ChemicalBook > CAS DataBase List > 2-Thiobarbituric acid

2-Thiobarbituric acid

Product Name
2-Thiobarbituric acid
CAS No.
504-17-6
Chemical Name
2-Thiobarbituric acid
Synonyms
TBA;THIOBARBITURIC ACID;2-Thioxodihydropyrimidine-4,6(1H,5H)-dione;2-sulfanylpyriMidine-4,6-diol;4,6-DIHYDROXY-2-MERCAPTOPYRIMIDINE;bathyran;austranal;usafek-660;2-Mercapto-4;Thiobarbituric
CBNumber
CB5251676
Molecular Formula
C4H4N2O2S
Formula Weight
144.15
MOL File
504-17-6.mol
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2-Thiobarbituric acid Property

Melting point:
245 °C (dec.)(lit.)
Density 
1.451 (estimate)
refractive index 
1.7690 (estimate)
storage temp. 
Inert atmosphere,2-8°C
solubility 
50g/l slightly soluble
pka
3.96±0.20(Predicted)
form 
Liquid
color 
Clear colorless
PH
1.7-1.9 (10g/l, H2O, 20℃)
Water Solubility 
<6 g/L (20 ºC)
BRN 
120663
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
RVBUGGBMJDPOST-UHFFFAOYSA-N
CAS DataBase Reference
504-17-6(CAS DataBase Reference)
NIST Chemistry Reference
4,6(1H,5h)-pyrimidinedione, dihydro-2-thioxo-(504-17-6)
EPA Substance Registry System
4,6(1H,5H)-Pyrimidinedione, dihydro-2-thioxo- (504-17-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-37/39-26
RIDADR 
UN 3335
WGK Germany 
2
RTECS 
CQ7700000
F 
13-23
TSCA 
Yes
HS Code 
29335995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T5500
Product name
2-Thiobarbituric acid
Purity
≥98%
Packaging
25g
Price
$51.4
Updated
2024/03/01
Sigma-Aldrich
Product number
T5500
Product name
2-Thiobarbituric acid
Purity
≥98%
Packaging
100g
Price
$146
Updated
2024/03/01
Cayman Chemical
Product number
27367
Product name
2-Thiobarbituric Acid
Packaging
50g
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
27367
Product name
2-Thiobarbituric Acid
Packaging
250g
Price
$283
Updated
2024/03/01
Sigma-Aldrich
Product number
T5500
Product name
2-Thiobarbituric acid
Purity
≥98%
Packaging
250g
Price
$336
Updated
2024/03/01
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2-Thiobarbituric acid Chemical Properties,Usage,Production

Chemical Properties

Off-White to Yellow Powder. soluble in hot water, alcohol, ether, alkali and sodium carbonate solution, slightly soluble in water.

Uses

2-Thiobarbituric acid has been used to measure malondialdehyde (MDA) in lipid peroxidation assay.

Uses

4,6-Dihydroxy-2-mercaptopyrimidine can be used to quantitate lipopolysaccharides, carrageenan, and sialic acids, and to detect lipid hydroperoxides and lipid oxidation.

Preparation

2-thiobarbituric acid was synthesized by the reaction of diethyl malonate with thiourea. Dissolve thiourea in methanol, add sodium methoxide and diethyl malonate, heat under reflux for 4-5h, then distill under reduced pressure to recover methanol to the end, and add hydrochloric acid to acidify to pH 1-2 after cooling. After standing overnight, thiobarbituric acid crystals were precipitated, filtered, and recrystallized with water to obtain the pure product.

Definition

ChEBI: 2-thiobarbituric acid is a barbiturate, the structure of which is that of barbituric acid in which the oxygen at C-2 is replaced by sulfur. It has a role as a reagent and an allergen.

General Description

2-Thiobarbituric acid is a molecule made up of heteroatoms: nitrogen, sulphur and oxygen.

Biochem/physiol Actions

2-Thiobarbituric acid (TBA) is useful to quantitate lipopolysaccharides, carrageenan, and sialic acids. It is also used to detect lipid hydroperoxides and lipid oxidation. It has applications in the field of medicine and biochemistry. TBA may possess the ability to prevent metal corrosion.

Purification Methods

Crystallise it from water. [Beilstein 24 H 476, 24 I 414, 24 II 275, 24 III/IV 1884.]

