2-Thiobarbituric acid

Product Name: 2-Thiobarbituric acid
CAS No.: 504-17-6
Chemical Name: 2-Thiobarbituric acid
Synonyms: TBA;THIOBARBITURIC ACID;2-Thioxodihydropyrimidine-4,6(1H,5H)-dione;2-sulfanylpyriMidine-4,6-diol;4,6-DIHYDROXY-2-MERCAPTOPYRIMIDINE;bathyran;austranal;usafek-660;2-Mercapto-4;Thiobarbituric
CBNumber: CB5251676
Molecular Formula: C4H4N2O2S
Formula Weight: 144.15
MOL File: 504-17-6.mol

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2-Thiobarbituric acid Property

Melting point:: 245 °C (dec.)(lit.)
Density: 1.451 (estimate)
refractive index: 1.7690 (estimate)
storage temp.: Inert atmosphere,2-8°C
solubility: 50g/l slightly soluble
pka: 3.96±0.20(Predicted)
form: Liquid
color: Clear colorless
PH: 1.7-1.9 (10g/l, H2O, 20℃)
Water Solubility: <6 g/L (20 ºC)
BRN: 120663
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: RVBUGGBMJDPOST-UHFFFAOYSA-N
CAS DataBase Reference: 504-17-6(CAS DataBase Reference)
NIST Chemistry Reference: 4,6(1H,5h)-pyrimidinedione, dihydro-2-thioxo-(504-17-6)
EPA Substance Registry System: 4,6(1H,5H)-Pyrimidinedione, dihydro-2-thioxo- (504-17-6)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-37/39-26
RIDADR: UN 3335
WGK Germany: 2
RTECS: CQ7700000
F: 13-23
TSCA: Yes
HS Code: 29335995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T5500
Product name: 2-Thiobarbituric acid
Purity: ≥98%
Packaging: 25g
Price: $51.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: T5500
Product name: 2-Thiobarbituric acid
Purity: ≥98%
Packaging: 100g
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 27367
Product name: 2-Thiobarbituric Acid
Packaging: 50g
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 27367
Product name: 2-Thiobarbituric Acid
Packaging: 250g
Price: $283
Updated: 2024/03/01

Sigma-Aldrich

Product number: T5500
Product name: 2-Thiobarbituric acid
Purity: ≥98%
Packaging: 250g
Price: $336
Updated: 2024/03/01

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2-Thiobarbituric acid Chemical Properties,Usage,Production

Chemical Properties

Off-White to Yellow Powder. soluble in hot water, alcohol, ether, alkali and sodium carbonate solution, slightly soluble in water.

Uses

2-Thiobarbituric acid has been used to measure malondialdehyde (MDA) in lipid peroxidation assay.

Uses

4,6-Dihydroxy-2-mercaptopyrimidine can be used to quantitate lipopolysaccharides, carrageenan, and sialic acids, and to detect lipid hydroperoxides and lipid oxidation.

Preparation

2-thiobarbituric acid was synthesized by the reaction of diethyl malonate with thiourea. Dissolve thiourea in methanol, add sodium methoxide and diethyl malonate, heat under reflux for 4-5h, then distill under reduced pressure to recover methanol to the end, and add hydrochloric acid to acidify to pH 1-2 after cooling. After standing overnight, thiobarbituric acid crystals were precipitated, filtered, and recrystallized with water to obtain the pure product.

Definition

ChEBI: 2-thiobarbituric acid is a barbiturate, the structure of which is that of barbituric acid in which the oxygen at C-2 is replaced by sulfur. It has a role as a reagent and an allergen.

General Description

2-Thiobarbituric acid is a molecule made up of heteroatoms: nitrogen, sulphur and oxygen.

Biochem/physiol Actions

2-Thiobarbituric acid (TBA) is useful to quantitate lipopolysaccharides, carrageenan, and sialic acids. It is also used to detect lipid hydroperoxides and lipid oxidation. It has applications in the field of medicine and biochemistry. TBA may possess the ability to prevent metal corrosion.

Purification Methods

Crystallise it from water. [Beilstein 24 H 476, 24 I 414, 24 II 275, 24 III/IV 1884.]

2-Thiobarbituric acid Preparation Products And Raw materials

Raw materials

Sodium Methoxide Thiourea

Preparation Products

2-(methylthio)pyrimidine-4,6-diol

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2-Thiobarbituric acid Suppliers

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View Lastest Price from 2-Thiobarbituric acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Thiobarbituric acid 504-17-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-06

Hebei Weibang Biotechnology Co., Ltd

Product: 2-Thiobarbituric acid 504-17-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Hebei Yanxi Chemical Co., Ltd.

