5-CHLOROPYRAZINE-2-CARBALDEHYDE
- Product Name
- 5-CHLOROPYRAZINE-2-CARBALDEHYDE
- CAS No.
- 88625-24-5
- Chemical Name
- 5-CHLOROPYRAZINE-2-CARBALDEHYDE
- Synonyms
- 5-CHLOROPYRAZINE-2-CARBALDEHYDE;5-Chloro-pyrazinecarboxaldehyde;Pyrazinecarboxaldehyde, 5-chloro-;5-Chloropyrazine-2-carboxaldehyde;5-Chloro-2-pyrazinecarboxaldehyde;2-Pyrazinecarboxaldehyde, 5-chloro-
- CBNumber
- CB52454569
- Molecular Formula
- C5H3ClN2O
- Formula Weight
- 142.54
- MOL File
- 88625-24-5.mol
5-CHLOROPYRAZINE-2-CARBALDEHYDE Property
- Boiling point:
- 221℃
- Density
- 1.432
- Flash point:
- 88℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.78±0.10(Predicted)
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- C384323
- Product name
- 5-Chloropyrazine-2-carbaldehyde
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4431AC
- Product name
- 5-Chloropyrazine-2-carbaldehyde
- Packaging
- 100mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FC162362
- Product name
- 5-Chloropyrazine-2-carboxaldehyde
- Packaging
- 100mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 4431AC
- Product name
- 5-Chloropyrazine-2-carbaldehyde
- Packaging
- 250mg
- Price
- $151
- Updated
- 2021/12/16
- Product number
- FC162362
- Product name
- 5-Chloropyrazine-2-carboxaldehyde
- Packaging
- 250mg
- Price
- $225
- Updated
- 2021/12/16
5-CHLOROPYRAZINE-2-CARBALDEHYDE Chemical Properties,Usage,Production
Synthesis
33332-25-1
88625-24-5
Diisobutylaluminum hydride (1.0 M toluene solution, 6.4 mL, 6.40 mmol) was added slowly and dropwise to a cooled solution of methyl 5-chloropyrazine-2-carboxylate (690 mg, 4.00 mmol) in tetrahydrofuran (THF, 13.6 mL) at -55 °C. The reaction mixture was stirred continuously at this temperature for 1 hour. Subsequently, the reaction was quenched by addition of saturated aqueous ammonium chloride solution (25 mL) and ethyl acetate (EtOAc, 25 mL). If an emulsion was formed, an aqueous 2N hydrochloric acid solution (5 mL) was added to clarify. The organic and aqueous layers were separated and the aqueous layer was then extracted with ethyl acetate. The combined organic layers were washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue was purified by fast silica gel column chromatography with an elution gradient of 0 to 50% ethyl acetate in heptane solution. The product grades were collected and evaporated to dryness under reduced pressure to give 5-chloropyrazine-2-carbaldehyde (385 mg, 68% yield) as a beige solid.1H NMR (500 MHz, CDCl3, 27 °C) δ 8.75 (1H, d), 8.96 (1H, d), 10.15 (1H, d).
References
[1] Patent: WO2018/19793, 2018, A1. Location in patent: Page/Page column 147; 148
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 13, p. 5344 - 5354
[3] Patent: WO2012/81736, 2012, A1. Location in patent: Page/Page column 91-92
[4] Patent: WO2018/93569, 2018, A1
5-CHLOROPYRAZINE-2-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-CHLOROPYRAZINE-2-CARBALDEHYDE manufacturers
- Product
- 5-CHLOROPYRAZINE-2-CARBALDEHYDE 88625-24-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-02