2-Thiobarbituric acid Preparation Products And Raw materials

Raw materials

Sodium Methoxide Thiourea

Preparation Products

2-(methylthio)pyrimidine-4,6-diol
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View Lastest Price from 2-Thiobarbituric acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Thiobarbituric acid 504-17-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-06
Hebei Weibang Biotechnology Co., Ltd
Product
2-Thiobarbituric acid 504-17-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Hebei Yanxi Chemical Co., Ltd.
Product
2-Thiobarbituric acid 504-17-6
Price
US $70.00-10.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-15

504-17-6, 2-Thiobarbituric acidRelated Search:

Solvent Red 43 Calcium thioglycolate Sodium thioglycolate 3-Mercaptopropionic acid Ethyl 2-(Chlorosulfonyl)acetate Folic acid POTASSIUM THIOGLYCOLATE 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL Barbituric acid 4,6-Dihydroxypyrimidine 2-Ethylhexyl mercaptoacetate Mercaptoacetic acid Succimer Ascoric Acid 2-Mercaptoethanol 1,3-DIETHYL-2-THIOBARBITURIC ACID 4,6-DIHYDROXY-2-MERCAPTOPYRIMIDINE SODIUM SALT Pyrimidine

  • 6(1H,5H)-Pyrimidinedione,dihydro-2-thioxo-4
  • austranal
  • bathyran
  • Dihydro-2-thioxo-4,6-(1H,5H)-pyrimidinedione
  • dihydro-2-thioxo-4,6(1h,5h)-pyrimidinedione
  • Mealonylthiourea
  • Thiobarbituicacid
  • Thiobarbituric
  • 2-THIOBARBITURICACID,REAGENT
  • 2-MERCAPTO-4,6-DIHYDROXYPYRIMIDINE (2-THIOBARBITURIC ACID)
  • ThiobarbituricAcidGr
  • 1-ThioglycerolGr90%
  • 2-ThiobarbituricAcid98%
  • 4,6(1H,5H)-Pyrimidinedione, dihydro-2-thioxo- (9CI)
  • 4,6(1H,5H)-PYRIMIDINEDIONE, DIHYDRO-2-THIOXO-
  • 4,6-DIHYDROXY-2-MERCAPTOPYRIMIDINE
  • 4,6-DIHYDROXY-2-THIOPYRIMIDINE
  • 4,6-DIHYDROXYPYRIMIDINE-2-THIOL
  • 2-thiobarbituric acid minimum 98%
  • Thiobarbituric Acid, 2-
  • 4,6-Dihydroxy-2-mercaptopyrimidine, 4,6-Dihydroxypyrimidine-2-thiol, TBA
  • 2-Thio-4,6-dioxypyrimidine
  • 2-Thioxo-6-hydroxy-1,2,3,4-tetrahydropyrimidine-4-one
  • 6-Hydroxy-2-thioxo-1,2-dihydropyrimidin-4(3H)-one
  • 2,3-Dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
  • 4,6-Dihydroxy-2-mercaptopyrimidine,98%
  • 3,4-Dihydroxy-2-mercaptopyrimidine
  • 2-Thioxo-dihydro-pyrimidine-4,6-dione
  • usafek-660
  • 4,6-Dihydroxypyrimidine-2-thiol ( 2-Thiobarbitursure)
  • 2-THIOBARBITURIC ACIDANALYTICAL GRADE
  • MALONYLTHIOUREA
  • LABOTEST-BB LT00440785
  • AURORA KA-3842
  • 2-MERCAPTO-4,6-DIHYDROXY-PYRIMIDINE
  • 2-THIOBARBITURIC ACID
  • 2-Mercapto-4
  • 2-Thiobarbituric Acid [for BiocheMical Research]
  • 2-sulfanylpyriMidine-4,6-diol
  • 4,6-Dihydroxy-2-MercaptopyriMidine, 98% 100GR
  • 4,6-Dihydroxy-2-MercaptopyriMidine, 98% 5GR
  • 4.6-Dihydroxy-2-mercaptopyrimidine 1g [504-17-6]
  • 2-Thiobarbituric acid p.a.
  • 4,6-Dihydroxy-2-merc
  • 4,6-DihydroxypyriMidine-2-thiol (2-Thiobarbitursre)
  • 2-THIOBARBITURIC ACID REAGENT FOR SORBIC
  • HexahydropyriMidine-4,6-dione-2-thione
  • Thiobarbituric aci
  • thiobarbituric acid (TBA)
  • 2 - Mercapto - 4, 6-2 hydroxy pyriMidine
  • 2-Thiobarbituric acid Vetec(TM) reagent grade, >=98%
  • 2-Thiobarbituric acid(TBA)
  • 2-Mercaptopyrimidine-4,6-dione
  • 2-Thioxodihydropyrimidine-4,6(1H,5H)-dione
  • TIMTEC-BB SBB004132
  • THIOBARBITURIC ACID
  • 2-mercaptobarbituricacid
  • 2-thio-barbituricaci