3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester
- Product Name
- 3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester
- CAS No.
- 35286-58-9
- Chemical Name
- 3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester
- Synonyms
- Gouguside 7;Kudinoside H;Zigu-glucoside I;Ziyu-glycoside Ⅰ;Ziyuglycoside I-RM;Ulmus pumila saponin I;3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester;Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, β-D-glucopyranosyl ester, (3β)-;3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester(Kudinoside H:Ziyuglycoside I);[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
- CBNumber
- CB52462159
- Molecular Formula
- C41H66O13
- Formula Weight
- 766.95
- MOL File
- 35286-58-9.mol
3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester Property
- Melting point:
- 198-202 ºC
- Boiling point:
- 841.9±65.0 °C(Predicted)
- Density
- 1.35
- storage temp.
- -20°C, protect from light
- solubility
- Soluble in acetonitrile and methanol;
- form
- powder
- pka
- 12.52±0.70(Predicted)
- color
- White
- Water Solubility
- insoluble in water
N-Bromosuccinimide Price
- Product number
- PHL84269
- Product name
- Ziyuglycoside I
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $435
- Updated
- 2023/06/20
- Product number
- MZ44395
- Product name
- Ziyuglycoside I
- Packaging
- 50mg
- Price
- $470
- Updated
- 2021/12/16
- Product number
- orb573030
- Product name
- 3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester
- Purity
- >98%,Standard References Grade
- Packaging
- 1g
- Price
- $3432.3
- Updated
- 2021/12/16
- Product number
- 107509
- Product name
- ZiyuglycosideI
- Packaging
- 10mg
- Price
- $556
- Updated
- 2021/12/16
- Product number
- CS-0008893
- Product name
- ZiyuglycosideI
- Purity
- 98.51%
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester Chemical Properties,Usage,Production
Chemical Properties
White crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Burnet.
Uses
Used for content determination/identification/pharmacological experiments, etc.
Biological Activity
Ziyuglycoside I, isolated from the roots of S. officinalis, has anti-wrinkle activity and increases collagen type I expression. It can be used as an active ingredient in cosmetics and induces p53-mediated cell cycle arrest and apoptosis (apoptosis), which can be used in the study of triple-negative breast cancer.
Physiological effects
Ziyuglycoside I has the functions of vasoconstriction, hemostasis and antifungal.
in vitro
Ziyuglycoside I (5-160 μM; 24 hours) reveals a marked anti-proliferation activity with an IC 50 value of 13.96 μM in MDA-MB-231 cells. Ziyuglycoside I ( 5-20 μM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 μM. Ziyuglycoside I (5-20 μM; 24 hours) induces the cleavage of caspas- 8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression.
Cell Viability Assay
Cell Line: | MDA-MB-231 cells < /td> |
Concentration: | 5 μM, 10 μM, 20 μM, 40 μM, 80 μM, and 160 μM |
Incubation Time: | 24 hours |
Result: | Showed cytotoxicity on MDA-MB-231 cells. |
Cell Cycle Analysis
Cell Line: | MDA-MB-231 cells |
Concentration: | 5 μM, 10 μM, and 20 μM |
Incubation Time: | 24 hours |
Result: | Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells |
Western Blot Analysis
Cell Line: | MDA-MB-231 cells |
Concentration: | 5 μM, 10 μM, and 20 μM |
Incubation Time: | 24 hours |
Result: | Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways. |
3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester manufacturers
- Product
- ziyu-glycoside I; 3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester 35286-58-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 60%-98% HPLC
- Supply Ability
- 1000KG
- Release date
- 2022-09-16
- Product
- Ziyuglycoside I 35286-58-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-16
- Product
- Ziyuglycoside I 35286-58-9
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-11-20