2-AMINO-BETA-NAPHTHOTHIAZOLE

2-AMINO-BETA-NAPHTHOTHIAZOLE Property

Melting point:

184-188°C

Boiling point:

417.1±28.0 °C(Predicted)

Density 

1.403±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

DMSO: ≥30mg/mL

form 

solid

pka

3.50±0.30(Predicted)

color 

Off-white

Stability:

Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

CAS DataBase Reference

40172-65-4(CAS DataBase Reference)

EPA Substance Registry System

Naphtho[1,2-d]thiazol-2-amine (40172-65-4)

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38-36-22

Safety Statements 

22-36/37/39-26

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

2-AMINO-BETA-NAPHTHOTHIAZOLE Chemical Properties,Usage,Production

Description

SKA-31 (40172-65-4) is a KCa3.1 and KCa2 potassium channel activator (EC50 =260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Enhanced acetylcholine-induced EDHF dilator response in mouse carotid arteries and lowers blood pressure in mouse models at 30 mg/Kg.1,2 Evokes robust vasodilation in rat mesenteric arteries.3

Uses

SKA-31 is a potent potassium channel activator with EC50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively. SKA-31 potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure[1].

Biological Activity

Activator of K Ca 3.1 and K Ca 2 channels (EC 50 values are 260, 2900, 2900 nM for K Ca 3.1, K Ca 2.1 and K Ca 2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.

in vivo

storage

+4°C

References

[1] ANANTHAKRISHNAN SANKARANARAYANAN. Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure.[J]. Molecular Pharmacology, 2009, 75 2: 281-295. DOI:10.1124/mol.108.051425
[2] SEBASTIAN BRÄHLER. Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension.[J]. Circulation, 2009, 119 17: 2323-2332. DOI:10.1161/circulationaha.108.846634
[3] RAYAN KHADDAJ-MALLAT  Andrew P B  Cini Mathew John. SKA-31, an activator of endothelial Ca2+-activated K+ channels evokes robust vasodilation in rat mesenteric arteries[J]. European journal of pharmacology, 2018, 831: Pages 60-67. DOI:10.1016/j.ejphar.2018.05.006