROXY-2-MERCAPTOPYRIMIDINE Benzyl chloride 4-(Hydroxyamino)-4-oxobutanoic acid

4-hydroxy-1,5-dihydropyrrolo[3,2-d]pyrimidin-6-one

Tofacitinib Impurity 188

1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidine-2,4(3H)-dione

1H-PYRROLO-[2,3-D]-PYRIMIDINE-2,4(3H,7H)-DIONE

1,7-DIHYDRO-PYRROLO[2,3-D]PYRIMIDINE-2,4-DIONE

2,4-Dihydroxy-1H-pyrrolo[2,3-d]pyrimidine

2,4-Dihydroxy-7-deazapurine

7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol

4,6-DIHYDROXY PYRROLO PYRIMIDINE

2,4-Dihydroxy-7H-pyrrolo-(2,3-d)pyrimidine

2,6-Dihydroxy-7-deazapurine

2,4-Dihydroxy-7H-pyrrolo[2,3-d]pyrimidine, 2,6-Dihydroxy-7-deazapurine

7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol ISO 9001：2015 REACH

7H-Pyrrlo[2,3-d]pyrimidine-2,4-diol

7H-Pyrrolo2,3-dpyrimidin-2,4-diol

1H,2H,3H,4H,7H-pyrrolo[2,3-d]pyrimidine-2,4-dione

7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol 98%

39929-79-8

Heterocycle-Pyrimidine series

Nucleotides and Nucleosides

Bases & Related Reagents

Intermediates

Nucleotides

Fused Ring Systems