2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid
- Product Name
- 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid
- CAS No.
- 890842-28-1
- Chemical Name
- 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid
- Synonyms
- CS-1142;GSK 650394;GSK650394 ，S7209;GSK650394 (Free base);SGK inhibitor GS650394;GSK 650394, 10 mM in DMSO;6-O-α-D-Glucopyranosyl-D-glucose;2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid;Benzoic acid, 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-
- CBNumber
- CB52518968
- Molecular Formula
- C25H22N2O2
- Formula Weight
- 382.45
- MOL File
- 890842-28-1.mol
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid Property
- storage temp.
- room temp
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML0773
- Product name
- GSK-650394
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $154
- Updated
- 2025/07/31
- Product number
- SML0773
- Product name
- GSK-650394
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $615
- Updated
- 2025/07/31
- Product number
- 17001
- Product name
- GSK650394
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 17001
- Product name
- GSK650394
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $198
- Updated
- 2024/03/01
- Product number
- 17001
- Product name
- GSK650394
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $467
- Updated
- 2024/03/01
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid Chemical Properties,Usage,Production
Uses
GSK-650394 has been used as a serum and glucocorticoid-activated kinase (SGK1) inhibitor.
Definition
ChEBI: 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid is a phenylpyridine.
Biochem/physiol Actions
GSK-650394 has an IC50 value of 62?nM for serum and glucocorticoid-activated kinase-1 (SGK1) and 103?nM for SGK2. It has an ability to stop viral replication at concentrations that are nontoxic to cells.
in vivo
GSK650394 (1, 10, and 30 μM, 10 μL/rat, intrathecally) dose-dependently prevents CFA-induced pain behavior and the associates SGK1 phosphorylation, GluR1 trafficking, and protein-protein interactions at 1 day after CFA administration[3]. GSK650394 at concentrations of 10, 30, and 100 nM (10 μL), but not vehicle solution (SNL 3D+Veh and SNL 7D+Veh, respectively), dose-dependently increases the withdrawal latency of the ipsilateral hindpaw at 1-3 and 1-5 h after injection at days 3 and 7 postsurgery (SNL 3D+GSK and SNL 7D+GSK, respectively). GSK650394 (from day 0 to 6 postsurgery; 100 nM, 10 μL, i.t.) administration alleviates SNL-induced allodynia at days 3, 5, and 7 postsurgery in SNL animals[4].
IC 50
SGK1
storage
Store at RT
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid Suppliers
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- Country
- The Netherlands
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