3-(Trifluoromethyl)phenylhydrazine hydrochloride
- Product Name
- 3-(Trifluoromethyl)phenylhydrazine hydrochloride
- CAS No.
- 3107-33-3
- Chemical Name
- 3-(Trifluoromethyl)phenylhydrazine hydrochloride
- Synonyms
- 3-Trifloromethylphenylhydrazine;3-TRIFLUOROMETHYL PHENYLHYDRAZINE HCL;3-Hydrazinobenzotrifluoride hydrochloride;3-Trifluoromethylphenylhydrazine hydrochlroide;3-(TRIFLUOROMETHYL)PHENYLHYDRAZINE HYDROCHLORIDE;3-(Triflnoromethyl)phenl hydrazine hydrochloride;N'-(3-TRIFLUOROMETHYL-PHENYL)-HYDRAZINIUM, CHLORIDE;3-(Trifluoromethyl)phenylhydrazine hydrochloride,98%;3107-33-3 3-(Trifluoromethyl)phenylhydrazine hydrochloride;Hydrazine, [3-(trifluoromethyl)phenyl]-, hydrochloride (1:1)
- CBNumber
- CB5236640
- Molecular Formula
- C7H8ClF3N2
- Formula Weight
- 212.6
- MOL File
- 3107-33-3.mol
3-(Trifluoromethyl)phenylhydrazine hydrochloride Property
- Melting point:
- 224-225 °C (decomp)
- Boiling point:
- 140℃/30mm
- Density
- 1.348
- refractive index
- 1.504 (20/D)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO, Methanol
- form
- Solid
- color
- Pale Yellow
- Specific Gravity
- 1.348
- CAS DataBase Reference
- 3107-33-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22
- Safety Statements
- 36/37-24/25
- Hazard Note
- Irritant
- TSCA
- N
- HS Code
- 29280000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 290864
- Product name
- 3-Trifluoromethyl phenylhydrazine HCl
- Packaging
- 5g
- Price
- $369
- Updated
- 2021/12/16
- Product number
- T797095
- Product name
- 3-(Trifluoromethyl)phenylhydrazineHydrochloride
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- T797095
- Product name
- 3-(Trifluoromethyl)phenylhydrazineHydrochloride
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- T797095
- Product name
- 3-(Trifluoromethyl)phenylhydrazineHydrochloride
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 005466
- Product name
- 3-(Trifluoromethyl)phenylhydrazine hydrochloride
- Purity
- 95%
- Packaging
- 25g
- Price
- $49
- Updated
- 2021/12/16
3-(Trifluoromethyl)phenylhydrazine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Off-white powder
Uses
3-Trifluoromethylphenylhydrazine Hydrochloride, is an intermediate in the synthesis of pharmaceutical compounds including inhibitors, and anticancer agents. It is used in the synthesis of isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents.
Synthesis
401-78-5
3107-33-3
General procedure for the synthesis of 3-trifluoromethylphenylhydrazine hydrochloride from m-bromobenzotrifluoride: CuBr (36 mg, 0.25 mmol, 2.5 mol%), ligand L3 (110 mg, 0.4 mmol, 4 mol%), H2O (0.5 mL), and K3PO4 (254 mg, 1.2 mmol) were added and mixed in a 15 mL screw-top capped test tube. STAC (110 mg, 0.3 mmol, 3 mol%) and m-bromobenzotrifluoride (10 mmol) were then added, and the resulting mixture was stirred at 80-110°C (oil bath temperature) for 10 min. Next, K3PO4 (2.29 g, 10.8 mmol) and N2H4-H2O (1 g, 20 mmol) were added and argon gas (flow rate 5-7 mL/min) was bubbled through the reaction mixture for 5 min. The reaction mixture was stirred in a closed test tube at 80-110°C (oil bath temperature) for 1-2 h. The progress of the reaction was monitored by TLC (eluent: hexane) until the feedstock was completely consumed. After completion of the reaction, it was cooled to room temperature and diluted with dichloromethane (50 mL). The resulting solution was filtered and washed with saturated saline (225 mL). A 37% aqueous HCl solution was added dropwise to the dichloromethane solution until the pH reached 3-4. The precipitate formed was filtered, washed with dichloromethane (15 mL) and dried at room temperature. NMR spectra of the partially synthesized 3-trifluoromethylphenylhydrazine hydrochloride showed the presence of 1-5 mol% of the corresponding aniline hydrochloride as an impurity (see Supplementary Data). To obtain an analytically pure sample, it can be purified by precipitation by adding 2-3 volumes of diethyl ether from a methanol solution.
References
[1] Chinese Journal of Chemistry, 2018, vol. 36, # 11, p. 1003 - 1006
[2] Tetrahedron, 2014, vol. 70, # 26, p. 4043 - 4048
3-(Trifluoromethyl)phenylhydrazine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
3-(Trifluoromethyl)phenylhydrazine hydrochloride Suppliers
- Tel
- --
- Fax
- --
- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
- Tel
- --
- Fax
- --
- sales@carbonesci.com
- Country
- United Kingdom
- ProdList
- 6666
- Advantage
- 30
- Tel
- --
- Fax
- --
- sales@melford.co.uk
- Country
- United Kingdom
- ProdList
- 1516
- Advantage
- 64
- Tel
- --
- Fax
- --
- sales@etascientific.com
- Country
- United Kingdom
- ProdList
- 6090
- Advantage
- 34
- Tel
- --
- Fax
- --
- sales@gs-chem.com
- Country
- United Kingdom
- ProdList
- 6098
- Advantage
- 47
- Tel
- --
- Fax
- --
- vernam@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6375
- Advantage
- 65
- Tel
- --
- Fax
- --
- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
- 74
- Tel
- --
- Fax
- --
- info@apinchemicals.com
- Country
- United Kingdom
- ProdList
- 6807
- Advantage
- 42
View Lastest Price from 3-(Trifluoromethyl)phenylhydrazine hydrochloride manufacturers
- Product
- 3-(Trifluoromethyl)phenylhydrazine hydrochloride 3107-33-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-11
- Product
- 3-(Trifluoromethyl)phenylhydrazine hydrochloride 3107-33-3
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-08-20