Product: 2-Thiobarbituric acid 504-17-6
Price: US $70.00-10.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-15

504-17-6, 2-Thiobarbituric acidRelated Search:

Solvent Red 43 Calcium thioglycolate Sodium thioglycolate 3-Mercaptopropionic acid Ethyl 2-(Chlorosulfonyl)acetate Folic acid POTASSIUM THIOGLYCOLATE 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL Barbituric acid 4,6-Dihydroxypyrimidine 2-Ethylhexyl mercaptoacetate Mercaptoacetic acid Succimer Ascoric Acid 2-Mercaptoethanol 1,3-DIETHYL-2-THIOBARBITURIC ACID 4,6-DIHYDROXY-2-MERCAPTOPYRIMIDINE SODIUM SALT Pyrimidine

6(1H,5H)-Pyrimidinedione,dihydro-2-thioxo-4

austranal

bathyran

Dihydro-2-thioxo-4,6-(1H,5H)-pyrimidinedione

dihydro-2-thioxo-4,6(1h,5h)-pyrimidinedione

Mealonylthiourea

Thiobarbituicacid

Thiobarbituric

2-THIOBARBITURICACID,REAGENT

2-MERCAPTO-4,6-DIHYDROXYPYRIMIDINE (2-THIOBARBITURIC ACID)

ThiobarbituricAcidGr

1-ThioglycerolGr90%

2-ThiobarbituricAcid98%

4,6(1H,5H)-Pyrimidinedione, dihydro-2-thioxo- (9CI)

4,6(1H,5H)-PYRIMIDINEDIONE, DIHYDRO-2-THIOXO-

4,6-DIHYDROXY-2-MERCAPTOPYRIMIDINE

4,6-DIHYDROXY-2-THIOPYRIMIDINE

4,6-DIHYDROXYPYRIMIDINE-2-THIOL

2-thiobarbituric acid minimum 98%

Thiobarbituric Acid, 2-

4,6-Dihydroxy-2-mercaptopyrimidine, 4,6-Dihydroxypyrimidine-2-thiol, TBA

2-Thio-4,6-dioxypyrimidine

2-Thioxo-6-hydroxy-1,2,3,4-tetrahydropyrimidine-4-one

6-Hydroxy-2-thioxo-1,2-dihydropyrimidin-4(3H)-one

2,3-Dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione

4,6-Dihydroxy-2-mercaptopyrimidine,98%

3,4-Dihydroxy-2-mercaptopyrimidine

2-Thioxo-dihydro-pyrimidine-4,6-dione

usafek-660

4,6-Dihydroxypyrimidine-2-thiol ( 2-Thiobarbitursure)

2-THIOBARBITURIC ACIDANALYTICAL GRADE

MALONYLTHIOUREA

LABOTEST-BB LT00440785

AURORA KA-3842

2-MERCAPTO-4,6-DIHYDROXY-PYRIMIDINE

2-THIOBARBITURIC ACID

2-Mercapto-4

2-Thiobarbituric Acid [for BiocheMical Research]

2-sulfanylpyriMidine-4,6-diol

4,6-Dihydroxy-2-MercaptopyriMidine, 98% 100GR

4,6-Dihydroxy-2-MercaptopyriMidine, 98% 5GR

4.6-Dihydroxy-2-mercaptopyrimidine 1g [504-17-6]

2-Thiobarbituric acid p.a.

4,6-Dihydroxy-2-merc

4,6-DihydroxypyriMidine-2-thiol (2-Thiobarbitursre)

2-THIOBARBITURIC ACID REAGENT FOR SORBIC

HexahydropyriMidine-4,6-dione-2-thione

Thiobarbituric aci

thiobarbituric acid (TBA)

2 - Mercapto - 4, 6-2 hydroxy pyriMidine

2-Thiobarbituric acid Vetec(TM) reagent grade, >=98%

2-Thiobarbituric acid(TBA)

2-Mercaptopyrimidine-4,6-dione

2-Thioxodihydropyrimidine-4,6(1H,5H)-dione

TIMTEC-BB SBB004132

THIOBARBITURIC ACID

2-mercaptobarbituricacid

2-thio-barbituricaci