ON-01910

ChemicalBook > CAS DataBase List > ON-01910

Product Name: ON-01910
CAS No.: 1225497-78-8
Chemical Name: ON-01910
Synonyms: CS-551;Estybon;ON-01910;Rigosertio;ON-01910;ESTYBON;ON-01910 USP/EP/BP;on 1910 sodium salt;ON 01910 sodium salt;brand name: Estybon.;Rigosertib (ON-01910)
CBNumber: CB52514041
Molecular Formula: C21H26NNaO8S
Formula Weight: 475.49
MOL File: 1225497-78-8.mol

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ON-01910 Property

Melting point:: >256oC (dec.)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
color: Pale Yellow to Pale Green

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15553
Product name: ON-01910 (sodium salt)
Purity: ≥98%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 15553
Product name: ON-01910 (sodium salt)
Purity: ≥98%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 15553
Product name: ON-01910 (sodium salt)
Purity: ≥98%
Packaging: 10mg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 15553
Product name: ON-01910 (sodium salt)
Purity: ≥98%
Packaging: 25mg
Price: $330
Updated: 2024/03/01

TRC

Product number: O657000
Product name: ON-01910SodiumSalt
Packaging: 25mg
Price: $250
Updated: 2021/12/16

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ON-01910 Chemical Properties,Usage,Production

Uses

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of Polo-like kinase 1 (PLK1).

Definition

ChEBI: Rigosertib sodium is the sodium salt of rigosertib. It is an anti-cancer agent which has been granted Orphan Drug Designation by the FDA for use in patients with myelodysplastic syndromes (MDS). It has a role as a microtubule-destabilising agent, an antineoplastic agent, an EC 2.7.11.21 (polo kinase) inhibitor and an apoptosis inducer. It contains a rigosertib(1-).

Biological Activity

rigosertib (on-01910,estybon) is a potent, specific plk1 inhibitor with ic50 value of 9nm. rigosertib strongly inhibited the proliferation of cancer cell lines, with observed ic50 values in the nanomolar range for both hela (115 nm) and c33a (45 nm) cells. in contrast, rigosertib had a minimal effect on normal cell lines, bj and ect1/e6e7 (ic50 > 0.1 mm) [1]hela and c33a cells demonstrated a complete (>95%) g2/m arrest at concentrations of rigosertib >0.5 μm, whereas atrigosertib has been reported to be a more potent radiosensitizer than cisplatin in vivo [1].

References

[1] agoni l1, basu i2, gupta s3, alfieri a2, gambino a4, goldberg gl5, reddy ep6, guha c7.rigosertib is a more effective radiosensitizer than cisplatin in concurrent chemoradiation treatment of cervical carcinoma, in vitro and in vivo. int j radiat oncol biol phys. 2014 apr 1;88(5):1180-7.

ON-01910 Preparation Products And Raw materials

Raw materials

Preparation Products

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ON-01910 Suppliers

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1225497-78-8, ON-01910Related Search:

2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol N-ACETYLLACTOSAMINE N,N'-Ethylenebis(stearamide) Deionized water (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride xav-939 U0126-EtOH SB 431542 MG-132 BI 2536 Volasertib (BI 6727)

ON-01910

Estybon

N-[2-Methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine sodium salt

ON 01910 sodium salt

ON-01910;ESTYBON

Rigosertib (ON-01910)

N-[2-methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-glycine,sodium salt (1:1)

N-[2-Methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine sodium salt Rigosertib (ON-01910)

sodium 2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetate|||

Sodium (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetate

Rigosertib Sodium(Random Configuration)

Rigosertib, ON 01910 sodium salt

brand name: Estybon.

ON01910; ON 01910; ON-01910; RIGOSERTIB SODIUM; BRAND NAME: ESTYBON.

Rigosertio

Rigosertib sodium salt

ON-01910; ON01910; ON 01910

ON-01910 (rigosertib)

CS-551

on 1910 sodium salt

2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)vinylsulfonylmethyl]anilino]acetic acid

ON-01910 USP/EP/BP

Sodium (2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)glycinate

Rigosertib sodium (ON-01910)

(E/Z)-Rigosertib sodium

(E/Z)-Rigosertib sodium, 10 mM in DMSO

1225497-78-8

C21H24NO8SNa

Inhibitors

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