2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile

Product Name: 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile
CAS No.: 763114-25-6
Chemical Name: 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile
Synonyms: (Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)Methyl)benzonitrile;2-Fluoro-5-(3-oxo-3H-isobenzofuran-1-ylidenemethyl)-benzonitrile;2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)Methyl)benzonitrile;2-fluoro-5-[(Z)-(3-oxo-2-benzofuran-1-ylidene)methyl]benzonitrile;Olaparib Impurity 76;2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)meth;2-fluoro-5-[(Z)-(3-oxo-2-benzofuran-1-ylidene)methyl]benzoni;2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]benzoni...;2-Fluoro-5- (3-oxo-1 (3H) - isobenzofuran) methyl] benzonitrile;2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile
CBNumber: CB52506451
Molecular Formula: C16H8FNO2
Formula Weight: 265.24
MOL File: 763114-25-6.mol

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2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile Property

Boiling point:: 430.1±45.0 °C(Predicted)
Density: 1.38
storage temp.: Sealed in dry,Room Temperature
solubility: Dichloromethane, Tetrahydrofuran
form: Solid
color: White
InChI: InChI=1S/C16H8FNO2/c17-14-6-5-10(7-11(14)9-18)8-15-12-3-1-2-4-13(12)16(19)20-15/h1-8H
InChIKey: MMPHWTMMVPBHRZ-UHFFFAOYSA-N
SMILES: C(#N)C1=CC(C=C2C3=C(C=CC=C3)C(=O)O2)=CC=C1F

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F595100
Product name: 2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile
Packaging: 2.5g
Price: $1320
Updated: 2021/12/16

Apolloscientific

Product number: PC51400
Product name: 2-Fluoro-5-(3-oxo-3H-isobenzofuran-1-ylidenemethyl)-benzonitrile
Purity: 97%
Packaging: 1g
Price: $54
Updated: 2021/12/16

AK Scientific

Product number: 1871AC
Product name: 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile
Packaging: 1g
Price: $77
Updated: 2021/12/16

ChemScene

Product number: CS-M0105
Product name: 2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile
Packaging: 10g
Price: $92
Updated: 2021/12/16

Apolloscientific

Product number: PC51400
Product name: 2-Fluoro-5-(3-oxo-3H-isobenzofuran-1-ylidenemethyl)-benzonitrile
Purity: 97%
Packaging: 5g
Price: $120
Updated: 2021/12/16

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2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile is intermediate in the preparation of poly (ADP-ribose) polymerase (PARP) inhibitors. Olaparib intermediate.

Synthesis

(3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonic acid (5.00 g, 0.021 mol) in tetrahydrofuran (30 mL) was added to a 150 mL round-bottom flask. To this solution, triethylamine(5.6 mL, 0.042 mol) was added. 2-Fluoro-5-formyl benzonitrile( 3.08 g, 0.021 mol) was dissolved in tetrahydrofuran into another round-bottom flask, followed by adding triethylamine (2.9 mL, 0.021 mol) and stirring evenly. Then the reaction fluids in the two flasks were mixed and reacted at room temperature for 12 h. The product was concentrated under reduced pressure and 50 mL of water was added. The suspension was stirred for 30 min until the solids were not precipitated. Finally, filtration was performed, and the filter cake was collected and dried to obtain 2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile(5.41 g, 97%).

2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile Suppliers

Canada 1 China 209 Germany 1 India 5 United Kingdom 1 United States 6 Global 223

Synchem OHG

Tel: +49 5662 408730
Fax: +49 5662 4087320
Email: info@synchem.de
Country: Germany
ProdList: 4705
Advantage: 70

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View Lastest Price from 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile manufacturers

Nanjing Fred Technology Co., Ltd

Product: 2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile 763114-25-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-27

Henan Fengda Chemical Co., Ltd

Product: 2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile 763114-25-6
Price: US $5.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-16

Changzhou Rokechem Technology Co., Ltd.

Product: 2-Fluoro-5-[(3-oxo-1(3H)- isobenzofuranylidene)methyl]-benzonitrile 763114-25-6
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99%，USP/CP/EP
Supply Ability: 1-10000kgs
Release date: 2023-06-08

763114-25-6, 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrileRelated Search:

2-FLUORO-5-METHYLPYRIDINE-3-BORONIC ACID PINACOL ESTER 3-Pyridinemethanamine,6-fluoro-(9CI) Pyridine, 2-fluoro-5-methoxy- (9CI) 2-Fluoro-5-iodobenzonitrile 5-BROMO-2-FLUORONICOTINIC ACID 2-Fluoro-5-iodonitrobenzene 2-Fluoro-5-Iodoaniline 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoyl)piperazine-1-carboxylate 1-(CYCLOPROPANECARBONYL)PIPERAZINE 97 3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride Olaparib Ethanol 1-[2-[4-Hydroxy-3-(2-hydroxyethyl)phenyl]ethyl]-α,α-diphenyl- Dafina new intermediate Obeticholic acid related substance A

2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile

(Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)Methyl)benzonitrile

2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)Methyl)benzonitrile

2-Fluoro-5-(3-oxo-3H-isobenzofuran-1-ylidenemethyl)-benzonitrile

2-fluoro-5-(3-oxo-1,3-dihydroisobenzofuranylidene methyl)benzonitrile

(E)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile

2-fluoro-5-[(Z)-(3-oxo-2-benzofuran-1-ylidene)methyl]benzonitrile

Benzonitrile, 2-fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-

2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)meth

2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]benzoni...

2-fluoro-5-[(3-oxo-1,3-dihydro-2-benzofuran-1-ylidene)methyl]benzonitrile

C16H8FNO2 2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile 763114-25-6

Olaparib Impurity 76

2- Fluoro-5-[(3-oxo-1(3H)-isobenzo-furanylidene)-methyI]I- benzonitrile

2-Fluoro-5- (3-oxo-1 (3H) - isobenzofuran) methyl] benzonitrile

2-fluoro-5-[(Z)-(3-oxo-2-benzofuran-1-ylidene)methyl]benzoni

763114-25-6

C16H8FNO2

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