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ON-01910

Product Name
ON-01910
CAS No.
1225497-78-8
Chemical Name
ON-01910
Synonyms
CS-551;Estybon;ON-01910;Rigosertio;ON-01910;ESTYBON;ON-01910 USP/EP/BP;on 1910 sodium salt;ON 01910 sodium salt;brand name: Estybon.;Rigosertib (ON-01910)
CBNumber
CB52514041
Molecular Formula
C21H26NNaO8S
Formula Weight
475.49
MOL File
1225497-78-8.mol
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ON-01910 Property

Melting point:
>256oC (dec.)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Methanol (Slightly), Water (Slightly)
form 
Solid
color 
Pale Yellow to Pale Green
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15553
Product name
ON-01910 (sodium salt)
Purity
≥98%
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
15553
Product name
ON-01910 (sodium salt)
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
15553
Product name
ON-01910 (sodium salt)
Purity
≥98%
Packaging
10mg
Price
$150
Updated
2024/03/01
Cayman Chemical
Product number
15553
Product name
ON-01910 (sodium salt)
Purity
≥98%
Packaging
25mg
Price
$330
Updated
2024/03/01
TRC
Product number
O657000
Product name
ON-01910SodiumSalt
Packaging
25mg
Price
$250
Updated
2021/12/16
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ON-01910 Chemical Properties,Usage,Production

Uses

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of Polo-like kinase 1 (PLK1).

Definition

ChEBI: Rigosertib sodium is the sodium salt of rigosertib. It is an anti-cancer agent which has been granted Orphan Drug Designation by the FDA for use in patients with myelodysplastic syndromes (MDS). It has a role as a microtubule-destabilising agent, an antineoplastic agent, an EC 2.7.11.21 (polo kinase) inhibitor and an apoptosis inducer. It contains a rigosertib(1-).

Biological Activity

rigosertib (on-01910,estybon) is a potent, specific plk1 inhibitor with ic50 value of 9nm. rigosertib strongly inhibited the proliferation of cancer cell lines, with observed ic50 values in the nanomolar range for both hela (115 nm) and c33a (45 nm) cells. in contrast, rigosertib had a minimal effect on normal cell lines, bj and ect1/e6e7 (ic50 > 0.1 mm) [1]hela and c33a cells demonstrated a complete (>95%) g2/m arrest at concentrations of rigosertib >0.5 μm, whereas atrigosertib has been reported to be a more potent radiosensitizer than cisplatin in vivo [1].

References

[1] agoni l1, basu i2, gupta s3, alfieri a2, gambino a4, goldberg gl5, reddy ep6, guha c7.rigosertib is a more effective radiosensitizer than cisplatin in concurrent chemoradiation treatment of cervical carcinoma, in vitro and in vivo. int j radiat oncol biol phys. 2014 apr 1;88(5):1180-7.

ON-01910 Preparation Products And Raw materials

Raw materials

Preparation Products

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ON-01910 Suppliers

China 76 India 2 United States 18 Global 96
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
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Fax
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Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
A.J Chemicals
Tel
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Fax
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Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

1225497-78-8, ON-01910Related Search:

2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol N-ACETYLLACTOSAMINE N,N'-Ethylenebis(stearamide) Deionized water (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride xav-939 U0126-EtOH SB 431542 MG-132 BI 2536 Volasertib (BI 6727)

  • ON-01910
  • Estybon
  • N-[2-Methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine sodium salt
  • ON 01910 sodium salt
  • ON-01910;ESTYBON
  • Rigosertib (ON-01910)
  • N-[2-methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-glycine,sodium salt (1:1)
  • N-[2-Methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine sodium salt Rigosertib (ON-01910)
  • sodium 2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetate|||
  • Sodium (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetate
  • Rigosertib Sodium(Random Configuration)
  • Rigosertib, ON 01910 sodium salt
  • brand name: Estybon.
  • ON01910; ON 01910; ON-01910; RIGOSERTIB SODIUM; BRAND NAME: ESTYBON.
  • Rigosertio
  • Rigosertib sodium salt
  • ON-01910; ON01910; ON 01910
  • ON-01910 (rigosertib)
  • CS-551
  • on 1910 sodium salt
  • 2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)vinylsulfonylmethyl]anilino]acetic acid
  • ON-01910 USP/EP/BP
  • Sodium (2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)glycinate
  • Rigosertib sodium (ON-01910)
  • (E/Z)-Rigosertib sodium
  • 1225497-78-8
  • C21H24NO8SNa
  • Inhibitors
  • API